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Chronic suppression for six months compared with intermittent lesional therapy of recurrent genital herpes using oral acyclovir: effects on lesions and nonlesional prodromes.

Author: FoxR, KeeneyR, LevenduskyP, Nusinoff-LehrmanS, RolandS, SacksS L, StiverH G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 47 patients with frequently recurring genital herpes found that oral acyclovir was effective in reducing outbreaks for at least six months. While acyclovir significantly delayed the first recurrence, the effect did not persist after treatment stopped.
Paper Details　
Original Abstract of the Article :
Forty-seven patients with frequently recurrent genital herpes were treated with 200 mg of acyclovir or placebo capsules taken orally three times daily for six months; the drug was then withdrawn. Active lesional events were treated with open-labeled 200-mg acyclovir capsules five times daily for fiv...See full text at original site
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引用元：
https://doi.org/10.1097/00007435-198801000-00013

データ提供：米国国立医学図書館（NLM）

Chronic Suppression vs. Intermittent Lesional Therapy: A Comparison of Acyclovir Treatments for Genital Herpes

[Genital herpes] is a common viral infection that can cause recurrent outbreaks. This study investigates the efficacy of two different treatment approaches for [recurrent genital herpes] using [acyclovir]: [chronic suppression] and [intermittent lesional therapy]. This is like comparing two different methods of traveling through a desert: one involves a constant, steady journey, while the other involves bursts of activity followed by periods of rest.

Chronic Suppression: A Long-Term Approach to Genital Herpes Management

The study found that [chronic suppression] with [acyclovir] was effective in reducing the frequency of [genital herpes] outbreaks for at least [6 months]. This is like finding a reliable source of water in the desert, providing sustained relief from the challenges of [genital herpes] outbreaks. However, the study also noted that [nonlesional prodromes] were more common during [acyclovir] suppression, suggesting a complex interplay between the medication and the virus.

Genital Herpes Treatment: Finding the Right Path Through the Desert of Outbreaks

This study highlights the need for individualized treatment approaches for [recurrent genital herpes], considering the patient's individual needs and preferences. This is like carefully choosing the right path through the desert, taking into account the specific challenges and resources available. Further research is needed to optimize treatment strategies for [genital herpes] and to develop new therapies that minimize side effects and improve long-term outcomes.

Dr. Camel's Conclusion

This study provides valuable insights into the potential of [acyclovir] for managing [recurrent genital herpes]. While [chronic suppression] might offer a viable option for some patients, the study emphasizes the need for continued monitoring and individualization of treatment plans. This is like learning to navigate the desert landscape, understanding the complexities of the terrain and adapting our strategies as needed to find the best way forward.
Date :
  1. Date Completed 1988-05-16
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3282336

DOI: Digital Object Identifier

10.1097/00007435-198801000-00013

Related Literature

Article Analysis
・Effective treatment of genital herpes
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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