Spectroscopic study of in situ-formed metallocomplexes of proton pump inhibitors in water.

Author: AbramenkoNikita, AntonyováVeronika, BrogyányiTereza, DytrychPetr, Ikeda-SaitoMasao, JakubekMilan, KaplánekRobert, KejíkZdeněk, MartásekPavel, PajkováMartina, SýkoraDavid, TatarAmeneh, VeseláKateřina

Paper Details 
Original Abstract of the Article :
Proton pump inhibitors, such as omeprazole, pantoprazole and lansoprazole, are an important group of clinically used drugs. Generally, they are considered safe without direct toxicity. Nevertheless, their long-term use can be associated with a higher risk of some serious pathological states (e.g. am...See full text at original site
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引用元:
https://doi.org/10.1111/cbdd.13782

データ提供:米国国立医学図書館(NLM)

The Unexpected Link Between Proton Pump Inhibitors and Metal Ions

Proton pump inhibitors (PPIs) are widely used medications for treating conditions like heartburn and ulcers. While generally considered safe, there is growing concern about potential long-term effects, including an increased risk of certain diseases. This research investigates a previously overlooked phenomenon: the interaction between PPIs and transition metal ions, particularly iron, in the body. Using spectroscopic techniques, the researchers examined the interaction between PPIs and iron ions in a water-like environment. Their findings suggest that PPIs can form complexes with iron ions, raising concerns about potential disruptions in iron metabolism and the possible contribution to long-term health complications.

A New Perspective on PPI Side Effects

This study provides a novel perspective on PPI side effects, highlighting the potential role of metal ion interactions. The strong affinity between PPIs and iron ions, especially in the case of omeprazole, suggests that these interactions may play a role in the development of long-term complications associated with PPI use.

Navigating the Complexities of Proton Pump Inhibitors

The findings of this study raise important questions about the long-term safety of PPIs. While PPIs are effective medications for many people, it is crucial to be aware of the potential risks associated with their use, particularly with regard to iron metabolism. Further research is needed to fully understand the implications of these interactions and explore ways to minimize potential risks. It is also important to discuss your medical history and concerns with your healthcare provider to make informed decisions about your medication regimen.

Dr. Camel's Conclusion

This research is like a camel discovering a hidden spring in the desert, revealing a previously unknown aspect of PPI use. While PPIs can be a valuable tool for managing digestive issues, it is essential to be mindful of the potential hidden consequences. Further research is needed to understand the full impact of these interactions, ensuring that we can navigate the complex world of medication use with greater awareness and safety.

Date :
  1. Date Completed 2021-09-22
  2. Date Revised 2021-09-22
Further Info :

Pubmed ID

32854159

DOI: Digital Object Identifier

10.1111/cbdd.13782

SNS
PICO Info
in preparation
Languages

English

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