Effective treatment of bone density: A Synthesis of Findings from 29 Studies

  1. Home
  2. Effective treatment of bone density
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of bone density: A Synthesis of Findings from 29 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of bone density: A Synthesis of Findings from 29 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Bone density naturally declines with age, increasing the risk of fractures. Postmenopausal women are especially vulnerable to bone loss, making osteoporosis prevention and treatment crucial. Various therapies have been developed, and numerous studies have been conducted to assess their effects on bone density and efficacy.

For instance, a study 17 evaluated the effectiveness of osteoporosis treatments using dual-energy X-ray absorptiometry (DXA) scans. It revealed that patients receiving alendronate/cholecalciferol experienced a significant improvement in femoral neck bone density compared to other medications.

Another study 18 compared the long-term efficacy of zoledronic acid and denosumab. After 5 years of continuous treatment, both medications significantly increased bone density in older men with a high risk of fracture. Over 90% of patients expressed satisfaction with their treatment. Denosumab demonstrated greater bone density improvements than zoledronic acid, especially in individuals with T-scores exceeding -2.5.

A study 23 investigated the effects of denosumab on the proximal humerus of ovariectomized cynomolgus monkeys. The results indicated that denosumab decreased cortical porosity and increased bone density and strength, suggesting a potential reduction in humerus fracture risk.

However, a study on vitamin D supplementation in children with idiopathic hypercalciuria found that while vitamin D supplementation significantly increased serum 25(OH)D concentration, it had no significant impact on urinary calcium excretion, bone density, or the risk of stone formation in the urinary tract.

Treatment Summary

The study 17 suggests that alendronate/cholecalciferol could be an effective treatment for osteoporosis.

The study 18 suggests that zoledronic acid and denosumab can be effective long-term treatments for osteoporosis.

The study 23 suggests that denosumab might increase bone density and strength in the upper extremities of postmenopausal women.

Benefits and Risks

Benefit Summary

Osteoporosis treatments can increase bone density and decrease the risk of fractures.

Risk Summary

Osteoporosis treatments carry the risk of side effects. These side effects vary depending on the specific medication, emphasizing the importance of discussing treatment options thoroughly with a doctor.

Comparison between Studies

Research Similarities

Many studies focus on evaluating the efficacy of various treatments aimed at increasing bone density.

Research Differences

These studies utilize different medications, research designs, and participant groups.

Consistency and Contradictions in Results

There is a mix of consistency and contradictions in research findings. For example, a treatment found effective in one study might not show the same results in another. This is attributed to factors such as the type of treatment, research design, and participant characteristics.

Considerations for Applying Research to Real Life

Osteoporosis treatment requires individualized approaches, and consultations with a doctor are essential. Choosing the right medication, dosage, and duration of treatment are crucial factors for effective management.

Limitations of Current Research

Many studies focus on the effects of specific treatments, while comparisons of various treatment options are limited. Research on long-term effects and side effects is also insufficient.

Future Research Directions

There is a need for comparative studies evaluating various treatment options and for research addressing long-term effects and side effects. Additionally, personalized treatment approaches tailored to individual genetic and lifestyle factors warrant further exploration.

Conclusion

Bone density declines with age, increasing the risk of fractures. Prevention and treatment of osteoporosis are crucial for extending healthy lifespans. Numerous treatments have been developed, and ongoing research continuously investigates their impact on bone density and efficacy. Future research promises to unveil even safer and more effective treatment options for osteoporosis.

Message for Readers: Early detection and treatment are key for managing osteoporosis. If you have concerns about your bone density, consult a healthcare professional for guidance.

Treatment List

Alendronate/Cholecalciferol, Zoledronic acid, Denosumab, Vitamin D

Literature analysis of 29 papers
Positive Content
25
Neutral Content
3
Negative Content
1
Article Type
9
6
2
6
29
1.

Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis: three years of blinded therapy followed by one year of open therapy.

Author: HarrisS T, WattsN B, JacksonR D, GenantH K, WasnichR D, RossP, MillerP D, LicataA A, ChesnutC H

Increased bone density
Reduced fracture rate

Three years of intermittent cyclic etidronate therapy was found to produce significant increases in spinal and hip bone density, with a significant reduction in vertebral fracture rates in patients at higher fracture risk. The study involved 423 postmenopausal osteoporotic women. Maintenance of bone mass and low fracture rate were observed when etidronate was continued for an additional year.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of one-year cyclical treatment with clodronate on postmenopausal bone loss.

Author: GianniniS, D'AngeloA, MalvasiL, CastrignanoR, PatiT, TroncaR, LibertoL, NobileM, CrepaldiG

Increased bone density

This study of 60 postmenopausal women with bone loss found that cyclical low dose clodronate therapy induced a gain in lumbar spine bone mass.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Bone density changes during two years treatment with tibolone or conjugated estrogens and norgestrel, compared with untreated controls in postmenopausal women.

Author: MilnerM, HarrisonR F, GilliganE, KellyA

Increased bone density

Both tibolone and conjugated estrogens plus sequential norgestrel were effective in preventing osteoporosis, as shown by significant increases in bone mineral density (BMD) compared to a no-treatment control group. Without treatment, BMD declined postmenopausally.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs.

