Effects of lubiprostone: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major research findings

Lubiprostone is a medication used to treat constipation. 11 It works by activating chloride channels in the intestines, which increases fluid secretion and helps to soften the stool. 13 Research has shown that lubiprostone can be effective for treating chronic constipation, 1 opioid-induced constipation, 3 and constipation-predominant irritable bowel syndrome. 2 Additionally, lubiprostone may also improve intestinal permeability, 27 which could have implications for the treatment of other conditions such as inflammatory bowel disease. 28 Furthermore, lubiprostone has been shown to be safe and well-tolerated in most patients. 11 However, some patients may experience side effects such as diarrhea, nausea, or abdominal pain. 4 , 10

Benefits and Risks

Benefit Summary

Lubiprostone has been found to be effective for treating various types of constipation, including chronic constipation, opioid-induced constipation, and constipation-predominant irritable bowel syndrome. 1 , 11 , 17 Additionally, lubiprostone is generally well-tolerated and safe for most patients. 11 , 3

Risk Summary

While lubiprostone is generally safe, some patients may experience side effects such as diarrhea, nausea, or abdominal pain. 4 , 10 The effectiveness of lubiprostone can vary between individuals. 26 , 2

Comparison Across Studies

Similarities Across Studies

Many studies have demonstrated the efficacy of lubiprostone in treating constipation. 1 , 11 , 17 Moreover, lubiprostone is generally considered a safe medication. 11 , 3 However, some patients may experience side effects such as diarrhea, nausea, or abdominal pain. 4 , 10 The effectiveness of lubiprostone can vary between individuals. 26 , 2

Differences Across Studies

The effectiveness of lubiprostone may differ depending on the type and severity of constipation. 2 Some studies suggest that lubiprostone may be more effective than traditional laxatives. 6 , 2 However, further research is needed to determine how long lubiprostone’s effects last. 26

Consistency and Contradictions in Findings

The effectiveness of lubiprostone can vary between individuals. 26 , 2 Further research is needed to determine how long lubiprostone’s effects last. 26

Considerations for Real-World Application

Lubiprostone is a medication used to treat constipation. 11 It works by activating chloride channels in the intestines, which increases fluid secretion and helps to soften the stool. 13 Research has shown that lubiprostone can be effective for treating chronic constipation, 1 opioid-induced constipation, 3 and constipation-predominant irritable bowel syndrome. 2 Additionally, lubiprostone may also improve intestinal permeability, 27 which could have implications for the treatment of other conditions such as inflammatory bowel disease. 28 Lubiprostone is generally well-tolerated and safe for most patients. 11 , 3 However, some patients may experience side effects such as diarrhea, nausea, or abdominal pain. 4 , 10 It’s important to consult with your doctor to determine if lubiprostone is right for you and to discuss any potential side effects. 4 , 2 Additionally, lubiprostone may interact with other medications, so it is important to inform your doctor of all medications you are currently taking. 2 It is not recommended for use during pregnancy or breastfeeding. 2

Limitations of Current Research

Further research is needed to better understand the long-term effects of lubiprostone. 26 It is important to conduct research on the long-term safety of lubiprostone. 2 Additionally, more research is needed to compare lubiprostone to other laxatives and to investigate its potential benefits for improving intestinal health. 26 , 2 , 6 , 27 , 28

Future Research Directions

Further research is needed to better understand the long-term effects of lubiprostone. 26 It is important to conduct research on the long-term safety of lubiprostone. 2 Additionally, more research is needed to compare lubiprostone to other laxatives and to investigate its potential benefits for improving intestinal health. 26 , 2 , 6 , 27 , 28

Conclusion

Lubiprostone is a medication used to treat constipation. 11 It works by activating chloride channels in the intestines, which increases fluid secretion and helps to soften the stool. 13 Research has shown that lubiprostone can be effective for treating chronic constipation, 1 opioid-induced constipation, 3 and constipation-predominant irritable bowel syndrome. 2 Additionally, lubiprostone may also improve intestinal permeability, 27 which could have implications for the treatment of other conditions such as inflammatory bowel disease. 28 Lubiprostone is generally well-tolerated and safe for most patients. 11 , 3 However, some patients may experience side effects such as diarrhea, nausea, or abdominal pain. 4 , 10 It’s important to consult with your doctor to determine if lubiprostone is right for you and to discuss any potential side effects. 4 , 2 Additionally, lubiprostone may interact with other medications, so it is important to inform your doctor of all medications you are currently taking. 2 It is not recommended for use during pregnancy or breastfeeding. 2

Literature analysis of 28 papers
Positive Content
25
Neutral Content
0
Negative Content
3
Article Type
4
5
4
5
28
1.

