Paper Details

  1. Home
  2. Paper Details

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and "cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats.

Author: ChenGao, GaoLiansheng, LenahanCameron, LiJianru, LiTao, QinBing, WangChun, XuWeilin, YingGuangyu, ZhaoTengfei, ZhuYongjian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the neuroprotective role of PFKFB3 in traumatic spinal cord injury (t-SCI). PFKFB3 activation by meclizine significantly enhanced glycolysis, attenuated t-SCI-induced spinal cord injury, and alleviated neurological impairment.
Paper Details　
Original Abstract of the Article :
Apoptosis is a vital pathological factor that accounts for the poor prognosis of traumatic spinal cord injury (t-SCI). The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is a critical regulator for energy metabolism and proven to have antiapoptotic effects. This study aimed to investi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563815/

データ提供：米国国立医学図書館（NLM）

PFKFB3: A Potential Oasis in the Desert of Spinal Cord Injury

The aftermath of a [traumatic spinal cord injury (t-SCI)] can be devastating, leaving individuals with limited mobility and facing a challenging path to recovery. This study explores the potential of [PFKFB3], a crucial regulator of energy metabolism, as a protective agent in the desert landscape of spinal cord injury. It's like seeking a vital resource in a harsh environment, hoping to mitigate the damage and support recovery.

A Pathway to Healing in the Desert

The researchers meticulously investigated the role of [PFKFB3] in the aftermath of [t-SCI]. They discovered that [PFKFB3] plays a protective role in neurons, potentially mitigating the damage caused by the injury. It's like finding a hidden spring in the desert, offering a source of strength and resilience to help neurons survive and potentially regenerate.

Hope for Recovery in the Arid Landscape

This research offers hope for individuals facing the devastating consequences of [t-SCI]. By exploring the potential of [PFKFB3] as a protective agent, researchers may be able to develop new therapeutic strategies to aid in recovery and improve outcomes. It's a reminder that even in the most barren of deserts, there is potential for healing and growth, offering a ray of hope for individuals navigating the challenges of spinal cord injury.

Dr.Camel's Conclusion

This study highlights the potential of [PFKFB3] as a promising target for developing new therapies for [t-SCI]. It underscores the importance of understanding the complex interplay between energy metabolism and neuronal survival, and the need for further research to explore this pathway for potential therapeutic benefit. It's a reminder that even in the face of adversity, the desert of spinal cord injury may hold hidden oases of hope, waiting to be discovered and harnessed for healing.

Date :
  1. Date Completed 2021-06-24
  2. Date Revised 2021-06-24
Further Info :

Pubmed ID

32841050

DOI: Digital Object Identifier

PMC7563815

Related Literature

Article Analysis
・Effects of meclizine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.