Effective treatment of rosacea: A Synthesis of Findings from 58 Studies

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Original Abstract of the Article

Major Research Findings

Research on rosacea has yielded a variety of treatment options, each targeting different aspects of the condition. 11 highlights the effectiveness of camphor oil and metronidazole in treating rosacea. 56 shows promise for paroxetine in treating persistent redness associated with rosacea. A comprehensive review in 25 indicates that topical metronidazole and azelaic acid are more effective than placebos. Furthermore, 37 suggests that ivermectin is superior to placebo and slightly more effective than metronidazole. These studies demonstrate a range of potential treatment avenues for rosacea symptoms.

Treatment Summary

11 highlights the effectiveness of camphor oil and metronidazole in treating rosacea. 56 shows promise for paroxetine in treating persistent redness associated with rosacea. A comprehensive review in 25 indicates that topical metronidazole and azelaic acid are more effective than placebos. Furthermore, 37 suggests that ivermectin is superior to placebo and slightly more effective than metronidazole.

Benefits and Risks

Benefit Summary

Rosacea treatment offers various potential benefits. For instance, 25 demonstrates the effectiveness of metronidazole and azelaic acid over placebos, suggesting their ability to alleviate rosacea symptoms. 37 points to ivermectin's efficacy, both exceeding placebo and potentially outperforming metronidazole. These findings collectively suggest that these treatments may improve rosacea symptoms.

Risk Summary

Rosacea treatments can also carry risks. For example, antibiotic use may lead to antibiotic resistance and potential side effects. 55 mentions potential side effects of medication used for rosacea. When considering treatment, it's vital to weigh risks against benefits and consult a physician.

Comparison Between Studies

Research Similarities

Multiple studies are dedicated to finding effective treatments for rosacea symptoms. These studies collectively contribute to the development and improvement of treatment options for this condition.

Research Differences

Studies often focus on different types of rosacea and utilize various treatment methods. Additionally, study designs and evaluation methods vary, leading to differing results. Therefore, comprehensive interpretation of these findings and selection of the most appropriate treatment is essential.

Consistency and Contradictions in Results

Several studies indicate the effectiveness of treatments such as metronidazole and azelaic acid in managing rosacea symptoms. However, results can vary, and these treatments may not be universally effective for all patients. Further research is necessary to fully understand the effectiveness and safety of these treatments.

Applying Research Findings to Real Life: Key Considerations

Rosacea treatment methods vary based on individual symptoms and skin type. It's crucial to consult a physician before initiating treatment and choosing the most appropriate option. During treatment, adhere to medical guidance and avoid self-adjusting or discontinuing treatment without physician consultation.

Limitations of Current Research

Research on rosacea treatments remains ongoing. Long-term effectiveness and safety require further study. The exact mechanisms and causes of rosacea are not fully understood. Addressing these gaps in knowledge is vital for developing even more effective and safe treatment options.

Future Research Directions

The following research avenues are crucial for advancing rosacea treatment: * Elucidating the mechanisms underlying rosacea * Developing novel treatment methods * Evaluating long-term effectiveness and safety of existing treatments * Developing therapies that improve patients' quality of life

Conclusion

Rosacea treatment involves a variety of approaches. Treatments such as metronidazole and azelaic acid have shown promise in managing rosacea symptoms, but these treatments may not be universally effective. Weighing risks and benefits through consultation with a physician is crucial. Further research is essential for developing even more effective and safe treatment options for rosacea.

Treatment List

Metronidazole, Azelaic acid, Ivermectin, Paroxetine, Camphor oil, Doxycycline, Tetracycline, Minocycline, Azithromycin, Clarithromycin, Acne, Erythema, Rosacea, Light therapy

