Paper Details
- Home
- Paper Details
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding.
Author: BakulevVasiliy, CorreaMerce, DragacevicVladimir, KalabaPredrag, LubecGert, NeriJulia, PiflChristian, PresbyRose E, RobertsonEmily, RotoloRenee A, SalamoneJohn D, VolkovaNatalia N, YangJen-Hau
Original Abstract of the Article :
Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting agent tetrabenazine can reliably induce motivational deficits in rats, as evidenced by a s...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://pubmed.ncbi.nlm.nih.gov/32770257
データ提供：米国国立医学図書館（NLM）
(S,S)-CE-158: A Potential New Ally in the Battle Against Motivational Deficits
The world of neuropharmacology is constantly searching for new and effective treatments for various neurological conditions. This study explores the potential of (S,S)-CE-158, a modafinil analog, to address motivational deficits, which are often associated with depression and other disorders.
The researchers investigated the effects of (S,S)-CE-158 on dopamine transporter binding and motivational behavior in rats. They found that (S,S)-CE-158, similar to modafinil, acted as an atypical dopamine transporter blocker. Interestingly, (S,S)-CE-158 was able to reverse the motivational deficits induced by tetrabenazine, a dopamine depleting agent, and enhance progressive ratio responding in rats. These findings suggest that (S,S)-CE-158 might be a promising candidate for treating motivational symptoms in individuals with depression and other conditions.
A New Hope for Addressing Motivational Deficits
This study provides encouraging evidence for the potential of (S,S)-CE-158 as a therapeutic agent for addressing motivational deficits. The ability of this modafinil analog to reverse tetrabenazine-induced motivational deficits and enhance progressive ratio responding suggests that it may be a valuable tool for improving motivation and engagement in individuals with various conditions.
Navigating the Complexities of Motivation
This research underscores the complex interplay between dopamine and motivation. The findings highlight the potential of dopamine transporter blockers, like (S,S)-CE-158, to influence motivation and potentially improve the lives of individuals struggling with motivational deficits.
Dr.Camel's Conclusion
Just as a camel must be motivated to cross vast deserts, humans need motivation to navigate the challenges of life. This study offers a beacon of hope for individuals struggling with motivational deficits, demonstrating the potential of (S,S)-CE-158 to reignite their passion and drive, helping them to overcome obstacles and achieve their goals.
Date :
- Date Completed 2021-01-26
- Date Revised 2021-11-02
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.