A modified olanzapine-based anti-emetic regimen for the control of nausea and vomiting in patients receiving weekly cisplatin.

Author: ChristopherVasanth, DhanushkodiManikandan, GanesanPrasanth, GanesanTrivadi S, GanesharajahSelvaluxmy, MehraNikita, RadhakrishnanVenkatraman, SagarTenali Gnana

Paper Details 
Original Abstract of the Article :
Background There is limited data on specific antiemetic protocols for control of chemotherapy-induced nausea/vomiting (CINV) caused by weekly cisplatin regimens. Olanzapine is an active agent against CINV and may offer better control of nausea compared to aprepitant/fosaprepitant-based regimens. The...See full text at original site
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引用元:
https://doi.org/10.1007/s11096-020-00997-3

データ提供:米国国立医学図書館(NLM)

A Modified Olanzapine-Based Antiemetic Regimen for Weekly Cisplatin

This research focuses on a pressing issue in the field of cancer treatment, specifically how to effectively manage the nausea and vomiting side effects of chemotherapy. The study employed a modified regimen called 'mini-OPD', which involves a lower dose of olanzapine, a well-known antiemetic drug. The authors aimed to evaluate the effectiveness of this regimen in patients receiving weekly cisplatin for cervical cancer. They found that the 'mini-OPD' regimen was successful in significantly reducing nausea and vomiting without causing significant side effects. This discovery is a beacon of hope for patients undergoing chemotherapy, offering a less burdensome alternative to traditional antiemetic protocols.

A Promising Solution to a Common Problem

The 'mini-OPD' regimen achieved a complete response rate of 55%, meaning that over half of the patients experienced no emetic episodes and did not need any rescue medication. These results are like a cool oasis in the desert of chemotherapy side effects.

Minimizing Discomfort and Maximizing Wellbeing

This study is a testament to the fact that sometimes, less is more. The 'mini-OPD' regimen, with its lower dose of olanzapine, provides a balance between effective treatment and minimal discomfort. This allows patients to focus on their recovery without the overwhelming burden of nausea and vomiting. Such findings can have a positive impact on patients' quality of life, allowing them to better navigate the challenges of chemotherapy treatment.

Dr. Camel's Conclusion

This research is a valuable contribution to the field of cancer treatment, offering a promising and effective way to manage chemotherapy-induced nausea and vomiting. It is a reminder that even in the face of challenging medical conditions, innovative solutions and improved treatment options continue to emerge. Like a well-hydrated camel traversing the desert, patients undergoing weekly cisplatin chemotherapy can now benefit from a 'mini-OPD' regimen, allowing them to travel the road to recovery with less discomfort and a greater sense of wellbeing.
Date :
  1. Date Completed 2021-03-04
  2. Date Revised 2021-09-20
Further Info :

Pubmed ID

32152887

DOI: Digital Object Identifier

10.1007/s11096-020-00997-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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