Lubiprostone Accelerates Intestinal Transit and Alleviates Small Intestinal Bacterial Overgrowth in Patients With Chronic Constipation.

Author: SarosiekIrene, BashashatiMohammad, AlvarezAlicia, HallMark, ShankarNagasri, GomezYvette, McCallumRichard W, SarosiekJerzy

Effective for chronic constipation

Lubiprostone is an effective treatment for chronic constipation (CC). This study was designed to investigate whether lubiprostone alters gastrointestinal transit and affects SIBO in patients with constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis.

Author: BlackChristopher J, BurrNicholas E, QuigleyEamonn M M, MoayyediPaul, HoughtonLesley A, FordAlexander C

IBS-C treatment

This network meta-analysis compares the efficacy of various secretagogues approved for irritable bowel syndrome with constipation (IBS-C). The relative efficacy of these drugs is unclear due to the lack of head-to-head randomized controlled trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Efficacy and Safety of Lubiprostone in Patients with Opioid-Induced Constipation: Phase 3 Study Results and Pooled Analysis of the Effect of Concomitant Methadone Use on Clinical Outcomes.

Author: SpieringsEgilius L H, DrossmanDouglas A, CryerByron, Mazen JamalM, Losch-BeridonTaryn, MareyaShadreck M, WangMartin

Relieve OIC symptoms

Oral lubiprostone was effective in relieving symptoms of opioid-induced constipation (OIC) in patients with chronic noncancer pain. Methadone use was associated with a lower response to lubiprostone treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

The Efficacy and Safety of Lubiprostone for Constipation in Cancer Patients Compared with Non-cancer Patients: A Retrospective Cohort Study.

Author: SadaHikaru, KajizonoMakoto, UshioSouichiro, EsumiSatoru, KitamuraYoshihisa, SendoToshiaki

Effective in cancer
Improved BM frequency
Caution in low BMI
Diarrhea and nausea
High discontinuation rate

This study evaluated the efficacy and safety of lubiprostone for constipation in cancer patients. Lubiprostone was as effective in cancer patients as in non-cancer patients, but it was associated with a higher incidence of diarrhea and nausea in cancer patients, especially those with a low BMI.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

A meta-analysis of randomized controlled trials of the addition of lubiprostone to bowel preparation before colonoscopy.

Author: LiPeng, HeXue-Qian, DongJie, DuJing

Improved bowel prep
Safe

The addition of lubiprostone to the bowel preparation regimen prior to colonoscopy is effective and safe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Efficacy, safety, and tolerability of lubiprostone for the treatment of non-alcoholic fatty liver disease in adult patients with constipation: The LUBIPRONE, double-blind, randomised, placebo-controlled study design.

Author: KessokuTakaomi, ImajoKento, KobayashiTakashi, HondaYasushi, KatoTakayuki, OgawaYuji, TomenoWataru, KatoShingo, HigurashiTakuma, YonedaMasato, KirikoshiHiroyuki, KubotaKazumi, TaguriMasataka, YamanakaTakeharu, UsudaHaruki, WadaKoichiro, SaitoSatoru, NakajimaAtsushi

Gut permeability suppression
NAFLD treatment

This paper outlines the protocol for a randomized, double-blind, placebo-controlled trial investigating the efficacy, safety, and tolerability of lubiprostone (LUB) versus placebo in suppressing gut permeability in patients with non-alcoholic fatty liver disease (NAFLD) and constipation. NAFLD, including non-alcoholic steatohepatitis (NASH), is a prevalent chronic liver disorder with progression linked to increased gut permeability and endotoxins. LUB, a type 2 chloride channel activator, acts as a laxative for constipation and has shown potential in reducing gut permeability and blood endotoxin levels in healthy volunteers. This study aims to explore the benefits of LUB for NAFLD/NASH patients.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis.

