Side Effects of aminolevulinic acid topical: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Main Research Findings

5-ALA topical is a photosensitizer used in photodynamic therapy (PDT). PDT has been shown to be effective in treating a variety of skin conditions, such as skin cancer, common warts, and psoriasis. 1 , 2 , 13 , 15 , 3 , 16 , 10 , 19 , 4 , 6 , 12 , 14 , 5 , 20 , 8 , 7 , 18 , 11 These studies have shown that 5-ALA topical is often an effective and safe treatment.

Reasons for Side Effects

The side effects of 5-ALA topical are related to the fact that it is a photosensitizer, which means that it reacts with light and can potentially damage tissue. 1

Common Side Effects

Pain

You may experience pain or a burning sensation at the site where the 5-ALA topical is applied. 14 , 11 These symptoms usually go away within a few hours after treatment.

Redness

The area where the 5-ALA topical is applied may become red. 14 , 10 These symptoms usually go away within a few days after treatment.

Swelling

The area where the 5-ALA topical is applied may swell. 14 These symptoms usually go away within a few days after treatment.

Dryness

The area where the 5-ALA topical is applied may become dry. 14 , 20 These symptoms usually go away within a few days after treatment.

Itching

The area where the 5-ALA topical is applied may become itchy. 14 , 20 These symptoms usually go away within a few days after treatment.

Blisters

You may develop blisters at the site where the 5-ALA topical is applied. 14 , 20 These symptoms usually go away within a few days after treatment.

Pigmentation

You may experience pigmentation at the site where the 5-ALA topical is applied. 20 These symptoms usually go away within a few months after treatment.

Scarring

You may develop scarring at the site where the 5-ALA topical is applied. 10 These symptoms usually go away within a few months after treatment.

Side Effects Management

Pain

You can take steps to reduce pain, such as cooling the area or taking pain relievers. 11

Redness

You can take steps to reduce redness, such as cooling the area.

Swelling

You can take steps to reduce swelling, such as cooling the area.

Dryness

You can take steps to reduce dryness, such as using a moisturizer.

Itching

You can take steps to reduce itching, such as applying a steroid cream.

Blisters

You can take steps to reduce blisters, such as cooling the area.

Pigmentation

You can take steps to reduce pigmentation, such as using a skin-lightening agent.

Scarring

You can take steps to reduce scarring, such as undergoing laser treatment.

Comparison of Studies

Similarities

Many studies have shown that 5-ALA topical is an effective and safe treatment. However, reports of side effects vary from study to study.

Differences

Reports of side effects of 5-ALA topical vary from study to study. This is likely due to differences in research methodology, patient characteristics, and treatment regimens.

Points to Note in Real Life Application

While 5-ALA topical is often an effective and safe treatment, it is important to remember that there is a risk of side effects. Before undergoing treatment, it is important to talk to your doctor and understand the risks and benefits of treatment.

Limitations of Current Research

Further research is needed on the long-term safety and efficacy of 5-ALA topical.

Future Research Directions

Further research is needed to evaluate the long-term safety and efficacy of 5-ALA topical. It is also important to develop methods to reduce side effects of 5-ALA topical.

Conclusion

5-ALA topical is often an effective and safe treatment, but it is important to remember that there is a risk of side effects. Before undergoing treatment, it is important to talk to your doctor and understand the risks and benefits of treatment. Further research is needed to evaluate the long-term safety and efficacy of 5-ALA topical. It is also important to develop methods to reduce side effects of 5-ALA topical.

Literature analysis of 20 papers
Positive Content
20
Neutral Content
0
Negative Content
0
Article Type
2
0
1
3
19
6.

Comparative study of topical 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) and surgery for the treatment of high-grade vaginal intraepithelial neoplasia.

Author: ZhangYingcui, SuYuehui, TangYujie, QinLihong, ShenYan, WangBingjie, ZhouMengjiao, ZhouYingying, CaoLili, ZhangTing, ZhangMengzhen

HPV clearance
VAIN treatment
Recurrent lesions

5-aminolevulinic acid photodynamic therapy (ALA-PDT) shows similar efficacy and less side effects compared to local surgical excision for high-grade vaginal intraepithelial neoplasia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

The Effect of Photodynamic Therapy on Oral-Premalignant Lesions: A Systematic Review.