Keywords
Benefit Keywords
Rosacea treatment
1
Effective treatment
2
Effective treatment
Safe treatment
3
Acne rosacea improvement
4
Rosacea remission
5
Reduced papules
Reduced pustules
6
Effective rosacea treatment
7
Improved erythema
Reduced inflammatory lesion count
Therapeutic success
Well tolerated
8
Rosacea treatment
9
Rosacea treatment
Well tolerated
10
Rosacea treatment
11
Reduced rosacea lesions
12
Reduced inflammation
Rosacea treatment
14
Effective rosacea treatment
Well tolerated
15
Effective for rosacea
16
Rosacea treatment
17
Improved rosacea
18
Rosacea treatment
19
Improved rosacea symptoms
20
Complete remission
Marked improvement
Reduced lesions
21
Treatment for rosacea
22
Enhanced PDL effect
23
Rosacea treatment
24
Improved rosacea treatment
25
Improved rosacea
Reduced erythema
26
Improved skin hydration
Reduced burning
Reduced erythema
Reduced flushing
Reduced stinging
27
Potential rosacea treatment
Treatment of papulopustular acne rosacea
28
Rosacea treatment
29
Rosacea treatment
30
Rosacea treatment
Safe and effective
32
Good tolerability
Modest improvement
33
Improved quality of life
Improved rosacea
34
PPR treatment
35
Rosacea treatment
36
Effective treatment
37
Facial erythema improvement
Papule/pustule counts improvement
38
Reduced facial redness
39
Rosacea remission
40
Rosacea treatment
41
Improved erythema
Improved inflammatory lesions
Patient satisfaction
42
Oxymetazoline efficacy
43
Erythema reduction
44
Rosacea treatment
45
Rosacea treatment
46
Rosacea improvement
Rosacea lesion reduction
47
Improved rosacea
48
Erythema reduction
Flushing reduction
49
LLBT for rosacea
50
Rosacea treatment
51
ETR treatment
Warmth and burning reduction
52
Acne reduction
53
Quality of life
Rosacea improvement
54
Effective treatment
Well tolerated
56
Rosacea treatment
57
Ocular rosacea treatment
58
Risk Keywords
Minimal side effects
4
None reported
8
Unclear which treatments are best
9
Skin irritation
12
Mild gastric upset
15
Mild and transient side effects
18
Side effects
19
None reported
20
Dermatitis facialis
21
Skin irritation
26
Difficult rosacea treatment
Not specified
Systemic medication reluctance
28
Inflammation
Intolerance
29
Dermatologic adverse events
32
Treatment-related AEs
33
AEs
35
Mild
transient adverse events
39
Bradycardia
Hypotension
49
Low-to-moderate evidence
No single modality complete resolution
50
Redness worsening
52
Adverse effects
53
Adverse reactions
54
Rosacea in Japan
55
Dizziness
Dyspepsia
Lethargy
Muscle tremors
Nausea
56
Delayed diagnosis
58
Literature analysis of 58 papers
Positive Content
57
Neutral Content
1
Negative Content
0
Article Type
46
6
12
9
58
1.

A comparison of the efficacy of topical tretinoin and low-dose oral isotretinoin in rosacea.

Author: ErtlG A, LevineN, KligmanA M

Rosacea treatment

This randomized, double-blind trial of 22 patients with severe or recalcitrant rosacea found that both low-dose oral isotretinoin and topical tretinoin were effective in treating rosacea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Double-blind study versus excipient of 0.75% metronidazole gel in the treatment of rosacea].

Author: EspagneE, GuillaumeJ C, ArchimbaudA, BaspeyrasM, BoitierF, BussièreM, ChamberlinJ, CoinA, Di CrescenzoM C, DolivoM

Effective treatment

This study tested the effectiveness of an 0.75% metronidazole gel in treating rosacea, an alternative to oral tetracyclines and metronidazole which can have significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

3.

Treatment of rosacea: topical clindamycin versus oral tetracycline.

Author: WilkinJ K, DeWittS

Effective treatment
Safe treatment

Topical clindamycin in a lotion base is a safe and effective alternative to oral tetracycline therapy in the treatment of rosacea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

A pilot study of 5 percent permethrin cream versus 0.75 percent metronidazole gel in acne rosacea.

Author: SignoreR J

Acne rosacea improvement
Minimal side effects

A pilot study comparing topical 5% permethrin cream and 0.75% metronidazole gel for acne rosacea showed moderate improvement on both sides of the face with minimal adverse effects in five patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Topical metronidazole maintains remissions of rosacea.

Author: DahlM V, KatzH I, KruegerG G, MillikanL E, OdomR B, ParkerF, WolfJ E, AlyR, BaylesC, ReusserB, WeidnerM, ColemanE, PatrignelliR, TuleyM R, BakerM O, HerndonJ H, CzernielewskiJ M

Rosacea remission

This study found that continued treatment with topical metronidazole gel alone maintains remission of moderate to severe rosacea in a majority of subjects previously treated with oral tetracycline and topical metronidazole gel.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

[Rilmenidine in rosacea: a double-blind study versus placebo].

