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Minocycline augmentation in older adults with persistent depression: an open label proof of concept study.

Author: AlexopoulosGeorge S, AvariJimmy N, KanellopoulosDora, OberlinLauren, SolomonovNili

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This pilot study investigated the efficacy of minocycline augmentation in older adults with major depression who failed to achieve remission after adequate antidepressant treatment. The study found that 31% of patients achieved remission after 8 weeks of minocycline augmentation. While further research is needed, the results suggest potential benefit of minocycline augmentation for treating depression in older adults who have not responded well to conventional treatments.
Paper Details　
Original Abstract of the Article :
Less than 40% of depressed older adults treated with an antidepressant achieve remission. Incomplete response to treatment is common. Current augmentation strategies have limited efficacy, and many have side effects that restrict their utilization in older adults. We conducted the first open pilot t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32690123

データ提供：米国国立医学図書館（NLM）

Finding a Oasis in the Desert of Depression

Depression, a debilitating condition that can cast a long shadow over life, is a common challenge, especially among older adults. While antidepressants are often used, they don't always provide complete relief, leaving many feeling like they're stuck in a dry and desolate desert. This open pilot trial explored the potential of minocycline, a drug typically used for bacterial infections, as an augmentation strategy for older adults with persistent depression.

Minocycline: A Glimmer of Hope in the Desert

The results showed that minocycline augmentation led to remission in 31% of the participants after eight weeks. This suggests that minocycline could offer a potential oasis in the desert of persistent depression for some individuals. However, it's important to note that this was a small study, and larger placebo-controlled trials are needed to confirm these findings. It's like discovering a promising spring in the desert, but further exploration is needed to determine its true potential.

Life in the Desert: What to Consider

This research offers a glimmer of hope for older adults struggling with persistent depression. While minocycline may not be a cure-all, it could be a valuable tool for some individuals. It's essential to discuss all treatment options with a healthcare professional and to explore different approaches until finding the right path out of the desert of depression.

Dr. Camel's Conclusion

This pilot trial is a step in the right direction, offering a potential new oasis in the desert of persistent depression. It's a reminder that even in the face of complex conditions, there is always hope for finding effective treatments. Further research is crucial to better understand the potential benefits and limitations of minocycline augmentation in this context. It's a testament to the ongoing pursuit of solutions to this challenging and often isolating condition.

Date :
  1. Date Completed 2021-06-24
  2. Date Revised 2021-08-10
Further Info :

Pubmed ID

32690123

DOI: Digital Object Identifier

NIHMS1700883

Related Literature

Article Analysis
・Side Effects of minocycline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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