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A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity.
Author: BayirYasin, CadirciElif, HaliciZekai, KoseDuygu, SelliJale, UganRustem Anil, UnHarun
Original Abstract of the Article :
Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ejphar.2020.173168
データ提供:米国国立医学図書館(NLM)
Aprepitant: A Potential Oasis in the Desert of Cisplatin Toxicity
The study explores the potential benefits of Aprepitant, a medication primarily used for nausea and vomiting associated with chemotherapy, in mitigating the harmful side effects of Cisplatin, a powerful cancer treatment. The researchers employed animal models to investigate the protective effects of Aprepitant on Cisplatin-induced nephrotoxicity and hepatotoxicity. This research, much like navigating a treacherous desert, aims to find ways to alleviate the harmful effects of chemotherapy.
Aprepitant: A Shining Beacon in the Desert
The study found that Aprepitant effectively normalized serum enzyme levels, reduced oxidative stress, and countered the inflammatory response triggered by Cisplatin in the kidneys and liver of rats. The results, like finding a freshwater spring in the desert, suggest that Aprepitant might be a valuable tool for protecting against the toxic side effects of Cisplatin. This discovery could significantly enhance the quality of life for cancer patients undergoing chemotherapy.
A Hopeful Glimpse in the Treatment of Cancer
This study opens a promising avenue for alleviating the side effects of cancer treatment. The potential of Aprepitant to protect against Cisplatin-induced nephrotoxicity and hepatotoxicity offers hope for better outcomes and improved quality of life for cancer patients. As we continue our research, we may discover even more ways to navigate the challenging landscape of cancer treatment and provide patients with the best possible care.
Dr.Camel's Conclusion
This research, like a cool breeze in the desert, brings hope to patients undergoing Cisplatin therapy. Aprepitant's potential to mitigate the side effects of this powerful treatment offers a beacon of hope in the fight against cancer.
Date :
- Date Completed 2021-03-24
- Date Revised 2021-03-24
Further Info :
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