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Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies.

Author: Chale-DzulJuan Bautista, Colín-LozanoBlanca, Estrada-SotoSamuel, Hernández-MartínezNorma Angélica, Hernández-NúñezEmanuel, Medina-FrancoJosé L, Moo-PucRosa, Navarrete-VázquezGabriel, Prieto-MartínezFernando Daniel, Rocha-GarduñoGenaro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study synthesized and evaluated carbamate derivatives of metronidazole and secnidazole, finding that some were more potent against Giardia duodenalis and Trichomonas vaginalis than their parent drugs.
Paper Details　
Original Abstract of the Article :
We prepared a series of 10 carbamates derivatives based on two common antiprotozoal drugs: metronidazole (<b>1</b>-<b>5</b>) and secnidazole (<b>6</b>-<b>10</b>). The compounds were tested in vitro against a set of two amitochondriate protozoa: <i>Giardia</i> <i>duodenalis</i> and <i>Trichomonas vag...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071106/

データ提供：米国国立医学図書館（NLM）

Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies

In the ongoing battle against parasitic infections, researchers are constantly exploring new therapeutic strategies. This study focuses on the synthesis and evaluation of a series of carbamate derivatives of metronidazole and secnidazole, two commonly used antiprotozoal drugs.

New Carbamates: A Journey Through the Desert of Antiprotozoal Therapy

The study synthesized and evaluated 10 carbamate derivatives of metronidazole and secnidazole, demonstrating their potent antiprotozoal activity against Giardia duodenalis and Trichomonas vaginalis. These derivatives exhibited significantly greater activity than their parent drugs, with metronidazole carbamate (1) showing particularly potent activity against both parasites. The study also conducted molecular dynamics simulations to understand the potential interactions of these compounds with key protein targets involved in the antiprotozoal activity of metronidazole and secnidazole.

Molecular Insights: Unveiling the Secrets of Drug Action

This study provides valuable insights into the structure-activity relationships of carbamate derivatives of metronidazole and secnidazole. The molecular dynamics simulations provide a deeper understanding of the potential mechanisms of action of these compounds, paving the way for the development of more targeted and effective antiprotozoal therapies.

Dr.Camel's Conclusion

This study highlights the potential of carbamate derivatives of metronidazole and secnidazole as promising new antiprotozoal agents. The findings suggest that these compounds exhibit significantly greater activity than their parent drugs, offering a potential advantage in treating parasitic infections. The molecular dynamics studies provide valuable insights into the potential mechanisms of action of these compounds, paving the way for the development of more effective and targeted therapies.
Date :
  1. Date Completed 2020-11-27
  2. Date Revised 2020-11-27
Further Info :

Pubmed ID

32059495

DOI: Digital Object Identifier

PMC7071106

Related Literature

Article Analysis
・Effects of secnidazole
SNS
PICO Info
in preparation
Languages

English

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