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Bone density, microarchitecture and tissue quality after 1 year of treatment with dolutegravir/abacavir/lamivudine.
Author: Arrieta-AldeaItziar, BrownTodd T, BujosaDaniel, Díez-PérezAdolfo, García-GiraltNatalia, González-MenaAlicia, Güerri-FernándezRobert, KnobelHernando, Lerma-ChippirrazElisabeth, Pineda-MoncusiMarta, Soldado-FolgadoJade, Trenchs-RodríguezMarta, Villar-GarcíaJudit
Original Abstract of the Article :
BACKGROUND: Bone mineral density (BMD) decreases with ART initiation with a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC)-based ART initiation on bone health parameters is not clear. OBJECTI...See full text at original site
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引用元:
https://doi.org/10.1093/jac/dkaa254
データ提供:米国国立医学図書館(NLM)
Dolutegravir/Abacavir/Lamivudine: Navigating the Desert of HIV Treatment
HIV treatment, like a long and arduous desert journey, requires a careful balance of effectiveness and safety. This research explores the impact of dolutegravir/abacavir/lamivudine (DTG/ABC/3TC)-based therapy on bone health, a critical aspect of long-term HIV management. It seeks to find a path that minimizes potential side effects while maintaining optimal antiviral control.
Bone Health in the Desert of HIV Treatment
This study, like a desert traveler observing the impact of changing weather patterns on the landscape, investigates the impact of DTG/ABC/3TC therapy on bone density, microarchitecture, and tissue quality. The researchers found that while bone mineral density decreased, bone tissue quality improved after 48 weeks of treatment. This finding, like a surprising oasis amidst a dry landscape, suggests that while DTG/ABC/3TC therapy may have some impact on bone density, it may also enhance the structural properties of bone.
A Balanced Approach to HIV Treatment
This study emphasizes the need for a comprehensive assessment of bone health in patients receiving DTG/ABC/3TC therapy. While the drug regimen shows promise in controlling HIV, careful monitoring of bone health is crucial for ensuring long-term well-being. This research highlights the need for a balanced approach to HIV treatment, considering both viral control and the potential impact on overall health.
Dr.Camel's Conclusion
This research provides valuable insights into the impact of DTG/ABC/3TC therapy on bone health. While the study suggests that the drug regimen may have some impact on bone density, it also highlights potential benefits in terms of bone tissue quality. This research underscores the importance of a holistic approach to HIV treatment, considering both viral control and the long-term health of patients.
Date :
- Date Completed 2021-06-24
- Date Revised 2021-06-24
Further Info :
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