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miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA.

Author: BoutrosPaul C, DownesMichelle, Dura-PerezLara, HaugheyCharles, HoeyChristianne, JainSuneil, JeonJouhyun, LiuStanley K, McCabeNuala, MillsIan G, MurphyRoss, RayJessica

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the role of miR-191 in prostate cancer radiotherapy resistance. The study found that miR-191 promotes resistance and that targeting miR-191 or its target RXRA with retinoids may improve radiotherapy response.
Paper Details　
Original Abstract of the Article :
Radiation therapy is a common treatment for prostate cancer, however recurrence remains a problem. MicroRNA expression is altered in prostate cancer and may promote therapy resistance. Through bioinformatic analyses of TCGA and CPC-GENE patient cohorts, we identified higher miR-191 expression in tum...See full text at original site
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引用元：
https://doi.org/10.1016/j.canlet.2019.12.025

データ提供：米国国立医学図書館（NLM）

miR-191: A Hidden Oasis in the Desert of Prostate Cancer

Prostate cancer is a complex disease that often returns despite treatment. This study explores the role of microRNA-191 (miR-191), a small molecule that regulates gene expression, in promoting radiation resistance in prostate cancer. The researchers investigated the relationship between miR-191 and retinoid X receptor alpha (RXRA), a protein involved in cell growth and development.

The researchers found that higher levels of miR-191 were associated with increased radiation resistance in prostate cancer cells. They discovered that miR-191 targets RXRA, inhibiting its function and contributing to the development of radioresistance. The study also found that treatment with the RXRA agonist 9-cis-retinoic acid could restore radiosensitivity in prostate cancer cells.

The Desert of Prostate Cancer: Finding New Pathways to Treatment

This study unveils a new pathway to understanding radiation resistance in prostate cancer, highlighting the potential of targeting miR-191 and RXRA for improving treatment outcomes. The researchers' findings offer a glimmer of hope in the ongoing search for more effective treatments for this challenging disease.

Dr. Camel's Conclusion

Prostate cancer is a formidable desert, and radiation resistance is a formidable sand dune. This study reveals a new pathway to understanding the mechanisms of radiation resistance, shedding light on the role of miR-191 and RXRA. The findings offer a potential oasis in the desert of prostate cancer, suggesting new avenues for developing more effective treatments.

Date :
  1. Date Completed 2020-10-05
  2. Date Revised 2021-11-22
Further Info :

Pubmed ID

31874245

DOI: Digital Object Identifier

10.1016/j.canlet.2019.12.025

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English

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