Author: GrosshansE, MichelC, ArcadeB, CribierB

Reduced papules
Reduced pustules

This study investigated the efficacy of rilmenidine in treating flushes associated with rosacea, a condition often treated with cyclines and metronidazole.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

7.

Randomized placebo-controlled trial of metronidazole 1% cream with sunscreen SPF 15 in treatment of rosacea.

Author: TanJ K L, GirardC, KrolA, MurrayH E, PappK A, PoulinY, ChinD A, JeandupeuxD

Effective rosacea treatment

Metronidazole 1% cream combined with sunscreen SPF 15 was effective and safe for treating moderate to severe rosacea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies.

Author: ThiboutotDiane, Thieroff-EkerdtRuth, GraupeKlaus

Improved erythema
Reduced inflammatory lesion count
Therapeutic success
Well tolerated
None reported

15% azelaic acid (AzA) gel was more effective than vehicle in treating moderate, papulopustular rosacea. AzA gel resulted in significantly higher reductions in inflammatory lesion count, improvement in erythema, and therapeutic success compared to vehicle. AzA gel was well tolerated and safe, with no serious treatment-related adverse events reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Interventions for rosacea.

Author: van ZuurenE J, GraberM A, HollisS, ChaudhryM, GuptaA K

Rosacea treatment
Unclear which treatments are best

Rosacea is a common skin condition that affects the face, causing redness, bumps, and dilated blood vessels. The eyes can also be affected. The cause of rosacea is unknown, but it can be managed with treatment in most cases. While many treatments are available, there is no clear agreement on the best options for different types of rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Double-blind, randomized, vehicle-controlled clinical trial of once-daily benzoyl peroxide/clindamycin topical gel in the treatment of patients with moderate to severe rosacea.

Author: BrenemanDebra, SavinRonald, VandePolChristine, VamvakiasGeorge, LevySharon, LeydenJames

Rosacea treatment
Well tolerated

Topical application of a combination of 5% benzoyl peroxide and 1% clindamycin was effective and well tolerated in patients with moderate to severe rosacea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Treatment of human Demodex folliculorum by camphor oil and metronidazole.

Author: El-ShazlyAtef M, HassanAshraf A, SolimanMohamed, MorsyGaza H, MorsyTosson A

Rosacea treatment

Topical application of diluted camphor oil with glycerol and oral metronidazole were effective in treating erythematotelangiectatic rosacea in 15 female patients, with no reported side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Adapalene vs. metronidazole gel for the treatment of rosacea.

Author: AltinyazarH Cevdet, KocaRafet, TekinNilgün Solak, EştürkEmel

Reduced rosacea lesions
Skin irritation

Adapalene gel is a well-tolerated and effective alternative topical treatment for papulopustular rosacea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Interventions for rosacea.

Author: van ZuurenE J, GraberM A, HollisS, ChaudhryM, GuptaA K, GoverM

The quality of studies evaluating rosacea treatments was generally poor. Topical metronidazole and azelaic acid are effective, while there is some evidence that oral metronidazole and tetracycline are effective. There is insufficient evidence concerning the effectiveness of other treatments. Good RCTs looking at these treatments are urgently needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea.

Author: WolfJohn E, KerroucheNabil, ArsonnaudStephanie

Reduced inflammation
Rosacea treatment

This study compared the effectiveness of metronidazole 1% gel and azelaic acid 15% gel in treating moderate rosacea, finding that both treatments showed similar reductions in inflammatory lesions and high success rates in reducing erythema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Oral zinc sulfate in the treatment of rosacea: a double-blind, placebo-controlled study.

Author: SharquieKhalifa E, NajimRafid A, Al-SalmanHala N

Effective rosacea treatment
Well tolerated
Mild gastric upset

Zinc sulfate was found to be a safe, effective, and well-tolerated treatment for rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Systematic review of rosacea treatments.

Author: van ZuurenEsther J, GuptaAditya K, GoverMelissa D, GraberMark, HollisSally

Effective for rosacea

Topical metronidazole and azelaic acid are effective treatments for rosacea. More research is needed to evaluate the efficacy and safety of other therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial.

Author: AkhyaniMaryam, EhsaniAmir Houshang, GhiasiMaryam, JafariAlireza Keshtcar

Rosacea treatment

Azithromycin, a macrolide antibiotic, is being investigated as a potential alternative treatment for rosacea.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial.

