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In vitro synergistic effect of retapamulin with erythromycin and quinupristin against Enterococcus faecalis.

Author: MinYu-Hong, ParkByoungduck

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combinations of retapamulin with erythromycin and quinupristin exhibited in vitro synergistic activity against Enterococcus faecalis, including strains resistant to erythromycin. This finding suggests potential therapeutic benefits for treating skin and soft tissue infections caused by this bacterium.
Paper Details　
Original Abstract of the Article :
To find a therapeutic alternative for the treatment of skin and soft tissue infections, we evaluated the effects of combinations of retapamulin with macrolide, lincosamide, and streptogramin (MLS) antibiotics against Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecium, and Enterococc...See full text at original site
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引用元：
https://doi.org/10.1038/s41429-020-0312-7

データ提供：米国国立医学図書館（NLM）

Synergistic Effect of Retapamulin with Erythromycin and Quinupristin against *Enterococcus faecalis*

The battle against antibiotic resistance is a constant struggle, requiring innovative approaches to combat the emergence of drug-resistant bacteria. This study investigates the synergistic effect of retapamulin, a topical antibiotic, with erythromycin and quinupristin against *Enterococcus faecalis*, a common cause of skin and soft tissue infections. It's like a desert fortress, employing a multi-pronged attack to overcome a formidable foe.

A Powerful Combination Against *E. faecalis*

The study reveals that combinations of retapamulin with erythromycin and quinupristin exhibit synergistic activity against *E. faecalis*, even against strains with high-level erythromycin resistance. This is like a desert caravan, employing a team of camels to navigate the treacherous terrain of antibiotic resistance. The study suggests that these combinations could be a promising new strategy for treating *E. faecalis* infections, particularly those resistant to conventional therapies.

New Hope for Treating Antibiotic-Resistant Infections

This research offers a glimmer of hope in the fight against antibiotic resistance. The synergistic effect of retapamulin with erythromycin and quinupristin provides a potential new weapon in the arsenal of antimicrobial agents. It's like discovering a hidden oasis in the desert of antibiotic resistance, offering a new source of protection against these formidable foes.

Dr.Camel's Conclusion

This study provides valuable insights into the potential of synergistic drug combinations to overcome antibiotic resistance. It offers a potential new treatment strategy for *E. faecalis* infections, particularly those resistant to conventional therapies. This research highlights the importance of continued exploration of drug interactions and the potential for synergistic combinations to address the growing threat of antibiotic resistance.

Date :
  1. Date Completed 2020-12-24
  2. Date Revised 2021-03-24
Further Info :

Pubmed ID

32346089

DOI: Digital Object Identifier

10.1038/s41429-020-0312-7

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in preparation
Languages

English

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