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Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action.

Author: CatalánMarcelo A, CidLuis Pablo, Julio-KalajzićFrancisca, NiemeyerMaría Isabel, SepúlvedaFrancisco V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lubiprostone's effect on the distal intestinal epithelium is mediated by CFTR activation, not ClC-2.
Paper Details　
Original Abstract of the Article :
Lubiprostone, a 20-carbon synthetic fatty acid used for the treatment of constipation, is thought to act through an action on Cl<sup>-</sup> channel ClC-2. Short chain fatty acids (SCFAs) are produced and absorbed in the distal intestine. We explore whether SCFAs affect ClC-2, re-examine a possible ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464869/

データ提供：米国国立医学図書館（NLM）

Lubiprostone: Exploring the Role of Chloride Channel ClC-2

This study examines the mechanism of action of [lubiprostone], a [synthetic fatty acid] used to treat [constipation]. The authors investigate the role of [chloride channel ClC-2] in the intestinal effects of lubiprostone and explore the potential influence of [short chain fatty acids (SCFAs)] on ClC-2. The research is conducted using both [cell culture] and [animal models]. Imagine this as a journey through the desert to explore the different types of plants and their effects on the ecosystem.

Deciphering the Intestinal Effects of Lubiprostone

The study provides evidence that ClC-2 does not play a direct role in the intestinal effects of lubiprostone. Instead, the authors suggest that [CFTR] is the primary target of lubiprostone's action. This research is like discovering a new oasis in the desert - one that provides a different source of water than previously thought.

Understanding the Role of ClC-2 in Intestinal Function

The study highlights the complex interplay of [SCFAs], [ClC-2], and [CFTR] in intestinal function. The authors suggest that SCFAs might have a physiological effect on ClC-2, but they emphasize that ClC-2 is not the main target of lubiprostone's action. This research is like learning about the intricate relationships between different species in the desert - how they cooperate and compete for resources.

Dr. Camel's Conclusion

This study provides valuable insights into the mechanism of action of lubiprostone and the complex interplay of different ion channels in intestinal function. The findings suggest that CFTR, not ClC-2, is the primary target of lubiprostone's action. This research is like a journey through the desert, uncovering new knowledge and expanding our understanding of the world around us.

Date :
  1. Date Completed 2021-03-31
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

32722648

DOI: Digital Object Identifier

PMC7464869

Related Literature

Article Analysis
・Effects of lubiprostone
SNS
PICO Info
in preparation
Languages

English

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