Author: LeeD H, LiK, SuhD H

Improved rosacea
Mild and transient side effects

Pimecrolimus 1% cream was effective and well-tolerated for the treatment of steroid-induced rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Comparative study of some treatment modalities of rosacea.

Author: MostafaF F, El HarrasM A, GomaaS M, Al MokademS, NassarA A, Abdel GawadE H

Rosacea treatment
Side effects

Azelaic acid 20% cream was more effective than metronidazole 0.75% cream or permethrin 5% cream in treating inflammatory lesions of rosacea, with a similar safety profile and increased patient satisfaction.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

A comparison of metronidazole 1% cream and pimecrolimus 1% cream in the treatment of patients with papulopustular rosacea: a randomized open-label clinical trial.

Author: KocaR, AltinyazarH C, AnkaraliH, MuhtarS, TekinN S, CinarS

Improved rosacea symptoms
None reported

Both topical pimecrolimus 1% cream and metronidazole 1% cream were very effective in the treatment of papulopustular rosacea (PR). There were no significant differences between the treatments in inflammatory lesion counts, overall erythema severity scores, and Physician's Global Assessment (PGA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Systemic isotretinoin in the treatment of rosacea - doxycycline- and placebo-controlled, randomized clinical study.

Author: GollnickHarald, Blume-PeytaviUlrike, SzabóEörs Lāszlō, MeyerKarl-Gustav, HauptmannPetra, PoppGeorg, SebastianMichael, ZwingersThomas, WillersChristoph, von der WethRenate

Complete remission
Marked improvement
Reduced lesions
Dermatitis facialis

This double-blinded randomized controlled trial evaluated the efficacy and safety of isotretinoin for treating rosacea subtype II and III in 573 patients. Isotretinoin at a dose of 0.3 mg/kg was found to be effective and well-tolerated, showing non-inferiority to doxycycline.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Efficacy of topical azelaic acid (AzA) gel 15% plus oral doxycycline 40 mg versus metronidazole gel 1% plus oral doxycycline 40 mg in mild-to-moderate papulopustular rosacea.

Author: Del RossoJames Q, BruceSuzanne, JarrattMichael, MenterAlan, StaedtlerGerald

Treatment for rosacea

This exploratory study assessed the safety, effectiveness, and speed of onset of two common topical agents for the treatment of rosacea: azelaic acid gel (AzA) 15% and metronidazole gel 1%.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Interventions for rosacea.

Author: van ZuurenEsther J, KramerSharon, CarterBen, GraberMark A, FedorowiczZbys

Rosacea treatment

Rosacea, a common skin condition affecting the face, causes redness, pimples, and dilated blood vessels. While several treatments exist, the most effective options remain unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Effective and evidence-based management strategies for rosacea: summary of a Cochrane systematic review.

Author: van ZuurenE J, KramerS F, CarterB R, GraberM A, FedorowiczZ

Improved rosacea treatment

This updated review assesses the evidence for the efficacy and safety of various treatments for rosacea, a common chronic skin disease. The review found some evidence supporting the effectiveness of topical metronidazole, azelaic acid, and doxycycline (40mg) for moderate to severe rosacea and ciclosporin 0.05% ophthalmic emulsion for ocular rosacea. Further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Efficacy of a novel rosacea treatment system: an investigator-blind, randomized, parallel-group study.

Author: LeydenJames J

Improved rosacea
Reduced erythema
Skin irritation

A rosacea treatment system containing cleanser, metronidazole gel, complexion corrector, and sunscreen was found to be more effective and tolerable than metronidazole gel alone or metronidazole gel with standard skin care in treating mild to moderate rosacea. The rosacea treatment system showed a 90% global improvement rate compared to 60% and 67% for the other groups, and erythema was significantly lower from day 14 onward. The system also caused less skin irritation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea.

Author: BerardescaEnzo, IorizzoMatilde, AbrilElva, GuglielminiGiancarlo, CaseriniMaurizio, PalmieriRenata, PiérardGérald E

Improved skin hydration
Reduced burning
Reduced erythema
Reduced flushing
Reduced stinging

A cream containing 5% potassium azeloyl diglycinate and 1% hydroxypropyl chitosan effectively reduced erythema and other symptoms in patients with rosacea. The cream was well tolerated and showed promise for controlling signs and symptoms of rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks.

