T Cell Delivery of Nanoparticles-Bound Anti-CD20 Monoclonal Antibody: Successful B Cell Depletion in the Spinal Cord during Experimental Autoimmune Encephalomyelitis.

Author: AmorielloRoberta, BaldiGiovanni, BalleriniClara, BonechiElena, CappielloLaura, CarnascialiAlberto, D'EliosMario Milco, DoumettSaer, MazzoniAlessio, RavagliCostanza

Paper Details 
Original Abstract of the Article :
We developed a nanotechnology based-cell mediated drug delivery system by loading myelin antigen-specific T cells with nanoparticles bound to anti-CD20 monoclonal antibody. Anti-CD20 antibody is a current treatment (ocrelizumab) for multiple sclerosis (MS), a chronic, inflammatory and autoimmune dis...See full text at original site
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引用元:
https://doi.org/10.1007/s11481-020-09931-w

データ提供:米国国立医学図書館(NLM)

Nanotechnology: A New Frontier in Multiple Sclerosis Treatment

Multiple sclerosis (MS) is like a desert storm, relentlessly attacking the central nervous system. This research explores a novel nanotechnology-based approach to delivering anti-CD20 monoclonal antibody, a promising treatment for MS, directly to the spinal cord. The researchers are like innovative engineers, designing targeted therapies to combat this debilitating disease.

A Targeted Approach: Reaching the Heart of the Storm

This research is like building a bridge over a raging desert river, using nanoparticles to deliver the antibody to its intended target. By loading myelin antigen-specific T cells with nanoparticles containing the antibody, researchers can effectively deliver the treatment directly to the spinal cord, where inflammation is most severe. This strategy is like navigating a sandstorm with a GPS, ensuring the treatment reaches its destination with precision.

Hope for the Future: A New Era for MS Treatment

This study's findings offer a glimmer of hope for MS patients. It's like finding a hidden oasis in the desert, providing a new and effective treatment option. The research demonstrates that this targeted delivery system effectively reduces B cell populations in both the spleen and the brain, offering potential for improved treatment outcomes.

Dr. Camel's Conclusion

This research is like a journey through the desert of MS research, revealing the potential of nanotechnology to revolutionize treatment approaches. This innovative strategy, like a beacon of light in the storm, offers hope for a brighter future for MS patients.

Date :
  1. Date Completed 2021-12-06
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

32514635

DOI: Digital Object Identifier

10.1007/s11481-020-09931-w

Related Literature

SNS
PICO Info
in preparation
Languages

English

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