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Benefits and Harms of Prescription Drugs and Supplements for Treatment of Clinical Alzheimer-Type Dementia.

Author: BrasureMichelle, ButlerMary, DesaiPriyanka J, FinkHoward A, ForteMary L, HemmyLaura S, LinskensEric J, MacDonaldRoderick, McCartenJ Riley, MillerMargaret A, NelsonVictoria A, NgWeiwen, OuelletteJeannine M, SheetsKerry M, SilvermanPombie C, TalleyKristine M C, TaylorBrent C, WiltTimothy J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Cholinesterase inhibitors and memantine showed slight benefits in reducing short-term cognitive decline in Alzheimer's disease patients, but their clinical significance remains unclear. Evidence on drug treatment of behavioral and psychological symptoms and supplement effects was insufficient.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Effects of drug treatment of clinical Alzheimer-type dementia (CATD) are uncertain. PURPOSE: To summarize evidence on the effects of prescription drugs and supplements for CATD treatment. DATA SOURCES: Electronic bibliographic databases (inception to November 2019), ClinicalTrials.gov ...See full text at original site
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引用元：
https://doi.org/10.7326/M19-3887

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Alzheimer's: A Quest for Effective Treatments

The search for effective treatments for [Alzheimer's disease] is like navigating a vast and unforgiving desert. This study delves into the complexities of [Alzheimer's disease] treatment, exploring the benefits and harms of various prescription drugs and supplements used to manage this challenging condition. The study meticulously reviewed a vast array of scientific literature, including [clinical trials], to assess the effectiveness of different medications and supplements in managing [Alzheimer's disease]. The researchers took a meticulous approach, evaluating the quality of evidence and considering the potential risks and benefits of different treatments. It’s like using a compass and map to navigate the desert, ensuring that we choose the right path in our quest for effective treatments.

Cholinesterase Inhibitors and Memantine: A Glimpse of Hope

The study found that [cholinesterase inhibitors] and [memantine] could slightly reduce short-term cognitive decline in patients with [Alzheimer's disease]. It's like finding a small oasis in the desert, offering some relief but not a complete solution. The study suggests that these medications may have some positive effects, but the evidence is not conclusive. The study also found that [cholinesterase inhibitors] were associated with an increased risk of side effects. This is like encountering a treacherous sandstorm in the desert – a reminder that even promising treatments can have potential downsides.

Protecting Your Mind: A Journey Through the Desert of Alzheimer's

The study highlights the importance of weighing the potential benefits and risks of different treatments for [Alzheimer's disease]. It’s like carefully navigating the desert, choosing the path that offers the best chance of survival. Further research is needed to develop more effective and safer treatments for this devastating disease. While the journey through the desert of [Alzheimer's disease] is long and arduous, this study offers a glimmer of hope for the future.

Dr.Camel's Conclusion

Despite the challenges, this study offers hope for the future of Alzheimer's treatment. While cholinesterase inhibitors and memantine may offer limited benefits, they are important tools in the fight against this devastating disease. Further research is essential to develop more effective and safer therapies for Alzheimer's, ultimately leading us to a new oasis of hope in the desert of this disease.

Date :
  1. Date Completed 2020-09-01
  2. Date Revised 2020-09-01
Further Info :

Pubmed ID

32340037

DOI: Digital Object Identifier

10.7326/M19-3887

Related Literature

Article Analysis
・Effective treatment of dementia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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