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Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Function and CT Coronary Angiogram (CorCTCA) study.

Author: AdamsJacqueline, BerryColin, ByrneJohn, FordThomas J, HargreavesAllister, McConnachieAlex, McDermottMichael, McEntegartMargaret, MessowClaudia-Martina, MorrowAndrew, OldroydKeith G, RoditiGiles, SidikNovalia P, StoboDavid, WuOlivia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

CorCTCA will prospectively characterize the prevalence of disease endotypes in INOCA and determine the clinical value of stratified medicine in this population. This prospective, multicenter, randomized, blinded, sham-controlled trial will assess the impact of stratified medicine on angina symptoms and quality of life in patients with INOCA.
Paper Details　
Original Abstract of the Article :
UNLABELLED: Microvascular and/or vasospastic anginas are relevant causes of ischemia with no obstructive coronary artery disease (INOCA) in patients after computed tomography coronary angiography (CTCA). OBJECTIVES: Our research has 2 objectives. The first is to undertake a diagnostic study, and th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029345/

データ提供：米国国立医学図書館（NLM）

Investigating Microvascular Function in Patients with Chest Pain: A Comprehensive Study Design

In the vast desert of cardiovascular research, scientists are constantly seeking to understand the intricate mechanisms of heart disease. This study, like a lone camel traversing the sands of coronary artery disease, explores the role of microvascular function in patients with chest pain who do not have obstructive coronary artery disease (INOCA). The researchers designed a comprehensive study involving both a diagnostic phase and a clinical trial of stratified medicine, aiming to better characterize the prevalence of different disease endotypes in INOCA and assess the value of personalized treatment approaches.

Unraveling the Complexity of Chest Pain: A Stratified Medicine Approach

The study's design reflects the growing understanding of the heterogeneity of chest pain. The researchers are using a stratified medicine approach to tailor treatment based on the specific disease endotype, recognizing that patients with INOCA may have different underlying causes for their symptoms. This approach aims to optimize treatment outcomes by addressing the specific needs of each patient.

Improving Cardiac Care: A Journey of Personalized Treatment

This study highlights the importance of a personalized approach to treating chest pain. It's crucial to consult with a qualified healthcare professional for a thorough evaluation, including advanced diagnostic testing like CT coronary angiography and invasive coronary angiography, to determine the underlying cause of chest pain. Personalized treatment strategies tailored to the specific disease endotype can potentially lead to more effective and targeted care.

Dr.Camel's Conclusion

This study, like a compass guiding researchers through the vast desert of cardiovascular research, explores the complexities of chest pain and the potential of a stratified medicine approach for optimizing patient care. The study's findings hold promise for improving our understanding of heart disease and developing more effective treatment strategies for patients with INOCA.

Date :
  1. Date Completed 2020-04-28
  2. Date Revised 2023-11-13
Further Info :

Pubmed ID

31911341

DOI: Digital Object Identifier

PMC7029345

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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