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Demonstration of a Na+: Mg2+ exchange in human red cells by its sensitivity to tricyclic antidepressant drugs.

Author: FérayJ C, GarayR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Certain tricyclic antidepressants, including imipramine and dothiepine, inhibited magnesium efflux in human red blood cells at concentrations similar to those of known transport inhibitors. Imipramine, in particular, inhibited sodium influx in a way that was coupled with magnesium efflux.
Paper Details　
Original Abstract of the Article :
Iminodibenzyl-, iminostilbene-, dibenzocycloheptadiene-, dibenzooxepine- and dibenzothiepine-derivatives of tricyclic antidepressant drugs were able to inhibit Na+-stimulated Mg2+ efflux in human erythrocytes at concentrations of 10(-5) -10(-3) mol/l. Tricyclic antidepressant drugs belonging to othe...See full text at original site
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引用元：
https://doi.org/10.1007/BF00173409

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of the Na+: Mg2+ Exchange in Red Blood Cells

The intricate workings of our bodies are a fascinating subject of study. This research dives into the complex world of ion transport within red blood cells, specifically focusing on the Na+: Mg2+ exchange. The researchers investigated the effects of various tricyclic antidepressant drugs on this exchange, finding that certain drugs could inhibit the movement of magnesium ions out of red blood cells. This discovery is like finding a hidden pathway through the intricate network of cellular processes.

Tricyclic Antidepressants: A New Perspective on Ion Transport

This research offers a new perspective on the role of tricyclic antidepressant drugs. The researchers found that certain drugs could impact the Na+: Mg2+ exchange in red blood cells. This discovery is like uncovering a hidden treasure trove of knowledge about the intricate workings of our bodies.

Understanding Ion Transport: A Key to Better Health

This research underscores the importance of understanding ion transport in cells. The Na+: Mg2+ exchange, a vital process, is influenced by various factors, including certain medications. This research is like a camel guide leading us through the desert of cellular processes, offering a deeper understanding of the intricate mechanisms that maintain our health.

Dr.Camel's Conclusion

This research, like a camel trekking through a vast desert, has explored the complex world of ion transport in red blood cells. The researchers' findings provide valuable insights into the impact of tricyclic antidepressant drugs on the Na+: Mg2+ exchange. This research is a reminder of the intricate and interconnected nature of our bodies and highlights the importance of understanding these complex processes.

Date :
  1. Date Completed 1988-12-30
  2. Date Revised 2019-07-25
Further Info :

Pubmed ID

3194041

DOI: Digital Object Identifier

10.1007/BF00173409

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