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The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?

Author: CoveñasRafael, MuñozMiguel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article reviews the antitumor actions of aprepitant, a neurokinin-1 receptor (NK-1R) antagonist currently used as an antiemetic. Studies have demonstrated aprepitant's potential as an antitumor agent, with multiple effects including antiproliferation, apoptosis, anti-angiogenesis, and antimetastasis. The authors propose exploring aprepitant's use in cancer patients to prevent recurrence and metastasis, and discuss its potential role in combination therapies.
Paper Details　
Original Abstract of the Article :
Neurokinin-1 receptor (NK-1R) antagonists exert antitumor action, are safe and do not cause serious side-effects. These antagonists (via the NK-1R) exert multiple actions against cancer: antiproliferative and anti-Warburg effects and apoptotic, anti-angiogenic and antimetastatic effects. These multi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564414/

データ提供：米国国立医学図書館（NLM）

Aprepitant: A Potential Weapon in the Fight Against Cancer

Neurokinin-1 receptor (NK-1R) antagonists have shown promise in fighting cancer. This study explores the potential of aprepitant, an NK-1R antagonist currently used as an antiemetic, as a novel antitumor agent. The study reviews evidence for aprepitant's multiple antitumor actions, including its ability to inhibit cancer cell growth, angiogenesis, and metastasis.

Aprepitant's Multifaceted Action: A Versatile Weapon

The research highlights the diverse antitumor effects of aprepitant, suggesting its potential for a broader therapeutic role in cancer treatment. It also discusses the possibility of using aprepitant to prevent cancer recurrence and metastasis after surgical procedures.

Aprepitant's Promise: A New Hope for Cancer Patients

This research sheds light on the potential of aprepitant as a repurposed drug for cancer treatment. Further investigation is needed to fully understand its efficacy and safety in clinical settings. This could lead to new treatment strategies for a wide range of cancers.

Dr. Camel's Conclusion

Imagine aprepitant as a skilled archer, aiming its arrows at cancer cells. Its multiple actions, like different types of arrows, effectively target the tumor's different weaknesses. This study suggests that aprepitant could become a powerful weapon in the fight against cancer.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-27
Further Info :

Pubmed ID

32962202

DOI: Digital Object Identifier

PMC7564414

Related Literature

Article Analysis
・Side Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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