Author: ChoudharyRuchika, ReddySujatha S, NagiRavleen, NagarajuRakesh, KunjumonSreekanth P, SenRitu

oral premalignant lesion treatment

Photodynamic therapy (PDT) is a non-invasive treatment option for oral premalignant lesions. This study investigates its effectiveness and potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Lipid Nanocarriers for Hyperproliferative Skin Diseases.

Author: SoutoEliana B, de SouzaAna L R, Dos SantosFernanda K, Sanchez-LopezElena, CanoAmanda, ZielińskaAleksandra, StaszewskiRafał, KarczewskiJacek, GremiãoMaria P D, ChorilliMarlus

HSD treatment
Increased efficacy
Reduced side effects

Hyperproliferative skin diseases (HSD) are a group of skin conditions requiring anti-proliferative therapies. Many anti-proliferative agents, including 5-fluorouracil, imiquimod, and methotrexate, have low aqueous solubility, limiting their skin permeation. This manuscript discusses the advantages of using lipid nanoparticles and liposomes as drug delivery systems for HSD treatment. These nanocarriers offer improved drug delivery, enhanced efficacy, and reduced side effects compared to conventional topical therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Bimodal photodynamic therapy for treatment of a 91-year-old patient with locally advanced cutaneous basal cell carcinoma and postoperative scar management.

Author: LiaoCaihe, ShiLei, WangDixin, WangXiuli

laBCC treatment
Hypertrophic scar
Pain

Bimodal photodynamic therapy (PDT), combining HiPorfin-PDT and modified topical ALA-PDT, was successful in treating a 91-year-old patient with locally advanced basal cell carcinoma (laBCC).

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Three-step irradiance schedule versus two-step irradiance schedule for pain control during topical 5-aminolevulinic acid-photodynamic therapy of facial acne in Chinese patients: A prospective randomized comparative study.

Author: WuHai-En, LiuYong-Bin, CuiLiang, XuGui-Juan, SunXiao-Dong

Pain relief

A new three-step irradiance schedule derived from the 'peak-end rule' was found to be more effective in relieving pain during 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for acne than a two-step schedule. The three-step schedule significantly reduced pain levels without affecting the effective rate.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

The place of 5-aminolaevulinic acid-photodynamic therapy in the treatment landscape of urethral warts: A systematic review.

Author: KechichianElio, HelouElie, SarkisJulien, HayekClaude, LabakiChris, NemrElie, TombRoland

Urethral wart clearance
Adverse events

This systematic review of 26 articles found that 5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) was the most effective treatment for urethral condylomas in terms of clearance and recurrence rate, with a higher risk of adverse events compared to laser therapy or topical treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

5-ALA-photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus.

Author: ZhangFenghua, LiDaoyun, ShiLijuan, GuYijia, XuYun

Treats vulvar leukoplakia

The clinical efficacy and safety of photodynamic therapy (PDT) in combination with 5-aminoketovaleric acid (ALA) for the treatment of vulvar leukoplakia were investigated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Topical tacalcitol as neoadjuvant for photodynamic therapy of acral actinic keratoses: An intra-patient randomized study.

Author: BorgiaFrancesco, RisoGabriella, CatalanoFabio, CoppolaMarialorena, GiuffridaRoberta, CannavòSerafinella Patrizia

Actinic keratosis treatment

This prospective, randomized, intra-individual study compared topical tacalcitol pretreatment followed by 5-ALA-PDT with conventional 5-ALA-PDT for acral actinic keratoses (AKs). The study aims to evaluate the efficacy and safety of these treatment approaches for AKs on the upper extremities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Emerging noninvasive treatments of nonmelanoma skin cancers.

Author: TongdeeEmily, PsomadakisCorinna Eleni, PakaPavan, MarghoobNadeem, MarkowitzOrit

NMSC treatment
Side effects

Nonmelanoma skin cancer is the most common type of skin cancer, and its incidence is increasing. New and potential treatments include topical sonidegib, cemiplimab, taladegib, posaconazole, radiation therapy, and laser therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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