A multicentre, randomized, double-masked, parallel group, vehicle-controlled phase IIb study to evaluate the safety and efficacy of 1% and 3% topical minocycline gel in patients with papulopustular rosacea.

Author: DhawanS, DraelosZ D, GraberE, LeeM S, MagrathG N, SalmanM, WebsterG

Paper Details 
Original Abstract of the Article :
BACKGROUND: Papulopustular rosacea is characterized by chronic facial erythema and inflammatory facial lesions. Minocycline has anti-inflammatory properties which may be effective in the treatment of rosacea inflammatory lesions. OBJECTIVES: To assess the safety and efficacy of once-daily topical m...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496252/

データ提供:米国国立医学図書館(NLM)

Topical Minocycline Gel for Papulopustular Rosacea: A Phase IIb Study

The skin condition papulopustular rosacea can be a real desert of discomfort, characterized by persistent facial redness and inflammatory bumps. This study explores the potential of topical minocycline gel as a treatment option for rosacea. The researchers conducted a double-blind, vehicle-controlled phase IIb study to evaluate the safety and efficacy of two different concentrations of the gel.

Minocycline Gel: A Potential Oasis for Rosacea

The results showed that both 1% and 3% minocycline gel were safe and well-tolerated. Importantly, both concentrations significantly reduced the number of inflammatory lesions compared to the placebo. The 3% concentration proved more effective in achieving success on the Investigator's Global Assessment (IGA) scale, a measure of overall rosacea severity.

Finding Relief in the Rosacea Desert

For those struggling with papulopustular rosacea, this study offers a ray of hope. Topical minocycline gel, particularly at the 3% concentration, shows promise as a treatment option. However, it is essential to consult with a dermatologist to determine if minocycline is the right treatment for you and to discuss any potential side effects.

Dr.Camel's Conclusion

This study suggests that topical minocycline gel could be a valuable tool in the treatment of papulopustular rosacea. While more research is needed, the findings offer a potential oasis for those seeking relief from this frustrating condition. Remember, as with any treatment, it's crucial to consult with a healthcare professional to determine the best approach for your individual needs.

Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

31907924

DOI: Digital Object Identifier

PMC7496252

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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