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The concept and management of acute episodes of treatment-resistant bipolar disorder: a systematic review and exploratory meta-analysis of randomized controlled trials.

Author: AnastasiaAnnalisa, BerkMichael, CarvalhoAndré F, FornaroMichele, FuscoAndrea, SimKang, SolmiMarco, VietaEduard, de BartolomeisAndrea

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review examines research on treatment-resistant bipolar disorder (TRBD). While several interventions exist, including pramipexole, electroconvulsive therapy (ECT), and clozapine, more research is needed. This includes larger, better-designed trials with consistent definitions of TRBD.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The definitions of treatment-resistant bipolar disorder (TRBD) have varied across studies. Additionally, its management is clinically challenging. An updated synthesis and appraisal of the available evidence is needed. METHODS: A systematic search of major electronic databases from ince...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2020.07.109

データ提供：米国国立医学図書館（NLM）

Managing Acute Episodes of Treatment-Resistant Bipolar Disorder: A Review

The field of [bipolar disorder treatment] is continuously seeking effective approaches to manage [treatment-resistant bipolar disorder (TRBD)]. This systematic review and exploratory meta-analysis of randomized controlled trials aims to provide a [comprehensive overview of the available evidence] for the management of TRBD, focusing on both [pharmacological and non-pharmacological interventions]. The review addresses the [variability in definitions of TRBD across studies] and the [clinical challenges] associated with managing this complex condition.

Promising Interventions for Treatment-Resistant Bipolar Disorder

The review identifies several [promising interventions] for TRBD, including [pramipexole, electroconvulsive therapy (ECT), and clozapine]. The meta-analysis suggests that [rapid up-titration of clozapine] may be [effective for TRBD mania] with [minimal adverse events]. The review confirms the efficacy of [ECT] for [treatment-resistant acute bipolar depression (TRBD-De)] similar to its effectiveness for [treatment-resistant unipolar depression]. It's like finding a hidden oasis in the desert, a place of respite and healing for those navigating the challenging terrain of bipolar disorder.

The Need for Further Research and Improved Definitions

The review highlights the [need for further research] with larger and better-designed trials to [evaluate the effectiveness of various interventions] for TRBD. It also emphasizes the importance of establishing [more uniform operational definitions] for TRBD to facilitate [consistent research and clinical practice]. This review serves as a valuable resource for clinicians seeking to improve the [management of TRBD] and enhance patient outcomes.

Dr.Camel's Conclusion

This systematic review provides a valuable overview of the [current evidence] for managing [treatment-resistant bipolar disorder]. It offers insights into [promising interventions] and underscores the need for [further research] to develop more effective and personalized treatment strategies.

Date :
  1. Date Completed 2021-02-15
  2. Date Revised 2021-02-15
Further Info :

Pubmed ID

32750614

DOI: Digital Object Identifier

10.1016/j.jad.2020.07.109

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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