Author: CummingsSteven R, KarpfDavid B, HarrisFran, GenantHarry K, EnsrudKristine, LaCroixAndrea Z, BlackDennis M

Bone mass improvement
Vertebral fracture risk reduction

Improvement in spine bone mineral density only partially explains the observed reduction in risk of vertebral fracture with antiresorptive drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

6.

Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women.

Author: CranneyAnn, WellsGeorge, WillanAndrew, GriffithLauren, ZytarukNicole, RobinsonVivian, BlackDennis, AdachiJonathan, SheaBeverley, TugwellPeter, GuyattGordon,

Increased bone density
Reduced nonvertebral fractures
Reduced vertebral fractures
Gastrointestinal side effects

Alendronate increases bone density in postmenopausal women and reduces the risk of both vertebral and nonvertebral fractures. The effect on fractures appears consistent across all fracture types.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Meta-analyses of therapies for postmenopausal osteoporosis. III. Meta-analysis of risedronate for the treatment of postmenopausal osteoporosis.

Author: CranneyAnn, TugwellPeter, AdachiJonathan, WeaverBruce, ZytarukNicole, PapaioannouAlexandra, RobinsonVivian, SheaBeverley, WellsGeorge, GuyattGordon,

Increased bone density
Reduced nonvertebral fractures
Reduced vertebral fractures

Risedronate significantly reduces the risk of both vertebral and nonvertebral fractures in postmenopausal women. It also increases bone density of the lumbar spine and femoral neck.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Meta-analyses of therapies for postmenopausal osteoporosis. VI. Meta-analysis of calcitonin for the treatment of postmenopausal osteoporosis.

Author: CranneyAnn, TugwellPeter, ZytarukNicole, RobinsonVivian, WeaverBruce, SheaBeverley, WellsGeorge, AdachiJonathan, WaldeggerLisa, GuyattGordon,

Increased bone density
Reduced vertebral fractures

Calcitonin likely increases bone density in postmenopausal women and reduces the risk of vertebral fracture.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women.

Author: PapadimitropoulosEmmanuel, WellsGeorge, SheaBeverley, GillespieWilliam, WeaverBruce, ZytarukNicole, CranneyAnn, AdachiJonathan, TugwellPeter, JosseRobert, GreenwoodCarol, GuyattGordon,

Increased bone density
Reduced nonvertebral fractures
Reduced vertebral fractures
Discontinuing medication

Vitamin D decreases vertebral fractures and may decrease nonvertebral fractures in postmenopausal women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial.

Author: PrestwoodKaren M, KennyAnne M, KleppingerAlison, KulldorffMartin

Bone density increase
Bone turnover reduction
Breast tenderness
Endometrial changes

A dosage of 0.25 mg/d of 17beta-estradiol increased bone density of the hip, spine, and total body, and reduced bone turnover, with minimal adverse effects in older women.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Prevalence and treatment of decreased bone density in renal transplant recipients: a randomized prospective trial of calcitriol versus alendronate.

Author: JefferyJohn R, LeslieWilliam D, KarpinskiMartin E, NickersonPeter W, RushDavid N

Increased BMD
Fractures

Alendronate and calcitriol, both with calcium supplementation, resulted in significant increases in bone mineral density in long-term renal transplant recipients with reduced bone mineral density. Alendronate may be more effective at the spine, but further studies are needed to confirm this and to determine long-term benefits and effects on fracture rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Site-specific differential effects of once-yearly zoledronic acid on the hip assessed with quantitative computed tomography: results from the HORIZON Pivotal Fracture Trial.

Author: YangL, SychevaA V, BlackD M, EastellR

Improved bone density

This study investigated the effects of zoledronic acid on bone density in different regions of the hip, demonstrating a significant increase in bone density compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density.

Author: NaylorK E, BradburnM, PaggiosiM A, GossielF, PeelN F A, McCloskeyE V, WalshJ S, EastellR

This study looked at the effects of stopping different types of bisphosphonate medications (ibandronate, alendronate, risedronate) used to treat osteoporosis in postmenopausal women. After stopping treatment, all groups experienced an increase in bone turnover markers (BTMs), indicating increased bone breakdown, and a decrease in bone mineral density (BMD) in the hip, although levels did not return to their original levels before treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials.

Author: BouxseinMary L, EastellRichard, LuiLi-Yung, WuLucy A, de PappAnne E, GrauerAndreas, MarinFernando, CauleyJane A, BauerDouglas C, BlackDennis M,

BMD improvement
Fracture risk reduction
Osteoporosis treatment

This meta-regression of 38 placebo-controlled trials of 19 therapeutic agents found that greater improvements in bone mineral density (BMD) were strongly associated with greater reductions in vertebral and hip fractures but not nonvertebral fractures. For example, a 2% or 6% improvement in total hip BMD might be associated with a 28% or 66% reduction in vertebral fracture risk, respectively.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Effects of four-year cyclic versus two-year daily teriparatide treatment on volumetric bone density and bone strength in postmenopausal women with osteoporosis.