Author: ChangAnne Lynn S, Alora-PalliMaria, LimaXinaida T, ChangTiffany C, ChengCarol, ChungConnie M, AmirOmar, KimballAlexa B

Potential rosacea treatment
Treatment of papulopustular acne rosacea
Difficult rosacea treatment
Not specified
Systemic medication reluctance

A type of rosacea called papulopustular rosacea can be difficult to treat, and many patients avoid oral medications. A topical combination of clindamycin phosphate 1.2% and tretinoin 0.025% gel is effective for acne and might be helpful for rosacea because both conditions share similar features.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea.

Author: JacksonJ Mark, KircikLeon H, LorenzDouglas J

Rosacea treatment

Rosacea, a common skin condition causing redness, bumps, and other facial skin changes, is often treated with minocycline, an antibiotic. This study explores the use of a new, slow-release form of minocycline (45mg tablet) alone or with azelaic acid, another medication, to treat rosacea.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Comparative pharmacokinetics and bioavailability of brimonidine following ocular and dermal administration of brimonidine tartrate ophthalmic solution and gel in patients with moderate-to-severe facial erythema associated with rosacea.

Author: BenkaliK, LeoniM, RonyF, BouerR, FernandoA, GraeberM, WagnerN

Topical brimonidine tartrate gel showed a lower systemic exposure than the ophthalmic solution.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies.

Author: SteinLinda, KircikLeon, FowlerJoseph, TanJerry, DraelosZoe, FleischerAlan, AppellMelanie, SteinhoffMartin, LyndeCharles, LiuHong, JacovellaJean

Rosacea treatment
Safe and effective
Dermatologic adverse events

Ivermectin 1% cream was effective and safe in treating inflammatory lesions of papulopustular rosacea.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

A multicentre, randomized, placebo-controlled trial establishing the treatment effect of TDT 068, a topical formulation containing drug-free ultra-deformable phospholipid vesicles, on the primary features of erythematotelangiectatic rosacea.

Author: LugerT, PeukertN, RotherM

Good tolerability
Modest improvement
Treatment-related AEs

The drug-free gel TDT 068 was well-tolerated and showed modest improvements in symptoms of erythematotelangiectatic rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Clinical and experimental assessment of the effects of a new topical treatment with praziquantel in the management of rosacea.

Author: BribecheMohamed Ridha, FedotovValery P, GladichevVitaly V, PukhalskayaDaria M, KolitchevaNatalia L

Improved quality of life
Improved rosacea

A 16-week, randomized, single-blind pilot study evaluated the efficacy and safety of 3% praziquantel (PZQ) ointment in treating rosacea. The study found that 3% PZQ ointment was significantly more effective than placebo in improving rosacea symptoms and patients' quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Superiority of ivermectin 1% cream over metronidazole 0·75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial.

Author: TaiebA, OrtonneJ P, RuzickaT, RoszkiewiczJ, Berth-JonesJ, PeironeM H, JacovellaJ,

PPR treatment
AEs

Ivermectin 1% cream was found to be significantly more effective than metronidazole 0.75% cream in reducing inflammatory lesions in patients with moderate to severe papulopustular rosacea after 16 weeks of treatment. Ivermectin 1% cream also resulted in higher patient satisfaction.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Interventions for rosacea.

Author: van ZuurenEsther J, FedorowiczZbys, CarterBen, van der LindenMireille M D, CharlandLyn

Rosacea treatment

Rosacea is a common and persistent skin condition affecting the face, causing redness, bumps, pimples, and visible blood vessels. The eyes can also be affected, and in some cases, the skin thickens and enlarges, especially on the nose. While various treatments are available, the most effective options are unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Interventions for rosacea: abridged updated Cochrane systematic review including GRADE assessments.

Author: van ZuurenE J, FedorowiczZ

Effective treatment

Rosacea is a common skin condition. This updated Cochrane review summarizes the evidence for various treatment options, including topical medications, oral medications, and laser therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Phytochemical and Botanical Therapies for Rosacea: A Systematic Review.

Author: FiskWhitney A, Lev-TovHadar A, ClarkAshley K, SivamaniRaja K

Facial erythema improvement
Papule/pustule counts improvement

Botanical and cosmeceutical therapies are widely used for rosacea, but many lack rigorous scientific evidence. This study reviews clinical studies that have examined the effectiveness of botanical agents for rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Brimonidine gel 0.33% rapidly improves patient-reported outcomes by controlling facial erythema of rosacea: a randomized, double-blind, vehicle-controlled study.

