Assessing the Efficacy and Safety of Liposomal Amphotericin B and Miltefosine in Combination for Treatment of Post Kala-Azar Dermal Leishmaniasis.

Author: DixitKeerti Kaumudee, RameshV, SalotraPoonam, SharmaNeha, SinghRuchi

Paper Details 
Original Abstract of the Article :
No satisfactory canonical treatment is available for post-kala-azar dermal leishmaniasis (PKDL), clinical sequela of visceral leishmaniasis. Confined treatment options and substantial increase in relapse rate after miltefosine (MIL) treatment warrant the need to adapt resilient combination therapies...See full text at original site
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引用元:
https://doi.org/10.1093/infdis/jiz486

データ提供:米国国立医学図書館(NLM)

Combating Post Kala-Azar Dermal Leishmaniasis: A New Oasis in the Desert of Leishmaniasis

Post kala-azar dermal leishmaniasis (PKDL) is a neglected tropical disease that can cause significant skin lesions and discomfort. It's like a desert mirage, where the skin becomes disfigured and uncomfortable, leaving individuals feeling isolated and frustrated. This research explores the potential of a combination therapy using liposomal amphotericin B (LAmB) and miltefosine (MIL) for treating PKDL.

The researchers recognized the need for more effective treatment options for PKDL, as existing treatments often have limitations and lead to high relapse rates. They conducted a study to assess the safety and efficacy of combining LAmB and MIL, aiming to improve treatment outcomes.

A New Hope for a Neglected Disease

This research offers a hopeful approach to treating PKDL, highlighting the potential of combining LAmB and MIL to improve treatment outcomes. It's like finding a new oasis in the desert of leishmaniasis, offering potential for better management and improved quality of life for those affected.

A Reminder for Continued Research

It's essential to continue researching and developing effective treatments for PKDL. Like discovering new springs in a desert, research is crucial for finding solutions to this neglected tropical disease and improving the lives of those affected.

Dr.Camel's Conclusion

This research sheds light on the potential of a combination therapy using LAmB and MIL for treating PKDL, offering a new ray of hope in the desert of leishmaniasis. It's a reminder that collaborative efforts and continued research are essential to fight neglected diseases and improve global health.

Date :
  1. Date Completed 2020-09-21
  2. Date Revised 2020-09-21
Further Info :

Pubmed ID

31854451

DOI: Digital Object Identifier

10.1093/infdis/jiz486

Related Literature

SNS
PICO Info
in preparation
Languages

English

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