Author: GanapathyAravinda, NievesJeri W, KeavenyTony M, CosmanFelicia

Bone mineral density increase
Bone strength increase

The gains in volumetric BMD and bone strength for an equivalent dose of TPTD did not depend on whether it was administered every day over two years or cyclically over four years.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

16.

A Prospective Longitudinal Study of the Effects of Eslicarbazepine Acetate Treatment on Bone Density and Metabolism in Patients with Focal-Onset Epilepsy.

Author: HirschMartin, ImmischIlka, KnakeSusanne, Schulze-BonhageAndreas

Epilepsy treatment
Bone health issues

This study investigated the potential adverse effects of eslicarbazepine acetate (ESL), a third-generation anti-seizure medication, on bone health. It aimed to determine whether ESL exposure for 12 months could affect bone mineral density (BMD) and bone turnover markers.

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Evaluation of bone density and hand grip strength in the course of drug treatment for osteoporosis : A real-world study.

Author: SchröderGuido, HothIvonne, FlachsmeyerDirk, DutzkeMario, AndresenJulian Ramin, AndresenReimer, SchoberHans-Christof

Vertebral fractures

This clinical investigation assesses the physical performance in osteoporotic patients undergoing drug treatment for years by measuring hand grip strength and bone mineral density. The study aims to detect the time until the occurrence of vertebral fractures and influencing factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Effects of four-year cyclic versus two-year daily teriparatide treatment on volumetric bone density and bone strength in postmenopausal women with osteoporosis.

Author: GanapathyAravinda, NievesJeri W, KeavenyTony M, CosmanFelicia

Bone mineral density increase
Bone strength increase

The gains in volumetric BMD and bone strength for an equivalent dose of TPTD did not depend on whether it was administered every day over two years or cyclically over four years.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

22.

Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis.

Author: FurukawaMitsuru, OkuyamaKunimasa, NinomiyaKen, MiyamotoTakeshi, YatoYoshiyuki

Spine Fractures

The study investigated the characteristics and bone metabolism markers of patients with diffuse idiopathic skeletal hyperostosis (DISH) who also have low bone density, to determine the need for osteoporosis medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Denosumab treatment is associated with decreased cortical porosity and increased bone density and strength at the proximal humerus of ovariectomized cynomolgus monkeys.

Author: HaiderIfaz T, SawatskyAndrew, ZhuYing, PageRebecca, KostenuikPaul J, BoydSteven K, EdwardsW Brent

DMAb treatment
Humeral fracture prevention

Denosumab treatment in women with postmenopausal osteoporosis increases bone mineral density and strength in the humerus, which could explain the observed reduction in humeral fracture rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Inter-Rater Reliability of Hounsfield Units as a Measure of Bone Density: Applications in the Treatment of Thoracolumbar Fractures.

Author: UllrichBernhard Wilhelm, SchwarzFalko, McLeanAaron Lawson, MendelThomas, KadenIngmar, HeinElizabeth, LattauschkeAnne, BeyerJulia, HofmannGunther Olaf, KlaukeFriederike, SchenkPhilipp

Accurate bone quality assessment
Reliable HU measurement

Hounsfield unit (HU) measurement from native CT scans showed very high inter-rater reliability and correlated closely with quantitative CT (qCT)-derived bone mineral density (BMD) values. It is a suitable tool to assess bone quality in thoracolumbar spinal trauma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Abaloparatide treatment increases bone formation, bone density and bone strength without increasing bone resorption in a rat model of hindlimb unloading.

Author: TeguhDian A, NustadJordan L, CravenAmanda E, BrooksDaniel J, ArltHeike, HuDorothy, BaronRoland, LanskeBeate, BouxseinMary L

Improved bone strength
Increased bone density

This study found that abaloparatide, a drug that promotes bone formation, effectively increased bone density and strength in both normal weight-bearing and hindlimb-unloaded rats. This suggests that abaloparatide may be a promising treatment for disuse osteoporosis in humans.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Bone density, microarchitecture and tissue quality after 1 year of treatment with dolutegravir/abacavir/lamivudine.

Author: Soldado-FolgadoJade, Lerma-ChippirrazElisabeth, Arrieta-AldeaItziar, BujosaDaniel, García-GiraltNatalia, Pineda-MoncusiMarta, Trenchs-RodríguezMarta, Villar-GarcíaJudit, González-MenaAlicia, Díez-PérezAdolfo, BrownTodd T, KnobelHernando, Güerri-FernándezRobert

DTG/ABC/3TC
bone quality
BMD
bone microarchitecture

This study investigated the impact of dolutegravir/abacavir/lamivudine-based antiretroviral therapy (ART) on bone health parameters in ART-naive individuals with HIV. After 48 weeks of treatment, BMD and trabecular bone score decreased, while bone tissue quality improved. The immune system's state at ART initiation appeared to be related to bone quality recovery. The study highlights the need for a comprehensive approach to assess bone toxicity in ART-treated patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.