Author: LaytonA M, SchallerM, HomeyB, HofmannM A, BewleyA P, LehmannP, NohlgårdC, SarwerD B, KerroucheN, MaY M

Reduced facial redness
Mild
transient adverse events

This study found that brimonidine gel 0.33% was effective in reducing facial redness in patients with rosacea and improved patient-reported outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study.

Author: TaiebA, KhemisA, RuzickaT, Barańska-RybakW, Berth-JonesJ, SchauberJ, BriantaisP, JacovellaJ, PasseronT,

Rosacea remission

Ivermectin 1% cream was found to be more effective than metronidazole 0.75% cream in extending remission of papulopustular rosacea (PPR) after treatment cessation.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

The Role of Polyphenols in Rosacea Treatment: A Systematic Review.

Author: SaricSuzana, ClarkAshley K, SivamaniRaja K, LioPeter A, Lev-TovHadar A

Rosacea treatment

Rosacea is a skin condition causing redness, broken blood vessels, bumps, and other symptoms. Plant-based treatments are often used. This review examines the use of polyphenols, compounds found in plants, to treat rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Treatment of Rosacea With Concomitant Use of Topical Ivermectin 1% Cream and Brimonidine 0.33% Gel: A Randomized, Vehicle-controlled Study.

Author: GoldLinda Stein, PappKim, LyndeCharles, LainEdward, GooderhamMelinda, JohnsonSandra, KerroucheNabil

Improved erythema
Improved inflammatory lesions
Patient satisfaction

Combining ivermectin 1% cream and brimonidine 0.33% gel was more effective in treating rosacea than either treatment alone. Early introduction of brimonidine may accelerate treatment success.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

Phase 2 Randomized, Dose-Ranging Study of Oxymetazoline Cream for Treatment of Persistent Facial Erythema Associated With Rosacea.

Author: DuBoisJanet, DoverJeffrey S, JonesTerry M, WeissRobert A, BerkDavid R, AhluwaliaGurpreet

Oxymetazoline efficacy

This phase 2 study evaluated the optimal dosing regimen of oxymetazoline cream for persistent facial erythema of rosacea. 356 patients were randomly assigned to oxymetazoline cream (0.5%, 1.0%, or 1.5%) or vehicle, administered once or twice daily. Oxymetazoline 1.0% once daily provided the optimal dosing regimen.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Clinically Relevant Reduction in Persistent Facial Erythema of Rosacea on the First Day of Treatment With Oxymetazoline Cream 1.0.

Author: TanghettiEmil A, DoverJeffrey S, GoldbergDavid J, DhawanSunil S, LuoLei, BerkDavid R, AhluwaliaGurpreet, AlvandiNancy

Erythema reduction

Topical oxymetazoline cream 1.0% demonstrated clinically meaningful improvement in persistent erythema of rosacea after the first dose.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea.

Author: BageorgouFotini, VasalouVarvara, TzanetakouVasiliki, KontochristopoulosGeorge

Rosacea treatment

Tranexamic acid solution applied topically to affected areas effectively treated erythematotelangiectatic rosacea. The use of tranexamic acid with microneedling was found to be more effective than tranexamic acid alone. The improvement lasted more than four months and the treatment was well tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

The efficacy and safety of permethrin 2.5% with tea tree oil gel on rosacea treatment: A double-blind, controlled clinical trial.

Author: EbneyaminElnaz, MansouriParvin, RajabiMehdi, QomiMahnaz, AsgharianRamin, AzizianZahra

Rosacea treatment

Permethrin 2.5% with tea tree oil (TTO) gel demonstrated good efficacy and safety in rosacea. This topical gel inhibited the inflammatory effects of rosacea and reduced *Demodex* mite density.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

A multicentre, randomized, double-masked, parallel group, vehicle-controlled phase IIb study to evaluate the safety and efficacy of 1% and 3% topical minocycline gel in patients with papulopustular rosacea.

Author: WebsterG, DraelosZ D, GraberE, LeeM S, DhawanS, SalmanM, MagrathG N

Rosacea improvement
Rosacea lesion reduction

Topical minocycline gel at concentrations of 1% and 3% was safe and tolerable in patients with papulopustular rosacea. Both concentrations significantly decreased inflammatory lesion counts, with a larger proportion of patients achieving success at week 12 with 3% concentration.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Pulsed dye laser alone versus its combination with topical ivermectin 1% in treatment of Rosacea: a randomized comparative study.

