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Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT.

Author: ArdenNigel, BeardDavid J, CampbellHelen, CampbellMarion K, CarrAndrew, CookJonathan A, DaviesLoretta J, FitzpatrickRay, HudsonJemma, KentSeamus, LealJose, MacLennanGraeme, MurrayDavid, PriceAndrew

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Partial knee replacement and total knee replacement were equally effective in treating late-stage medial compartment knee osteoarthritis, with similar clinical outcomes, reoperation rates, and complication rates. Partial knee replacement was found to be more cost-effective than total knee replacement.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence to guide selection. OBJECTIVE: To assess the clinical effectiveness and cos...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232134/

データ提供：米国国立医学図書館（NLM）

Total vs. Partial Knee Replacement for Medial Compartment Knee Osteoarthritis

This randomized controlled trial (RCT) investigates the clinical effectiveness and cost-effectiveness of partial knee replacement (PKR) compared to total knee replacement (TKR) for patients with medial compartment knee osteoarthritis. The study aimed to provide evidence-based guidance for surgical decision-making in this patient population. The study enrolled a large number of participants and followed them for a five-year period, allowing for a comprehensive assessment of long-term outcomes.

Comparable Outcomes for Partial and Total Knee Replacement

The study's findings demonstrate that both PKR and TKR are effective surgical interventions for medial compartment knee osteoarthritis, offering comparable clinical outcomes in terms of pain relief, functional improvement, and patient satisfaction. The study found no significant differences in reoperation or complication rates between the two approaches. Furthermore, PKR emerged as the more cost-effective option at five years.

Making Informed Decisions About Knee Replacement: A Patient-Centered Approach

The study emphasizes the importance of shared decision-making between patients and surgeons when considering knee replacement options. The research provides valuable evidence to support informed discussions about the potential benefits and risks of both PKR and TKR. Patients should be fully informed about the potential outcomes, recovery timelines, and long-term implications of each approach.

Dr.Camel's Conclusion

Like a camel choosing the best path across a vast desert, patients with medial compartment knee osteoarthritis face a significant decision when considering knee replacement. This RCT provides valuable insights into the relative benefits and costs of both PKR and TKR, empowering patients and surgeons to make informed decisions based on individual needs and preferences. The study's findings underscore the importance of a collaborative approach to surgical decision-making, ensuring the best possible outcomes for patients.

Date :
  1. Date Completed 2021-09-13
  2. Date Revised 2021-09-13
Further Info :

Pubmed ID

32369436

DOI: Digital Object Identifier

PMC7232134

Related Literature

Article Analysis
・Effective treatment of knee replacement
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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