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Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study.

Author: Bueno-OrovioAlfonso, CerbaiElisabetta, CoppiniRaffaele, FerrantiniCecilia, FlinkLaura, MugelliAlessandro, OlivottoIacopo, PalandriChiara, PavoneFrancesco Saverio, PionerJosè Manuel, PoggesiCorrado, RiedyKatherine, SacconiLeonardo, SantiniLorenzo, ScardigliMarina, SherridMark V, StefànoPierluigi, VitaleGiulia, WangZhinuo J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Disopyramide is a medication used to treat obstructive hypertrophic cardiomyopathy. This study found that disopyramide inhibits multiple ion channels in cardiomyocytes, which may contribute to its effectiveness in reducing outflow gradients and preventing arrhythmias.
Paper Details　
Original Abstract of the Article :
Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion channels, lead...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978554/

データ提供：米国国立医学図書館（NLM）

Disopyramide for Obstructive Hypertrophic Cardiomyopathy

The field of [Cardiomyopathy] is constantly seeking new and effective treatments for this complex condition. This study investigated the effects of [Disopyramide], a [Class I Antiarrhythmic Drug], on [Obstructive Hypertrophic Cardiomyopathy]. The researchers combined [In Vitro Studies] using [Cardiomyocytes] with [Clinical Data] from [39 patients] treated with [Disopyramide]. They found that [Disopyramide] was effective and safe in reducing [Outflow Gradients] in patients with [Obstructive Hypertrophic Cardiomyopathy].

Understanding Disopyramide's Mechanism of Action

The study sheds light on the [Cellular and Molecular Mechanisms] of action of [Disopyramide]. The researchers found that [Disopyramide] inhibits multiple [Ion Channels], leading to a reduction in [Calcium Transients], [Contractile Force], and [Action Potential Duration]. These findings explain the effectiveness of [Disopyramide] in reducing [Outflow Gradients] while minimizing the risk of [Arrhythmias].

A Promising Treatment for Obstructive Hypertrophic Cardiomyopathy

This research offers a promising treatment option for [Obstructive Hypertrophic Cardiomyopathy]. It's like discovering a hidden spring in the desert, providing a source of relief for those struggling with this condition. The researchers' findings suggest that [Disopyramide] could be a safe and effective outpatient treatment for [Obstructive Hypertrophic Cardiomyopathy].

Dr.Camel's Conclusion

The study suggests that disopyramide is safe and effective in patients with obstructive hypertrophic cardiomyopathy. This could be a promising treatment option for patients with this condition.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

31998849

DOI: Digital Object Identifier

PMC6978554

Related Literature

Article Analysis
・Side Effects of disopyramide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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