Paper Details 
Original Abstract of the Article :
Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejphar.2020.173168

データ提供:米国国立医学図書館(NLM)

Aprepitant: A Potential Oasis in the Desert of Cisplatin Toxicity

The study explores the potential benefits of Aprepitant, a medication primarily used for nausea and vomiting associated with chemotherapy, in mitigating the harmful side effects of Cisplatin, a powerful cancer treatment. The researchers employed animal models to investigate the protective effects of Aprepitant on Cisplatin-induced nephrotoxicity and hepatotoxicity. This research, much like navigating a treacherous desert, aims to find ways to alleviate the harmful effects of chemotherapy.

Aprepitant: A Shining Beacon in the Desert

The study found that Aprepitant effectively normalized serum enzyme levels, reduced oxidative stress, and countered the inflammatory response triggered by Cisplatin in the kidneys and liver of rats. The results, like finding a freshwater spring in the desert, suggest that Aprepitant might be a valuable tool for protecting against the toxic side effects of Cisplatin. This discovery could significantly enhance the quality of life for cancer patients undergoing chemotherapy.

A Hopeful Glimpse in the Treatment of Cancer

This study opens a promising avenue for alleviating the side effects of cancer treatment. The potential of Aprepitant to protect against Cisplatin-induced nephrotoxicity and hepatotoxicity offers hope for better outcomes and improved quality of life for cancer patients. As we continue our research, we may discover even more ways to navigate the challenging landscape of cancer treatment and provide patients with the best possible care.

Dr.Camel's Conclusion

This research, like a cool breeze in the desert, brings hope to patients undergoing Cisplatin therapy. Aprepitant's potential to mitigate the side effects of this powerful treatment offers a beacon of hope in the fight against cancer.

Date :
  1. Date Completed 2021-03-24
  2. Date Revised 2021-03-24
Further Info :

Pubmed ID

32423870

DOI: Digital Object Identifier

10.1016/j.ejphar.2020.173168

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SNS
PICO Info
in preparation
Languages

English

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