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Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein.

Author: AlvarezRaymond, BarriaMaria Ines, CalvoMario, ChahínCarolina, FerreiraLeonila, Fuentes-VillalobosFrancisco, GarridoJose L, Nova-LampertiEstefania, RiosecoMaría Luisa, RiquelmeRaúl, SaavedraFarides

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the role of CD4<sup>+</sup> T regulatory cells (Tregs) in the pathogenesis of hantavirus cardiopulmonary syndrome (HCPS) caused by Andes orthohantavirus (ANDV). The study found that memory CD4<sup>+</sup> Tregs from HCPS survivors exhibit a specific phenotype, with higher frequencies of PD-1 and lower frequencies of Th1-like memory CD4<sup>+</sup> Tregs compared to healthy donors. The authors suggest that ANDV glycoprotein (GP) may specifically modulate CXCR3 and CCR4 expression in CD4<sup>+</sup> Tregs, further contributing to the understanding of the immune response to ANDV infection.
Paper Details　
Original Abstract of the Article :
Hantavirus cardiopulmonary syndrome (HCPS) caused by Andes orthohantavirus (ANDV) in South America is a public health threat due to the significant rate of mortality and the lack of a specific treatment. Interestingly, the virus does not produce cytopathic effect, thereby the strong antiviral immune...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477076/

データ提供：米国国立医学図書館（NLM）

Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein

The field of [immunology] is constantly seeking to unravel the complex interplay between [viruses] and the [immune system]. This study investigates the role of [CD4+ T regulatory cells (Tregs)] in [Andes hantavirus (ANDV)] infection and explores the impact of [ANDV glycoprotein] on [Treg phenotype]. The researchers used a [cohort study] design, analyzing [blood samples] from [patients] who had survived [ANDV infection].

Andes Hantavirus and the Immune Response: A Complex Dance

The study found that [Tregs] in [ANDV survivors] exhibited a distinct phenotype, with increased expression of [PD-1] compared to [healthy donors]. Additionally, the study observed a decrease in [Th1-like Tregs] in [ANDV survivors]. These findings suggest that [ANDV] may induce specific changes in [Treg phenotype], potentially affecting the balance of [immune responses] during infection.

Potential Implications for Andes Hantavirus Infection and Treatment

The study's findings highlight the complex interplay between [ANDV] and the [immune system], suggesting a potential role for [Tregs] in controlling [immune responses] and potentially mitigating the severity of [ANDV infection]. This research could inform future strategies for developing [immunotherapies] to combat [ANDV infection] and related complications.

Dr.Camel's Conclusion

The research on [ANDV] and [Tregs] is like exploring a vast desert, where the immune system navigates a complex landscape of [viral threats]. This study helps us understand how [ANDV] might influence the immune system's response and offers promising insights for future research and treatment strategies.

Date :
  1. Date Completed 2021-06-17
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

32984065

DOI: Digital Object Identifier

PMC7477076

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PICO Info
in preparation
Languages

English

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