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Effects of Oral Contraception and Lifestyle Modification on Incretins and TGF-ß Superfamily Hormones in PCOS.

Author: AllisonKelly C, CoutifarisChristos, DodsonWilliam C, DokrasAnuja, EstesStephanie J, GnatukCarol L, Kris-EthertonPenny M, KunselmanAllen R, LegroRichard S, SarwerDavid B, ShahAesha, SlussPatrick M, StetterChristy M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Oral contraceptive pills (OCPs) significantly suppressed levels of activin A, inhibin A, and anti-mullerian hormone (AMH) while increasing follistatin (FST) levels in women with polycystic ovary syndrome (PCOS). OCPs also decreased levels of IGF-1, IGFBP-2, glucagon, and GLP-2. Lifestyle modifications did not significantly affect hormone levels.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To examine the effects of common treatments for polycystic ovary syndrome (PCOS) on a panel of hormones (reproductive/metabolic). DESIGN: Secondary analysis of blood from a randomized controlled trial of three 16-week preconception interventions designed to improve PCOS-related abnormali...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765645/

データ提供：米国国立医学図書館（NLM）

The Hormonal Landscape of Polycystic Ovary Syndrome Treatment

Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects millions of women worldwide. It can lead to irregular periods, acne, excess hair growth, and difficulty getting pregnant. This research investigates the effects of two common treatments for PCOS, oral contraceptive pills (OCPs) and intensive lifestyle modification, on a panel of hormones related to reproduction and metabolism.

Hormonal Changes in Response to PCOS Treatment

This study examined the effects of OCPs and lifestyle modification on a range of hormones in women with PCOS. The researchers found that OCPs had a significant impact on several hormones, including activin A, inhibin A, anti-mullerian hormone, and oxyntomodulin. Lifestyle modification, on the other hand, had a less pronounced effect on these hormones. This research provides valuable insights into the hormonal changes that occur in response to different treatment approaches for PCOS.

Navigating the Hormonal Desert of PCOS

This research helps us understand the complex hormonal landscape of PCOS and how different treatment options can impact these hormones. Just as a camel adapts to the fluctuating temperatures and water availability of the desert, women with PCOS need to understand the nuances of their condition and the potential impact of different treatments. This study provides valuable information for both patients and healthcare professionals as they navigate the complexities of PCOS management.

Dr.Camel's Conclusion

This research provides a map of the hormonal desert of PCOS, highlighting the impact of different treatment approaches on the hormonal landscape. It emphasizes the need for a personalized approach, considering the individual needs of each patient and carefully choosing the best treatment path to navigate this complex condition.
Date :
  1. Date Completed 2021-09-03
  2. Date Revised 2021-12-23
Further Info :

Pubmed ID

32968804

DOI: Digital Object Identifier

PMC7765645

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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