Author: OsmanMaiAbdelraouf, ShokeirHisham A, HassanArwa Mohamed, Atef KhalifaMarwa

Improved rosacea

Pulsed dye laser (PDL) treatment for rosacea was effective, and it may be more effective when combined with ivermectin 1% cream.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

49.

Use of beta-blockers for rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action.

Author: LoggerJade G M, OlydamJill I, DriessenRieke J B

Erythema reduction
Flushing reduction
Bradycardia
Hypotension

Oral beta-blockers may be an effective treatment option for rosacea patients with facial erythema and flushing unresponsive to conventional therapy, although larger prospective trials are needed for validation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Efficacy and tolerability of a detergent and care component for rosacea patients: A split-face, vehicle-controlled, randomized trial.

Author: GuertlerAnne, NiesertAnne Charlotte, WilhelmKlaus-Peter, KnuhrKatrin, BrandtMarianne, FrenchLars E, ReinholzMarkus

Rosacea treatment

Treating the redness and symptoms of rosacea is difficult. Cosmeceuticals, products that combine skincare and active ingredients like plant-based substances, are becoming more popular. However, we need more research to determine how well they work and what their limitations are.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

A randomized, controlled, split-face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea.

Author: WeiDanfeng, HamblinMichael R, WenXiang

ETR treatment
Warmth and burning reduction
Redness worsening

Topical timolol maleate 0.5% was safe and effective for the treatment of erythematotelangiectatic rosacea (ETR) in a small study. Participants showed significant improvement in erythema and warmth/burning sensations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Adjunctive treatment for acne vulgaris by tranexamic acid.

Author: CharoenwattanayothinAnshittha, SaiwichaiTawee, ChaichalotornkulSirintip

Acne reduction
Adverse effects

Topical 10% tranexamic acid serum was effective in reducing inflammatory acne.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

54.

Analysis of the Effect of DPL Combined with Clarithromycin in the Therapy and Improvement of Rosacea.

Author: YanFang, PengChao

Quality of life
Rosacea improvement
Adverse reactions

A combination of DPL and clarithromycin was found to be effective in treating rosacea patients, improving clinical symptoms and therapeutic effect, with a low incidence of adverse reactions. This combination therapy demonstrated good prognosis for patients with rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

55.

Perspectives on rosacea patient characteristics and quality of life using baseline data from a phase 3 clinical study conducted in Japan.

Author: YamasakiKenshi, MiyachiYoshiki

Rosacea in Japan

This study investigates the prevalence, characteristics, and triggers of rosacea in Japanese patients. The findings suggest that rosacea may be underdiagnosed and undertreated in Japan, highlighting the need for improved awareness and standardized treatment approaches.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

56.

Paroxetine is an effective treatment for refractory erythema of rosacea: Primary results from the Prospective Rosacea Refractory Erythema Randomized Clinical Trial.

Author: WangBen, HuangYingxue, TangYan, ZhaoZhixiang, ShiWei, JianDan, LiuFangfen, GaoQiong, WangPeiru, YangJie, LiLin, XieHongfu, LiJi

Effective treatment
Well tolerated
Dizziness
Dyspepsia
Lethargy
Muscle tremors
Nausea

A 12-week course of paroxetine was found to be an effective and well-tolerated treatment for moderate-to-severe erythema of rosacea. Paroxetine significantly improved erythema and flushing, as well as burning sensation and depression. The most common side effects were dizziness, lethargy, nausea, dyspepsia, and muscle tremors.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

A Prospective Randomized Controlled Pilot Study to Assess the Response and Tolerability of Cold Atmospheric Plasma for Rosacea.

Author: HofmeyerStella, WeberFrank, GerdsSandra, EmmertSteffen, ThiemAlexander

Rosacea treatment

Rosacea is a common skin condition that affects the face. Treating rosacea can be difficult because it has many causes. A new treatment called cold atmospheric plasma (CAP), which has shown promise for healing wounds and treating other skin conditions, is being investigated as a potential therapy for rosacea.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

58.

Treatment of pediatric ocular rosacea: A systematic review.

Author: KhaslavskyS, StarkeyS Y, AvrahamS, KashetskyN, MukovozovI

Ocular rosacea treatment
Delayed diagnosis

Systemic antibiotics, particularly doxycycline, were the most common treatment for pediatric ocular rosacea. Early diagnosis is crucial due to the high prevalence of delayed diagnosis in this population.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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