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Wastewater-derived antagonistic activities of G protein-coupled receptor-acting pharmaceuticals in river water.

Author: HanamotoSeiya, IharaMariko O, IharaMasaru, TanakaHiroaki, ZhangHan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study uses an in vitro assay to measure the biological activities of G protein-coupled receptor (GPCR)-acting pharmaceuticals in river water and wastewater treatment plant effluents. The results indicate that GPCR-acting pharmaceuticals are present in these environments, suggesting potential risks to aquatic species.
Paper Details　
Original Abstract of the Article :
Pharmaceuticals are widely detected in aquatic environments, and their potential risks to aquatic species are of concern because they are designed to be biologically active. Here, we used an in vitro assay, called the transforming growth factor α shedding assay, to measure the biological activities ...See full text at original site
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引用元：
https://doi.org/10.1002/jat.3952

データ提供：米国国立医学図書館（NLM）

Pharmaceuticals in River Water: A Hidden Threat to Aquatic Life

This study investigates the presence and potential effects of pharmaceuticals in river water. Researchers focused on G protein-coupled receptor (GPCR)-acting pharmaceuticals, which are designed to interact with specific receptors in the body. The study examined the biological activity of these pharmaceuticals in river water and effluent from wastewater treatment plants (WWTPs) using an in vitro assay.

Antagonistic Activities of Pharmaceuticals: A Potential Risk to Aquatic Environments

The study found that antagonistic activities against various receptors, including angiotensin, dopamine, adrenergic, acetylcholine, and histamine receptors, were present in river water, particularly downstream of WWTPs. These findings suggest that pharmaceuticals released into the environment can potentially disrupt the normal functioning of aquatic organisms.

The Need for Comprehensive Environmental Monitoring and Toxicity Testing

This study highlights the importance of comprehensive environmental monitoring and toxicity testing to assess the potential risks posed by pharmaceuticals in aquatic environments. Further research is crucial to understand the long-term effects of these chemicals on aquatic organisms and develop strategies for minimizing their impact on water quality.

Dr. Camel's Conclusion

Just as a camel navigates the desert, leaving its footprints in the sand, pharmaceuticals are leaving their mark on aquatic environments. This study serves as a reminder of the importance of responsible pharmaceutical use and the need to protect our precious water resources from potential contamination.

Date :
  1. Date Completed 2021-10-19
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

32077112

DOI: Digital Object Identifier

10.1002/jat.3952

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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