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Timolol, dose response and duration of action.

Author: KaufmanH E, ZimmermanT J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Timolol maleate, a beta-adrenergic blocking agent, was effective in lowering intraocular pressure in patients with chronic open-angle glaucoma. The optimal dose was 0.5%. No significant side effects were observed.
Paper Details　
Original Abstract of the Article :
Timolol maleate, a beta-adrenergic blocking agent, was used in a study of 20 adult patients with chronic open-angle glaucoma. This single-dose study demonstrated a dose response for this drug using concentrations of 0.1%, 0.25%, 0.5%, and 1.0%. Timolol, 0.5%, appears to give the maximal ocular hypot...See full text at original site
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引用元：
https://doi.org/10.1001/archopht.1977.04450040071009

データ提供：米国国立医学図書館（NLM）

Timolol: A One-Dose Wonder for Glaucoma?

The world of ophthalmology is always on the lookout for new and effective treatments for glaucoma, a condition that affects the optic nerve and can lead to vision loss. This research dives into the effectiveness of timolol maleate, a beta-adrenergic blocking agent, in treating chronic open-angle glaucoma. The researchers used a single-dose study design, which is like testing a new water filtration system in a single desert oasis – a controlled environment for observing the effects. They administered different concentrations of timolol maleate to 20 adult patients. They discovered that timolol maleate, at a concentration of 0.5%, demonstrated a maximum ocular hypotensive effect, lowering eye pressure for at least 24 hours. Moreover, no local or systemic side effects were observed, making it a promising candidate for a safe and effective treatment option.

Timolol's Potential: A Glimpse into a Brighter Future

The study suggests that timolol maleate has the potential to be an effective and safe once-a-day topical agent for treating glaucoma. The results are significant because they provide evidence for a potential new treatment option that could improve the lives of many individuals suffering from this debilitating eye condition. Imagine a single dose of medication keeping your vision clear – a real oasis in the desert of glaucoma!

Living with Glaucoma: A Camel's Perspective

If you're living with glaucoma, it's important to consult with your ophthalmologist to discuss the best treatment options available. They can guide you through the desert of potential therapies and help you find the right approach for your specific needs. Remember, early detection and consistent treatment are key to maintaining vision. Just as a camel adapts to the harsh desert environment, you too can adapt and navigate the challenges of glaucoma with the right support.

Dr. Camel's Conclusion

Timolol maleate shows promise as a safe and effective treatment for glaucoma, offering a potential oasis in the desert of vision loss. It's encouraging to see research advancements that could improve the lives of those living with this condition. As with any medical treatment, consulting with your doctor is essential to determine the best course of action for your individual needs.

Date :
  1. Date Completed 1977-05-20
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

322649

DOI: Digital Object Identifier

10.1001/archopht.1977.04450040071009

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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