Paper Details

  1. Home
  2. Paper Details

Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies.

Author: ChenChengjuan, ChenXiaoguang, FuJunmin, LaiFangfang, LiChuangjun, LiuKe, MaJie, ZangYingda, ZhangDongming, ZhangTiantai

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A series of novel triptolide/furoxans hybrids were synthesized as analogues of triptolide, a naturally derived compound with antiproliferative activity. Compound 33, one of the synthesized hybrids, exhibited both good antiproliferative activity and NO-releasing ability. It also showed significantly reduced acute toxicity compared to triptolide. Additionally, compound 33 inhibited melanoma growth at a low dose and exhibited strong anti-inflammatory activity *in vitro* and *in vivo*. These findings suggest that compound 33 could be a promising candidate for further research.
Paper Details　
Original Abstract of the Article :
A series of novel triptolide/furoxans hybrids were designed and synthesized as analogues of triptolide, which is a naturally derived compound isolated from the thunder god vine (Tripterygium wilfordii Hook. F). Some of these synthesized compounds exhibited antiproliferative activities in the nanomol...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ejmech.2020.112079

データ提供：米国国立医学図書館（NLM）

Nitric Oxide-Releasing Triptolide Derivatives: A New Weapon Against Cancer and Inflammation

The fight against cancer and inflammation is a constant struggle, and researchers are always seeking new and innovative ways to combat these debilitating conditions. This study explores a novel class of compounds, nitric oxide-releasing derivatives of triptolide, as potential antitumor and anti-inflammatory agents.

The study aims to design, synthesize, and evaluate the biological activity of these new compounds. The researchers synthesized a series of triptolide/furoxans hybrids and tested their effectiveness against cancer cells and their ability to reduce inflammation.

A Powerful Combination: A Desert Oasis of Hope

The study found that some of the newly synthesized compounds exhibited potent antiproliferative activity against cancer cells, effectively inhibiting their growth. One particular compound, 33, showed both strong antiproliferative activity and the ability to release nitric oxide. This is a significant finding, as it suggests that compound 33 could have both antitumor and anti-inflammatory properties.

Navigating the Desert of Cancer and Inflammation: A Guide for Patients

For individuals facing cancer or chronic inflammation, this study offers a glimmer of hope. While further research is needed, the study highlights the potential of these new compounds as promising therapeutic agents.

Dr. Camel's Conclusion

This study investigates the potential of nitric oxide-releasing triptolide derivatives as antitumor and anti-inflammatory agents. The research suggests that these new compounds may hold promise for treating cancer and inflammation, offering a new oasis of hope in the fight against these debilitating conditions.
Date :
  1. Date Completed 2020-12-04
  2. Date Revised 2020-12-14
Further Info :

Pubmed ID

32028140

DOI: Digital Object Identifier

10.1016/j.ejmech.2020.112079

Related Literature

Article Analysis
・Effective treatment of thunder god vine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.