Author: LuthraPavit, CamilleriMichael, BurrNicholas E, QuigleyEamonn M M, BlackChristopher J, FordAlexander C

Constipation treatment efficacy

This network meta-analysis compared the efficacy of different drugs used to treat chronic idiopathic constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Constipation in Patients With Chronic Kidney Disease.

Author: ChaRa Ri, ParkSeon-Young, CamilleriMichael,

Improved bowel function
Reduced phosphate absorption
Reno-protective effects
Adverse effects
Insufficient efficacy

This review outlines the mechanisms and management of constipation in patients with chronic kidney disease (CKD). It discusses common causes, impact on overall health, and available treatment options, including lactulose, lubiprostone, linaclotide, plecanatide, tenapanor, and prucalopride.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders.

Author: CryerByron, DrossmanDouglas A, CheyWilliam D, WebsterLynn, HabibiSepideh, WangMartin

Constipation treatment
Lubiprostone
Nausea

Lubiprostone is a medication used to treat constipation in adults and women. It is generally well tolerated, with nausea being the most common side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Real-World Comparison of Elobixibat and Lubiprostone Treatment in Patients with Chronic Constipation: A Propensity Score-Matched Analysis.

Author: EguchiTakaaki, YoshizakiTetsuya, IkeokaSeitaro, TakagiMegumi, FujinamiMaho, MatsudaTatsuya, YamaguchiTsubasa, NonakaTakahiro, AmiokaShohei, KatayamaNorio, InoueKazuki, MatsumotoMasanori, MomoseKenji, SakoTomoya, NodaMari, MorisawaToshiyuki, OkadaAkihiko

Few side effects
Improved constipation
Soft stools

Elobixibat, a new laxative, was found to be effective in treating mildly symptomatic chronic constipation with fewer adverse events compared to lubiprostone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Diarrhea-Predominant and Constipation-Predominant Irritable Bowel Syndrome: Current Prescription Drug Treatment Options.

Author: WechslerEmily V, ShahEric D

IBS symptom relief

This review summarizes the clinical profiles of efficacy, safety, and tolerability of prescription drugs for irritable bowel syndrome (IBS), including cost-effectiveness of drugs for diarrhea-predominant IBS and constipation-predominant IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Clinical Overview and Considerations for the Management of Opioid-induced Constipation in Patients With Chronic Noncancer Pain.

Author: ViscusiEugene R

Opioid-induced constipation

Prescription medications for opioid-induced constipation (OIC) include peripherally acting µ-opioid receptor antagonists (PAMORA) and chloride channel activators. These medications are effective for improving OIC in patients with chronic noncancer pain, but potential gastrointestinal side effects need to be considered.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Prevalence and predictors of laxatives use in clozapine-related constipation: an observational study.

Author: NakamuraMasaru, NagamineTakahiko

Constipation

Clozapine-induced constipation is a common problem in treatment-resistant schizophrenia patients. This study found that half of the subjects required laxatives, and that longer disease duration, lower fasting blood glucose, and lower insulin resistance were associated with laxative use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

18.

Management of Opioid-Induced and Non-Opioid-Related Constipation in Patients With Cancer: Systematic Review and Meta-Analysis.

Author: GinexPamela K, HansonBrian J, LeFebvreKristine B, LinYufen, MoriartyKerri A, MaloneyChristine, VrabelMark, MorganRebecca L

Complementary approaches
Lifestyle management
Non-opioid constipation relief
Opioid constipation relief
Pharmacological management

For patients with cancer and opioid-induced constipation, osmotic or stimulant laxatives are moderately beneficial, while methylnaltrexone, naldemedine, and electroacupuncture offer small benefits. For non-opioid-related constipation, naloxegol, prucalopride, lubiprostone, and linaclotide show moderate benefits, while acupuncture has trivial benefit.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action.

Author: CatalánMarcelo A, Julio-KalajzićFrancisca, NiemeyerMaría Isabel, CidLuis Pablo, SepúlvedaFrancisco V

Constipation treatment

Lubiprostone's effect on the distal intestinal epithelium is mediated by CFTR activation, not ClC-2.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.

