Keratinocyte growth factor ameliorates mycophenolate mofetil-induced intestinal barrier disruption in mice.

Author: HeWeifeng, HouJingming, HuWengang, HuangChibing, LiYang, LiangGuangping, LiuYun, SongYajun, WangXu, XiaoYa

Paper Details 
Original Abstract of the Article :
Although mycophenolate mofetil-induced (MMF) effectively improves long-term graft survival, the gastrointestinal (GI) side effects due to MMF-induced GI barrier damage limit its use in clinic. Keratinocyte growth factor (KGF) plays a crucial role in the intestinal protection and repair process. This...See full text at original site
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引用元:
https://doi.org/10.1016/j.molimm.2020.04.012

データ提供:米国国立医学図書館(NLM)

Protecting the Intestinal Barrier from Mycophenolate Mofetil-Induced Damage

This study delves into the [gastrointestinal health] landscape, exploring the potential of keratinocyte growth factor (KGF) to protect the intestinal barrier from damage induced by mycophenolate mofetil (MMF), a commonly used immunosuppressant drug. The authors, like skilled engineers reinforcing a fragile structure, investigated the protective effects of KGF on the intestinal mucosa. This research, like a well-placed oasis in the desert, reveals the potential of KGF to mitigate the gastrointestinal side effects associated with MMF, expanding the therapeutic options for patients requiring immunosuppression.

The Importance of Gut Health in Immunosuppression

This study underscores the importance of maintaining gut health in patients receiving immunosuppression. The findings highlight the delicate balance between suppressing the immune system to prevent organ rejection and minimizing the side effects of immunosuppressant drugs on the gastrointestinal tract. This research, like a compass guiding healthcare providers through the complexities of immunosuppression, emphasizes the need for strategies to protect the gut barrier and minimize the risk of complications.

The Potential of Keratinocyte Growth Factor in Gastrointestinal Protection

This study reveals the potential of KGF as a valuable tool for protecting the intestinal barrier from damage induced by immunosuppressant drugs. The findings suggest that KGF, like a desert plant thriving in harsh conditions, can promote intestinal repair and maintain the integrity of the gut mucosa. This research paves the way for further exploration of KGF as a therapeutic agent for protecting the gastrointestinal tract in patients undergoing immunosuppressive therapy.

Dr.Camel's Conclusion

This research, like a camel caravan traversing a vast desert, reveals the potential of keratinocyte growth factor (KGF) to protect the intestinal barrier from damage induced by mycophenolate mofetil (MMF). The study highlights the importance of maintaining gut health during immunosuppression and underscores the potential of KGF as a therapeutic agent for mitigating the gastrointestinal side effects of MMF. This research encourages further exploration of strategies to protect the gut barrier and improve the overall well-being of patients undergoing immunosuppressive therapy.
Date :
  1. Date Completed 2020-09-04
  2. Date Revised 2020-09-04
Further Info :

Pubmed ID

32534355

DOI: Digital Object Identifier

10.1016/j.molimm.2020.04.012

Related Literature

SNS
PICO Info
in preparation
Languages

English

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