Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65 Years or Older.

Author: CheyWilliam D, FranklinHoward, MeneesStacy B

Paper Details 
Original Abstract of the Article :
Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) are common functional gastrointestinal disorders. The prevalence of constipation-related issues tends to increase with age. This analysis pooled data from Phase III trials in CIC and IBS-C to assess the safe...See full text at original site
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引用元:
https://doi.org/10.1016/j.clinthera.2020.05.012

データ提供:米国国立医学図書館(NLM)

Treating Constipation in Older Adults: Plecanatide's Potential

In the vast expanse of medical knowledge, the complexities of constipation are a challenge we must face. This research, like a camel navigating a challenging terrain, investigates the efficacy and safety of plecanatide, a novel drug, in treating chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in patients aged 65 years or older. The researchers, with the wisdom of a seasoned traveler, sought to understand how this drug might benefit older adults who struggle with constipation.

The study pooled data from Phase III trials in CIC and IBS-C, specifically focusing on participants aged 65 years or older. The researchers meticulously analyzed data on patient outcomes, including improvements in bowel function, overall symptom relief, and safety profiles. The study sought to determine the effectiveness and safety of plecanatide in this specific population, addressing the unique needs of older adults.

Plecanatide: A Promising Option for Older Adults with Constipation

The pooled data from Phase III trials demonstrated that plecanatide was effective in improving bowel function and reducing constipation symptoms in patients aged 65 years or older. The drug was found to be well-tolerated in this population, suggesting that it could be a valuable treatment option for older adults struggling with CIC or IBS-C. This research provides valuable insights into the potential benefits of plecanatide in addressing constipation in this often-overlooked population.

The Importance of Addressing Constipation in Older Adults

This research highlights the importance of addressing constipation in older adults, a condition that can significantly impact their quality of life. The findings suggest that plecanatide could be a valuable treatment option for this population, offering relief from constipation symptoms and improving overall well-being. This research encourages further investigation into the use of plecanatide and other pharmacological interventions to address constipation in older adults.

Dr. Camel's Conclusion

This research offers hope for individuals aged 65 years or older who struggle with constipation. The findings suggest that plecanatide could be a safe and effective treatment option for this population, providing relief from constipation symptoms and improving quality of life. This research encourages further exploration of plecanatide and other treatments to address the unique challenges of constipation in older adults, ensuring that this important population receives the appropriate care they need.

Date :
  1. Date Completed 2021-02-08
  2. Date Revised 2021-02-08
Further Info :

Pubmed ID

32660770

DOI: Digital Object Identifier

10.1016/j.clinthera.2020.05.012

Related Literature

SNS
PICO Info
in preparation
Languages

English

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