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Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis.

Author: AnnibaleLuciano, BhattacharyyaSagnik, Blest-HopleyGrace, BrammerMick, ColizziMarco, GiampietroVincent, O'NeillAisling, WilsonRobin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cannabidiol (CBD) showed an antipsychotic effect in patients with established psychosis, possibly by normalizing brain activation in the mediotemporal and prefrontal regions and reducing mediotemporal-striatal functional connectivity. CBD also caused trend-level symptom reduction.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Recent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient present in cannabis extract, has an antipsychotic effect in people with established psychosis. However, the effect of CBD on the neurocognitive mechanisms underlying psychosis is unknown. METHODS: Patients wi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31994476

データ提供：米国国立医学図書館（NLM）

Cannabidiol: A New Frontier in the Treatment of Psychosis

The human brain, a complex and intricate organ, is like a vast desert with hidden oases of potential. This research explores the potential of cannabidiol (CBD), a non-psychoactive compound found in cannabis, to alleviate symptoms of psychosis. The study delves into the neurocognitive mechanisms underlying psychosis and investigates how CBD might affect brain activity and connectivity.

CBD: A Potential Pathway to Restoring Brain Balance

The research suggests that CBD may exert its antipsychotic effects by normalizing activity in key brain regions involved in psychosis, including the mediotemporal and prefrontal cortex. The study also highlights the potential role of CBD in modulating connectivity between the mediotemporal and striatal regions, suggesting that CBD might influence the communication networks within the brain. This offers a promising glimpse into the potential of CBD as a therapeutic agent for psychosis.

Navigating the Complexities of Psychosis: The Promise of CBD

This research underscores the importance of exploring novel therapeutic options for psychosis, a condition that can significantly impact individuals and their families. The study's findings regarding CBD's potential to restore brain balance offer a beacon of hope for those seeking relief from the debilitating symptoms of psychosis. Remember, just as a desert oasis provides relief from the harsh conditions of the desert, CBD might offer a path to improved well-being for those struggling with psychosis.

Dr. Camel's Conclusion

The human brain, like a vast desert with hidden oases, holds immense potential. This study suggests that CBD, a compound found in cannabis, might offer a new path to alleviating symptoms of psychosis by restoring balance and communication within the brain. As we journey through the intricate world of the human mind, exploring novel therapies like CBD can help us uncover hidden oases of hope and well-being for those grappling with the challenges of psychosis.

Date :
  1. Date Completed 2021-11-15
  2. Date Revised 2021-11-15
Further Info :

Pubmed ID

31994476

DOI: Digital Object Identifier

S0033291719003519

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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