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Efficacy and safety of biologic agents and tofacitinib in moderate-to-severe ulcerative colitis: A systematic overview of meta-analyses.

Author: BonovasStefanos, DaneseSilvio, EvripidouDespo, NikolopoulosGeorgios K, PantavouKaterina, Peyrin-BirouletLaurent, PiovaniDaniele, YiallourouAnneza I

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Biologics and tofacitinib are efficacious and safe for treating ulcerative colitis (UC). All four biologics (adalimumab, golimumab, infliximab, vedolizumab) and tofacitinib were superior to placebo in terms of efficacy. Infliximab may be better than adalimumab and golimumab for inducing clinical response and mucosal healing.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Ulcerative colitis (UC) is an inflammatory disease of the colon and rectum. Treatment options include biologics and tofacitinib. OBJECTIVES: We aim to summarize the evidence on efficacy and safety of biologics and tofacitinib in moderate-to-severe UC. METHODS: PubMed, Embase, Scopus, a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894001/

データ提供：米国国立医学図書館（NLM）

Ulcerative Colitis: Exploring New Frontiers in Treatment

Ulcerative colitis, a chronic inflammatory bowel disease, can be a challenging condition to manage. This study provides a comprehensive overview of the current research on the efficacy and safety of biologics and tofacitinib, two classes of medications used to treat moderate-to-severe ulcerative colitis. Think of these medications as two different types of desert springs, each offering a unique source of relief and healing.

The researchers conducted a systematic overview of meta-analyses, summarizing the evidence from numerous clinical trials. They found that both biologics and tofacitinib were effective in inducing and maintaining clinical response, clinical remission, and mucosal healing. These medications were generally well-tolerated, with few significant adverse events.

Biologics and Tofacitinib: Promising Options for Ulcerative Colitis

This review highlights the effectiveness of biologics and tofacitinib in treating ulcerative colitis. These medications offer patients a much-needed respite from the debilitating symptoms of this condition. Think of these medications as two powerful desert winds, calming the inflammation and bringing a sense of relief to patients.

Living with Ulcerative Colitis: A Journey of Hope

Managing ulcerative colitis is a lifelong journey that often involves a combination of treatments and lifestyle modifications. This review provides valuable information for healthcare providers and patients, offering hope for effective management and a better quality of life.

Dr.Camel's Conclusion

This review offers a comprehensive overview of the current research on the efficacy and safety of biologics and tofacitinib in treating ulcerative colitis. These medications offer patients a much-needed respite from the debilitating symptoms of this condition. This research is like discovering two new desert oases, offering hope and relief for patients seeking effective treatment for ulcerative colitis.

Date :
  1. Date Completed 2020-06-29
  2. Date Revised 2020-06-29
Further Info :

Pubmed ID

31839954

DOI: Digital Object Identifier

PMC6894001

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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