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Serious adverse effects of cannabidiol (CBD): a review of randomized controlled trials.

Author: CrippaJosé Alexandre S, Dos SantosRafael G, GuimarãesFrancisco S, HallakJaime E C, RochaJuliana Mendes, RossiGiordano Novak, ZuardiAntônio W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A review of randomized controlled trials (RCTs) using cannabidiol (CBD) found that serious adverse events (SAEs) are rare and mainly include elevated transaminases (related to concomitant valproate use), convulsion, sedation, lethargy, and upper respiratory tract infections (related to concomitant clobazam use). Epileptic patients should be monitored when using CBD concomitantly with these and other antiepileptic drugs.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Recent trials using cannabidiol (CBD) have shown that most acute and prolonged adverse effects of CBD are mild to moderate, with rare serious adverse effects (SAEs). This review focused on analyzing SAEs of CBD and their possible relation to drug-drug interactions. AREAS COVERED: We s...See full text at original site
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引用元：
https://doi.org/10.1080/17425255.2020.1754793

データ提供：米国国立医学図書館（NLM）

Serious Adverse Effects of Cannabidiol (CBD): A Camel's Journey Through the Desert of Medical Cannabis Research

The desert of medical cannabis research is a vast and complex landscape, with many questions to answer. This research delves into the potential serious adverse effects (SAEs) of cannabidiol (CBD), a non-psychoactive component of cannabis, as it gains increasing popularity as a therapeutic agent. The study examines SAEs reported in randomized controlled trials (RCTs) involving the administration of oral CBD, seeking to identify potential risks associated with its use.

The study found that SAEs related to CBD in RCTs were rare and mainly included elevated transaminases, convulsions, sedation, lethargy, and upper respiratory tract infections. The authors suggest that these SAEs may be related to drug-drug interactions, particularly when CBD is used concurrently with certain medications like valproate and clobazam.

Navigating the Desert of CBD: Finding the Right Path

The study underscores the importance of careful consideration of potential drug-drug interactions when CBD is used alongside other medications. This highlights the need for ongoing research to fully understand the potential risks and benefits of CBD, ensuring its safe and effective use.

The Camel's Perspective on CBD: A Journey Through the Desert of Medical Cannabis Research

As a camel, I have witnessed the therapeutic potential of various desert plants. This research sheds light on the potential risks and benefits of CBD, a plant-derived compound that has gained increasing attention for its therapeutic properties. While CBD may offer therapeutic potential, it's important to navigate this desert of research cautiously, considering potential interactions with other medications.

Dr. Camel's Conclusion

This research provides valuable insights into the potential serious adverse effects of CBD, highlighting the need for careful monitoring and consideration of potential drug-drug interactions. As we continue to explore the vast desert of medical cannabis research, it's crucial to prioritize safety and efficacy, ensuring that CBD is used appropriately and responsibly.

Date :
  1. Date Completed 2021-01-21
  2. Date Revised 2022-04-14
Further Info :

Pubmed ID

32271618

DOI: Digital Object Identifier

10.1080/17425255.2020.1754793

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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