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Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.

Author: Haass-KofflerCarolina L, KennaGeorge A, LeeMary R, LeggioLorenzo, LiXiaobai, LongVictoria M, PiacentinoDaria, SwiftRobert M

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

A comparison study was conducted between nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies and treatment seekers with AD from the multisite COMBINE study. The study found that nontreatment seekers were more ethnically diverse, less educated, single, and working part-time or unemployed. They also had a significantly earlier age of onset and longer duration of AD. The study suggests that these differences should be considered in efforts to recruit participants for clinical research aimed at developing novel treatments for alcohol use disorder (AUD).
Paper Details　
Original Abstract of the Article :
BACKGROUND: One of the challenges in early-stage clinical research aimed at developing novel treatments for alcohol use disorder (AUD) is that the enrolled participants are heavy drinkers, but do not seek treatment for AUD. AIMS: To compare nontreatment seekers with alcohol dependence (AD) from 4 h...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32997422

データ提供：米国国立医学図書館（NLM）

Understanding Alcohol Use Disorder: Delving into the Differences Between Treatment Seekers and Non-Treatment Seekers

This study explores the differences in sociodemographic and alcohol-related clinical characteristics between treatment seekers and non-treatment seekers with alcohol dependence (AD), analyzing their role in predicting outcomes in the COMBINE Study. It's like studying two distinct camel caravans navigating the same desert landscape, uncovering the factors that influence their journeys and destinations.

Distinct Journeys: Uncovering the Differences Between Treatment Seekers and Non-Seekers

The study reveals significant differences between treatment seekers and non-treatment seekers with AD, including sociodemographic factors such as ethnicity, education level, and employment status, as well as alcohol-related clinical variables such as severity of alcohol dependence, age of onset, and duration of AD. It's like observing two caravans setting out on different paths, each shaped by unique circumstances and characteristics.

Predicting Outcomes: Identifying Key Factors for Success

The study found that specific characteristics, such as the number of heavy drinking days in the 30 days prior to baseline, could predict outcomes in the COMBINE Study, including time to relapse, percent days abstinent, and good clinical outcome. This finding highlights the importance of considering these factors when developing and implementing treatment strategies for alcohol use disorder. It's like understanding the terrain that each caravan faces, identifying the challenges and opportunities that lie ahead.

Dr.Camel's Conclusion

This study provides valuable insights into the diverse characteristics of individuals with alcohol dependence, highlighting the need for tailored treatment approaches based on individual needs and risk factors. It's like recognizing the unique features of different desert landscapes, ensuring that each caravan is equipped with the tools and strategies necessary to navigate its specific terrain.
Date :
  1. Date Completed 2021-09-29
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

32997422

DOI: Digital Object Identifier

NIHMS1629487

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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