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Topical tacalcitol as neoadjuvant for photodynamic therapy of acral actinic keratoses: An intra-patient randomized study.

Author: BorgiaFrancesco, CannavòSerafinella Patrizia, CatalanoFabio, CoppolaMarialorena, GiuffridaRoberta, RisoGabriella

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This prospective, randomized, intra-individual study compared topical tacalcitol pretreatment followed by 5-ALA-PDT with conventional 5-ALA-PDT for acral actinic keratoses (AKs). The study aims to evaluate the efficacy and safety of these treatment approaches for AKs on the upper extremities.
Paper Details　
Original Abstract of the Article :
photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is a well described and widely practiced treatment for actinic keratoses (AKs) on the head and face. Less is known about its use for AKs on upper extremities, which can be challenging for the dermatologist. The aim of our study was ...See full text at original site
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引用元：
https://doi.org/10.1016/j.pdpdt.2020.101803

データ提供：米国国立医学図書館（NLM）

Topical Tacalcitol for Photodynamic Therapy of Acral Actinic Keratoses

Imagine a traveler facing a harsh desert sun, battling the effects of prolonged exposure. This research investigates the use of topical tacalcitol as a neoadjuvant for photodynamic therapy (PDT) of acral actinic keratoses (AKs), common skin lesions often found on sun-exposed areas. The study compares the combination of topical tacalcitol with PDT to conventional PDT, exploring its potential to enhance treatment effectiveness and minimize side effects.

Topical Tacalcitol: A Potential Booster for PDT

This research highlights the potential of topical tacalcitol as a neoadjuvant for PDT of acral AKs, suggesting that it could improve treatment outcomes and potentially minimize side effects. It's like discovering a hidden oasis in the desert, providing a source of strength and resilience for the traveler battling the harsh sun's rays. The study emphasizes the need for further research to confirm its effectiveness and optimize treatment strategies.

Health Implications and Applications

For individuals dealing with acral AKs, finding effective and safe treatment options is crucial for managing these common skin lesions. This research underscores the importance of exploring innovative treatment approaches and optimizing existing therapies to ensure optimal patient outcomes. It's like equipping a traveler with a protective sunscreen and hat to navigate a desert, ensuring a safe and healthy journey.

Dr.Camel's Conclusion

This research provides valuable insights into the potential of topical tacalcitol as a neoadjuvant for PDT of acral AKs, suggesting a potential path towards improved treatment outcomes and minimized side effects. It's like discovering a hidden oasis in the desert, offering a source of comfort and strength for those seeking effective treatment for these common skin lesions. Further research is needed to confirm its effectiveness and optimize treatment strategies.

Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

32389738

DOI: Digital Object Identifier

10.1016/j.pdpdt.2020.101803

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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