Activating Antibodies to The Calcium-sensing Receptor in Immunotherapy-induced Hypoparathyroidism.

Author: BrancatellaAlessandro, CetaniFilomena, KempE Helen, LatrofaFrancesco, LupiIsabella, MarcocciClaudio

Paper Details 
Original Abstract of the Article :
Immune checkpoint inhibitors (ICIs), such as programmed cell death protein-1 (PD-1), programmed cell death protein-ligand 1 (PD-L1), and cytotoxic T lymphocyte antigen-4 (CTLA-4) monoclonal antibodies, are approved for the treatment of some types of advanced cancer. Their main treatment-related side...See full text at original site
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引用元:
https://doi.org/10.1210/clinem/dgaa092

データ提供:米国国立医学図書館(NLM)

Immune Checkpoint Inhibitors: A Double-Edged Sword in Cancer Treatment

The field of [cancer immunotherapy] is making tremendous strides, but it's not without its challenges. This research examines a rare and unexpected side effect of [immune checkpoint inhibitors (ICIs)], specifically focusing on [hypoparathyroidism]. It's like discovering a hidden danger in a seemingly safe oasis, reminding us that even the most promising treatments can have unintended consequences.

Hypoparathyroidism: A Rare But Significant Side Effect of ICIs

The study highlights the potential for ICIs to induce hypoparathyroidism, a condition characterized by low levels of parathyroid hormone. While this side effect is extremely rare, it underscores the importance of vigilant monitoring for potential adverse events in patients undergoing ICI therapy. It's like finding a lone, venomous snake lurking in a beautiful desert garden, a reminder that even the most beautiful things can harbor danger.

Navigating the Landscape of Cancer Immunotherapy

The findings emphasize the need for ongoing research to better understand the complex interactions between ICIs and the immune system. This will help us develop strategies to minimize the risks of adverse events while maximizing the benefits of these innovative therapies. Just as a skilled traveler learns to adapt to the changing conditions of the desert, we must continually adapt our approaches to cancer treatment to ensure safety and efficacy.

Dr.Camel's Conclusion

This research underscores the need for ongoing vigilance in monitoring patients receiving ICI therapy for potential adverse events, including hypoparathyroidism. It's a reminder that even in the desert of cancer treatment, there can be hidden dangers that require careful navigation. The quest for effective cancer therapies continues, and it's crucial to balance progress with safety in our pursuit of better treatments.

Date :
  1. Date Completed 2021-02-03
  2. Date Revised 2021-02-03
Further Info :

Pubmed ID

32112105

DOI: Digital Object Identifier

10.1210/clinem/dgaa092

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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