Effects of amphotericin b liposomal injection: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Major Research Findings

Amphotericin B liposomal injection has been shown to be effective in treating various fungal infections in a number of studies. In particular, studies 18 , 17 , 11 , 10 , 16 have shown it to be effective in treating intraocular infections, especially endophthalmitis caused by Candida and Aspergillus. Study 19 also confirms its effectiveness against cutaneous leishmaniasis. Moreover, study 5 suggests that amphotericin B liposomes may be used to prevent and reverse behavioral abnormalities triggered by chronic stress.

On the other hand, study 15 shows that paromomycin ointment and liquid nitrogen are also effective in treating cutaneous leishmaniasis, in addition to amphotericin B liposomes. Study 3 indicates that surgical treatment is also necessary for treating mucormycosis, in addition to amphotericin B liposomes. Furthermore, study 2 suggests that combination therapy using amphotericin B liposomes with other drugs may be effective in treating cutaneous leishmaniasis.

Benefits and Risks

Benefit Summary

Amphotericin B liposomal injection has been shown to be effective in treating a variety of fungal infections, especially intraocular infections, cutaneous leishmaniasis, and mucormycosis. It has also been shown to have the potential to improve behavioral abnormalities caused by chronic stress. Furthermore, combination therapy with other drugs may be effective.

Risk Summary

Amphotericin B liposomal injection carries risks of kidney toxicity, fever, nausea, vomiting, and other side effects. It can also cause injection site reactions and allergic reactions, such as anaphylaxis. It is important to consider these risks and receive appropriate doses under the guidance of a physician.

Comparison Between Studies

Commonalities

Many studies have shown that amphotericin B liposomal injection is effective in treating a variety of fungal infections. They have also shown that there is a risk of side effects such as kidney toxicity.

Differences

Studies differ in terms of the types of fungi targeted, treatment effectiveness, and frequency of side effects. Therefore, it is important to consider the results of each study holistically.

Consistency and Contradictions of Results

Many studies have confirmed the effectiveness of amphotericin B liposomal injection. However, some studies have shown that it has a high risk of side effects. Therefore, it is important to assess the safety and effectiveness of amphotericin B liposomal injection comprehensively.

Precautions for Real-Life Applications

Amphotericin B liposomal injection should be administered appropriately under the diagnosis and guidance of a physician. It is also important to understand the risks of side effects and consult with your physician if necessary.

Current Research Limitations

Research evaluating the effectiveness and safety of amphotericin B liposomal injection is still insufficient. In particular, there is a lack of research on long-term effects and side effects.

Future Research Directions

Research evaluating the long-term effects and side effects of amphotericin B liposomal injection is needed. Research evaluating the effectiveness and safety of the drug against a variety of fungal infections is also needed.

Conclusion

Amphotericin B liposomal injection has the potential to be effective in treating a variety of fungal infections. However, because it also carries the risk of side effects, it is important to receive appropriate doses under the guidance of a physician. Further research is needed to more fully evaluate the effectiveness and safety of amphotericin B liposomal injection.

Literature analysis of 19 papers
Positive Content
17
Neutral Content
1
Negative Content
1
Article Type
1
0
1
4
18
1.

Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone.

Author: McCreaJacqueline B, MajumdarAnup K, GoldbergMichael R, IwamotoMarian, GarganoCynthia, PanebiancoDeborah L, HesneyMichael, LinesChristopher R, PettyKevin J, DeutschPaul J, MurphyM Gail, GottesdienerKeith M, GoldwaterD Ronald, BlumRobert A

Prevents nausea and vomiting
Drug interaction

This study evaluated the effects of aprepitant on dexamethasone and methylprednisolone, two corticosteroids that are substrates of cytochrome P4503A4. Aprepitant was found to increase the levels of both dexamethasone and methylprednisolone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.

