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Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn's disease.

Author: AggarwalSaurabh, ClarkRyan, ColombelJean-Frederic, LeeWan-Ju, TopalogluOzlem, UngaroRyan C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review and meta-analysis of 47 studies found that early biologic treatment in Crohn's disease was associated with higher rates of clinical remission, lower relapse rates, and higher mucosal healing rates compared to late/conventional management.
Paper Details　
Original Abstract of the Article :
BACKGROUND: There is an increasing body of evidence showing that earlier use of biologics improves clinical outcomes in Crohn's disease (CD). AIM: To perform a systematic review and meta-analysis to assess the impact of early biologic use in the treatment of CD. METHODS: PubMed and Embase database...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32202328

データ提供：米国国立医学図書館（NLM）

Early Biologic Treatment for Crohn's Disease: A Beacon in the Desert

Crohn's disease, a chronic inflammatory bowel disease, can be a formidable adversary, often requiring a multifaceted approach to treatment. This research, like a well-equipped caravan venturing through a challenging desert, explores the efficacy and safety of early biologic treatment in patients with Crohn's disease.

Early Intervention: A Path to Improved Outcomes

The researchers, armed with the tools of a systematic review and meta-analysis, meticulously analyzed a vast array of studies, revealing compelling evidence for the benefits of early biologic treatment. The meta-analysis demonstrated that initiating biologics within two years of diagnosis or adopting a top-down treatment strategy, like strategically deploying resources in a desert expedition, resulted in significantly higher clinical remission rates, lower relapse rates, and improved mucosal healing compared to late or conventional management.

The Value of Early Intervention

This research underscores the importance of early intervention in Crohn's disease, highlighting the potential for biologics to significantly impact the course of the disease. Early treatment, like a timely oasis in the desert, can help mitigate the debilitating effects of Crohn's disease and improve the overall quality of life for patients.

Dr.Camel's Conclusion

This research, like a beacon guiding us through the desert of Crohn's disease treatment, sheds light on the benefits of early biologic intervention. The findings suggest that initiating biologics early in the disease course can significantly improve outcomes, leading to greater clinical remission, reduced relapses, and improved mucosal healing. This research is a testament to the importance of proactive and personalized approaches to managing chronic inflammatory bowel diseases, ensuring a more comfortable and fulfilling journey for patients.
Date :
  1. Date Completed 2020-10-02
  2. Date Revised 2021-05-02
Further Info :

Pubmed ID

32202328

DOI: Digital Object Identifier

NIHMS1573402

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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