Author: ChangLin, CheyWilliam D, ImdadAamer, AlmarioChristopher V, BharuchaAdil E, DiemSusan, GreerKatarina B, HansonBrian, HarrisLucinda A, KoCynthia, MuradM Hassan, PatelAmit, ShahEric D, LemboAnthony J, SultanShahnaz

CIC treatment

Chronic idiopathic constipation (CIC) is a common condition. This clinical practice guideline provides evidence-based recommendations for the pharmacological treatment of CIC in adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone.

Author: YamamotoTakatsugu, OsumiShun, YanagisawaDaisuke, YamatoHiroshi, AoyagiHitoshi, IsonoAkari, AbeKoichiro, KitaHiroto

Herbal medicines for lubiprostone nausea
Prokinetics for lubiprostone nausea

Concomitant use of prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Efficacy and safety of lubiprostone for the treatment of functional constipation in Chinese adult patients: A multicenter, randomized, double-blind, placebo-controlled trial.

Author: XiaoYing Lian, DaiNing, HeShui Xiang, TianDe An, LiuSi De, TianZi Bin, WangXiao Yan, LiYan Qing, HouXiao Hua, FangXiu Cai, WenZhi Li, ZengWei Zheng, XuHong, SunMing Jun, LiuYu Lan, WuYong Dong, ShenXi Zhong, LiuXiao Wei, LiuDe Liang, ChenMin Hu

Lubiprostone constipation

This study aimed to evaluate the efficacy and safety of lubiprostone, a locally acting type-2 chloride channel activator, in Chinese adults with functional constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Effects of lubiprostone on human uterine smooth muscle cells.

Author: CuppolettiJohn, MalinowskaDanuta H, ChakrabartiJayati, UenoRyuji

Lubiprostone is a new drug that works differently than prostaglandins to treat constipation. It acts locally on chloride channels in the gut without affecting prostaglandin receptors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Management of Opioid-induced Constipation in Older Adults.

Author: HorriganJamie, BhumiSriya, MillerDavid, JafriMikram, TadrosMicheal

OIC treatment
None reported

This review provides guidance on managing opioid-induced constipation (OIC) in older adults. It recommends considering nonpharmacologic interventions and over-the-counter laxatives before moving to prescription opioid receptor antagonists. The review emphasizes the importance of individualizing treatment based on the complex pharmacokinetic profile of aging individuals.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Recent advances in understanding and managing chronic constipation.

Author: PrichardDavid O, BharuchaAdil E

Constipation treatment
Undesirable side effects

Constipation is a common condition that can affect physical, mental, and social functioning. Current guidelines recommend empiric therapy, but limited surveys suggest that fewer than half of treated individuals are satisfied with treatment. Newer therapeutic agents, such as secretagogues and pro-kinetics, may offer more effective treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers.

Author: KatoTakayuki, HondaYasushi, KuritaYusuke, IwasakiAkito, SatoTakamitsu, KessokuTakaomi, UchiyamaShiori, OgawaYuji, OhkuboHidenori, HigurashiTakuma, YamanakaTakeharu, UsudaHaruki, WadaKoichiro, NakajimaAtsushi

Leaky gut syndrome

This study investigates whether lubiprostone, a drug used for chronic constipation, can improve disturbed intestinal permeability, a key feature of 'leaky gut syndrome.' While leaky gut syndrome is associated with various diseases, no drugs have been shown to improve intestinal permeability in humans. The study explores lubiprostone as a potential preventative strategy for leaky gut syndrome.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Lubiprostone Induces Claudin-1 and Protects Intestinal Barrier Function.

Author: NishiiNorio, OshimaTadayuki, LiMin, EdaHirotsugu, NakamuraKumiko, TamuraAkio, OgawaTomohiro, YamasakiTakahisa, KondoTakashi, KonoTomoaki, TozawaKatsuyuki, TomitaToshihiko, FukuiHirokazu, MiwaHiroto

Intestinal barrier function

Lubiprostone is a chloride channel activator that is said to reduce epithelial permeability. This study evaluated the effects of lubiprostone on intestinal barrier function in vitro.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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