Author: YounisBrima Musa, Mudawi MusaAhmed, MonneratSéverine, Abdelrahim SaeedMohammed, Awad Gasim KhalilEltahir, Elbashir AhmedAnas, Ahmed AliMujahid, NoureldinAli, Muthoni OuattaraGina, NyakayaGodfrey M, TeshomeSamuel, OmolloTruphosa, OchiengMichael, EgondiThaddaeus, MmboneMildred, ChuWan-Yu, DorloThomas P C, ZijlstraEduard E, WasunnaMonique, AlvarJorge, AlvesFabiana

PKDL treatment
Toxicity

The study assessed the safety and efficacy of a combination therapy of miltefosine, paromomycin, and liposomal amphotericin B for the treatment of post-kala-azar dermal leishmaniasis (PKDL) in Sudan. The combination therapy showed promising results in terms of safety and efficacy, offering a potential alternative to existing treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Mucormycosis, Diabetes and COVID-19 Pneumonia: Unleashing the Facts.

Author: ShastriMinal, RavalDarshankumar M, PatelDirgha, PatelAastha B, ChopraAakriti, RathodVaishnavi M, DobariyaRiya, PatelNilay S, PatelNupur H, PatelApurva, GohelDevang M

Mucormycosis treatment
Electrolyte abnormalities
Renal impairment

Diabetes and COVID-19 infection are major contributors to mucormycosis (MM), an aggressive fungal infection. While antifungal treatment and early surgical intervention improve outcomes, uncontrolled diabetes, severe COVID-19 infection, and brain involvement are associated with poor outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Retrobulbar Injection of Amphotericin B in Patients With COVID-19 Associated Orbital Mucormycosis: A Systematic Review.

Author: SharifiAli, AkbariZahra, Shafie'eiMohammad, NasiriNaser, SharifiMeraj, ShafieiMohadeseh, ZandAmin

Globe salvage

This study examines the protocols, outcomes, and side effects of retrobulbar amphotericin B injections for globe salvage in patients with COVID-19-associated rhino-orbito-cerebral mucormycosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Assessing the Efficacy and Safety of Liposomal Amphotericin B and Miltefosine in Combination for Treatment of Post Kala-Azar Dermal Leishmaniasis.

Author: RameshV, DixitKeerti Kaumudee, SharmaNeha, SinghRuchi, SalotraPoonam

Treatment of PKDL

This study assessed the safety and efficacy of a combination therapy using liposomal amphotericin B (LAmB) and miltefosine (MIL) for the treatment of post-kala-azar dermal leishmaniasis (PKDL).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Comparison of the effectiveness of caspofungin and liposomal amphotericin-B for the treatment of C. tropicalis-induced peritonitis in mice.

Author: DemirciMelis, TüngerÖzlem, ÇetinÇiğdem Banu, SenolŞebnem

Decreased fungal growth

Liposomal amphotericin B and caspofungin are effective treatments for Candida tropicalis-induced peritonitis in mice.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Intrahepatic Administration of Liposomal Amphotericin B (Ambisome) for the Management of a Liver Abscess from <i>Candida albicans</i> in a Preterm Infant.

Author: AuritiCinzia, RonchettiMaria Paola, BersaniIliana, GennariFabrizio, PiersigilliFiammetta

Treats hepatic fungal abscesses

This case report describes a preterm neonate who developed an intrahepatic abscess due to parenteral extravasation and subsequent contamination with Candida albicans. Despite maximal pharmacological therapies, surgical drainage followed by direct intralesional administration of liposomal amphotericin B (Ambisome) led to definitive resolution of the abscess. This approach has not been previously described in neonates and proved to be a safe and effective treatment option.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Case of cryptococcal choroiditis in adult with T-cell leukemia/lymphoma.

Author: YamadaWataru, YamadaHiroki, MurataKazuhiro, KosugiHiroshi, AsanoYuko, MochizukiKiyofumi, IshidaKyoko

Intraocular cryptococcosis treatment

A case of a 70-year-old woman with adult T-cell leukemia/lymphoma who developed multifocal choroiditis from disseminated Cryptococcus neoformans is reported. Prompt therapy with intravitreal injection and systemic antifungals led to clinical improvement.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Gastric Mucormycosis in a Liver and Kidney Transplant Recipient: Case Report and Concise Review of Literature.

