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Efficacy of Different Progestins in Women With Advanced Endometriosis Undergoing Controlled Ovarian Hyperstimulation for <i>in vitro</i> Fertilization-A Single-Center Non-inferiority Randomized Controlled Trial.

Author: ChaiWeiran, CongYanyan, FuYonglun, GaoHongyuan, GuoHaiyan, KuangYanping, LiBin, LiJianghui, LyuQifeng, MaMeng, MaoXiaoyan, ShenXi, WangYun, WuLing, ZhangWei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study compared the effects of three different progestins (medroxyprogesterone acetate, dydrogesterone, and progesterone) on ovarian response and pregnancy outcomes in women with advanced endometriosis undergoing IVF/ICSI. The study found that medroxyprogesterone acetate led to a higher number of oocytes retrieved compared to the other two groups. However, there were no significant differences among the three groups in fertilization and pregnancy outcomes. The study concluded that all three progestin protocols are equivalent in terms of pregnancy outcomes for women with advanced endometriosis and normal ovarian reserve.
Paper Details　
Original Abstract of the Article :
<b>Object:</b> Is it possible to use different progestins cotreatment with human menopausal gonadotrophin (hMG) in women with advanced endometriosis but normal ovulation during controlled ovarian hyperstimulation (COH) <i>in vitro</i> fertilization (IVF)? Whether different progestins treatments can...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103634/

データ提供：米国国立医学図書館（NLM）

Progestins for Advanced Endometriosis and IVF: Finding the Right Oasis in a Complex Desert

The journey to parenthood can be a challenging one, particularly for women with advanced endometriosis, a condition that can affect fertility. This study, like a skilled desert guide leading a caravan through treacherous terrain, explores the use of different progestins in combination with human menopausal gonadotropin (hMG) for women with advanced endometriosis undergoing in vitro fertilization (IVF).

Exploring the Possibilities: Comparing Different Progestins

The researchers conducted a randomized controlled trial comparing three different progestin treatments: medroxyprogesterone acetate, dydrogesterone, and progesterone. They aimed to determine whether these progestins could be an alternative choice for women with advanced endometriosis considering IVF/ICSI treatment. The results, like a refreshing oasis in the desert, offer some promising insights.

Navigating the Path to Parenthood: A Variety of Options

The study found that all three progestin treatments resulted in similar pregnancy outcomes for women with advanced endometriosis. This finding provides a variety of options for women navigating the complex journey of fertility treatment. The researchers acknowledge that further studies are needed to confirm these findings in other populations of women with endometriosis.

Dr. Camel's Conclusion

This study offers a glimmer of hope for women with advanced endometriosis seeking IVF/ICSI treatment. The findings suggest that different progestin protocols can be an alternative choice, providing greater flexibility in treatment options. However, further research is needed to confirm these findings and explore the potential benefits of these progestins for other populations of women with endometriosis.

Date :
  1. Date Completed 2021-02-16
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

32265834

DOI: Digital Object Identifier

PMC7103634

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

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