An Insight into Molecular Mechanisms and Novel Therapeutic Approaches in Epileptogenesis.

Author: RehniAshish Kumar, SinghShareen, SinghThakur Gurjeet

Paper Details 
Original Abstract of the Article :
Epilepsy is the second most common neurological disease with abnormal neural activity involving the activation of various intracellular signalling transduction mechanisms. The molecular and system biology mechanisms responsible for epileptogenesis are not well defined or understood. Neuroinflammatio...See full text at original site
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引用元:
https://doi.org/10.2174/1871527319666200910153827

データ提供:米国国立医学図書館(NLM)

Unveiling the Mysteries of Epileptogenesis: A Quest for New Therapies

This study delves into the intricate world of epileptogenesis, the process by which epilepsy develops. Epilepsy, a common neurological disorder, is characterized by abnormal neural activity involving the activation of various intracellular signaling pathways. The study explores the molecular and systemic biology mechanisms that contribute to epileptogenesis, focusing on neuroinflammation, neurodegeneration, and epigenetic modifications.

Epileptogenesis: A Complex Interplay of Molecular Events

The study highlights the complex interplay of molecular events that lead to epileptogenesis. Excessive neuronal activity triggers neurochemical changes, leading to excitotoxicity, inflammation, and ultimately neurodegeneration. The researchers also discuss the role of epigenetic modifications in the development of epilepsy, suggesting that these changes can influence gene expression and contribute to the disease process.

New Horizons in Epilepsy Treatment: Exploring Novel Targets

The study discusses the development of novel pharmacological agents targeting specific molecular pathways involved in epileptogenesis. These agents aim to attenuate the deleterious consequences of excitotoxicity, neuroinflammation, and neurodegeneration. The research highlights the need for a deeper understanding of these pathways to develop more effective treatments for epilepsy.

Dr.Camel's Conclusion

Just as a camel navigates the vast and unforgiving desert, researchers are navigating the complex landscape of epileptogenesis. This study, a beacon of hope for those affected by epilepsy, highlights the importance of continued research and innovation in the quest for more effective treatments and a deeper understanding of this challenging neurological condition.

Date :
  1. Date Completed 2021-10-26
  2. Date Revised 2021-10-26
Further Info :

Pubmed ID

32914725

DOI: Digital Object Identifier

10.2174/1871527319666200910153827

Related Literature

SNS
PICO Info
in preparation
Languages

English

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