Author: AlfanoG, FontanaF, FrancescaD, AssiratiG, MagistriP, TarantinoG, BallarinR, RossiG, FranceschiniE, CodeluppiM, GuaraldiG, MussiniC, Di BenedettoF, CappelliG

Maintained organ function
Successful mucormycosis treatment
Gastrointestinal side effects
Graft rejection

A case of gastric mucormycosis in a liver-kidney transplant patient was successfully treated with liposomal amphotericin B and posaconazole.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis.

Author: WijnantGert-Jan, Van BocxlaerKatrien, YardleyVanessa, HarrisAndy, MurdanSudaxshina, CroftSimon L

CL treatment

This study compared the skin pharmacokinetics of liposomal amphotericin B (LAmB) and deoxycholate amphotericin B (DAmB) in murine models of cutaneous leishmaniasis (CL). LAmB showed higher drug levels at the lesion site after both single and multiple doses compared to DAmB. Importantly, there was a clear correlation between the dose level, intralesional AmB concentration, and the reduction in parasite load and lesion size. This confirms the improved efficacy of LAmB over DAmB in experimental CL, which is linked to higher drug accumulation in the lesion.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Clinical Analysis of Diabetic Combined Pulmonary Mucormycosis.

Author: LiYu-Hong, SunPeng, GuoJian-Chao

Early diagnosis
Fatal infection

Diabetic combined pulmonary mucormycosis is a rare but fatal fungal infection disease. Early diagnosis and treatment are essential to improve the prognosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

[CUTANEOUS LEISHMANIASIS IN ISRAEL 2016 - AN UPDATE].

Author: SolomonMichal, SchwartzEli

Treatment for Leishmaniasis
Muco-cutaneous involvement
Severe leishmaniasis

This article provides an overview of leishmaniasis in Israel, including the endemic species, clinical presentation, and treatment options. It discusses the increasing prevalence of the disease and the importance of identifying the exact species for appropriate treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hebrew

16.

Cutaneous mucormycosis as result of insulin administration in an AML patient: Case report and review of the literature.

Author: DelieAnke, VlummensPhilip, CreytensDavid, SteelEva

Mucormycosis treatment
Diabetes
Leukemia

This report describes a case of cutaneous mucormycosis in a patient with several important risk factors, namely underlying acute myeloid leukaemia and poorly controlled secondary diabetes. The patient was successfully treated with surgical debridement and liposomal Amphotericin B (LAmB).

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

A Comparative Treatment Study of Intravitreal Voriconazole and Liposomal Amphotericin B in an Aspergillus fumigatus Endophthalmitis Model.

Author: ZhaoJinsong, ChengYan, SongXiande, WangChenguang, SuGuanfang, LiuZaoxia

Endophthalmitis treatment

Voriconazole and liposomal amphotericin B are effective in treating Aspergillus fumigatus-induced endophthalmitis in guinea pigs. Voriconazole was superior to liposomal Amp-B at similar doses.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Intravitreal liposomal amphotericin B for treatment of endogenous candida endophthalmitis.

Author: BaeJeong Hun, LeeSung Chul

Candida endophthalmitis treatment
Well tolerated
Toxic uveitis

A case series of four patients with endogenous candida endophthalmitis found that intravitreal liposomal amphotericin B (L-AmB) was well tolerated and effective in the treatment of endogenous candida endophthalmitis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

[Successful treatment of cutaneous leishmaniasis with amphotericin B; a case of unresponsive to pentavalent antimony therapy].

Author: YeşilovaYavuz, TuranEnver, SürücüHacer Altın, AksoyMustafa, ÖzbilginAhmet

CL treatment
Local side effects

This study presents a successful treatment with systemic liposomal amphotericin B of a cutaneous leishmaniasis case that developed local side effects related to both systemic and intralesional meglumine antimonate treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Turkish

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