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Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.

Author: AbedAbdulkareem, AboelattaMones M, AspromonteSalvatore M, BommareddyPraveen K, BroucekJoseph R, BuddhadevStuti, ChessonC Brent, DenzinLisa K, EstupinianRicardo, FidlerMary Jo, GiuriniEileena F, GoldufskyJosef W, Guevara-AlemanGabriel, GuptaKajal H, GuptaVineet, HerzogNora L, JhawarSachin R, KaneMichael P, KaufmanHoward L, KohlhappFrederick J, KuzelTimothy M, LangenfeldJohn, LasfarAhmed, LeeLeonard Y, LeeMichael, LiShengguo, MalhotraJyoti, MarzoAmanda L, MedinaDaniel J, NewmanJenna H, NowickiChristina, ParasJoyce, PepeRussell, RabsonArnold B, RedondoRaquel E, ReiserJochen, RossiMarco, RotterDavid, RudraJai S, RuizEmily S, Sant'AngeloDerek B, SchenkelJason M, SilkAnn W, SingerEric A, TarabichiSaeed, ThomasPaul G, WangShang-Jui, ZlozaAndrew

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study demonstrated that unadjuvanted seasonal influenza vaccination administered intratumorally, but not intramuscularly, converts 'cold' tumors to 'hot', generates systemic CD8+ T cell-mediated antitumor immunity, and sensitizes resistant tumors to checkpoint blockade. Intratumoral vaccination also provided protection against subsequent active influenza virus lung infection.
Paper Details　
Original Abstract of the Article :
Reprogramming the tumor microenvironment to increase immune-mediated responses is currently of intense interest. Patients with immune-infiltrated "hot" tumors demonstrate higher treatment response rates and improved survival. However, only the minority of tumors are hot, and a limited proportion of ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969546/

データ提供：米国国立医学図書館（NLM）

Intratumoral Injection of the Seasonal Flu Shot as Immunotherapy

The fight against cancer is a complex and evolving field, like a desert landscape where every dune holds a new challenge. This study explores a novel approach to cancer immunotherapy, utilizing the seasonal influenza vaccine. Researchers investigated the effects of intratumoral injection of the influenza vaccine on the tumor microenvironment and its ability to enhance immune responses. The study examined the impact of this approach on tumor 'hotness,' immune cell infiltration, and response to checkpoint blockade.

Reprogramming the Tumor Microenvironment

This study presents a groundbreaking approach to cancer immunotherapy, demonstrating the potential of intratumoral influenza vaccination to 'heat up' cold tumors and enhance immune responses. The authors found that this approach led to increased immune cell infiltration and improved response to checkpoint blockade. Just as a desert oasis can transform a barren landscape, this research offers a potential way to transform the tumor microenvironment and enhance the effectiveness of immunotherapy.

Unlocking the Potential of Antipathogen Vaccines

This study suggests that antipathogen vaccines, like the seasonal influenza vaccine, may hold untapped potential as cancer immunotherapies. The researchers' findings demonstrate the importance of exploring innovative approaches to cancer treatment, utilizing existing resources in new and unexpected ways. This research is a testament to the creativity and ingenuity of scientists in their pursuit of effective cancer therapies.

Dr.Camel's Conclusion

This study provides compelling evidence that intratumoral injection of the seasonal flu shot can convert 'cold' tumors to 'hot' and enhance antitumor immune responses. This groundbreaking approach holds the potential to revolutionize cancer immunotherapy, offering new hope for patients battling this challenging disease.
Date :
  1. Date Completed 2020-04-15
  2. Date Revised 2020-05-15
Further Info :

Pubmed ID

31888983

DOI: Digital Object Identifier

PMC6969546

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・Effective treatment of flu shot
SNS
PICO Info
in preparation
Languages

English

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