Effective treatment of alcohol use disorder (aud): A Synthesis of Findings from 51 Studies

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Original Abstract of the Article

Major Research Findings

Alcohol use disorder (AUD) is a significant public health issue worldwide, imposing a substantial burden on individual health and socioeconomic well-being. 20 Historically, complete abstinence from alcohol has been the target outcome for AUD treatment. However, recent research indicates that reducing alcohol consumption, as measured by the World Health Organization (WHO) risk drinking levels, is associated with meaningful improvements in functioning, physical health, and quality of life after AUD treatment. 38

Pharmacotherapeutic agents for AUD have shown effectiveness in reducing heavy drinking days among individuals with AUD, but they are underutilized in clinical practice. 33 This could be attributed to barriers that might prevent patients from accessing medication-assisted treatment (MAT) for AUD in outpatient or residential settings. 33

Emerging complementary interventions for AUD include transcranial direct current stimulation (tDCS) and cognitive training. 35 Combining tDCS with alcohol cue inhibitory control training has shown potential in reducing the risk of early alcohol relapse. 35

The concept of controlled drinking, a non-abstinent approach, is being explored as an alternative to abstinence-based strategies in AUD treatment. 26 However, further research is needed to assess the efficacy of controlled drinking approaches compared to abstinence-based strategies. 26

Pharmacotherapy for AUD necessitates a more personalized approach, considering individual symptoms and conditions. 19

Exercise is emerging as a promising treatment option for AUD. 39 However, studies focusing on non-treatment-seeking individuals with AUD are lacking. 39

Internet-based interventions have demonstrated potential for effectiveness in AUD treatment and could facilitate access for individuals who might not seek or receive traditional treatment. 23

Cognitive behavioral therapy (CBT) is a valuable approach in AUD treatment, addressing factors such as anxiety and stress related to alcohol use, ultimately contributing to alcohol reduction. 50

Treatment Summary

A range of approaches are utilized in AUD treatment, including pharmacotherapy, cognitive behavioral therapy, exercise, and internet-based interventions. 33 19 39 23 50

Benefits and Risks

Benefit Summary

AUD treatment can lead to improved functioning, physical health, and quality of life, while also reducing the risk of relapse. 38 35

Risk Summary

Treatment for AUD may involve side effects associated with pharmacotherapy and potential challenges for patients engaging in CBT or exercise therapy. 33 19 39

Comparison Across Studies

Commonalities Among Studies

Numerous studies suggest that AUD treatment offers significant benefits to individuals and society. 38 20 33 35 26 19 39 23 50

Differences Among Studies

Variations exist between studies in terms of treatment methods, treatment goals, and the specific patient populations targeted. 38 20 33 35 26 19 39 23 50

Consistency and Contradictions in Findings

Research findings on the effectiveness of AUD treatment exhibit both consistency and contradictions. 38 20 33 35 26 19 39 23 50

Important Considerations for Real-World Application

AUD treatment requires individualized treatment plans tailored to each patient's unique needs. 38 20 33 35 26 19 39 23 50 It is crucial to consult with a physician or healthcare professional before starting any treatment. 38 20 33 35 26 19 39 23 50

Limitations of Current Research

Research on AUD treatment is still ongoing and requires further investigation. 38 20 33 35 26 19 39 23 50 Additional studies are necessary. 38 20 33 35 26 19 39 23 50

Future Research Directions

To gain a more comprehensive understanding of the effectiveness of AUD treatment, larger-scale studies and long-term follow-up investigations are needed. 38 20 33 35 26 19 39 23 50 Research comparing different treatment modalities and developing tailored treatments for individual patient characteristics is crucial. 38 20 33 35 26 19 39 23 50

Conclusion

AUD is a serious condition that can have a profound impact on many lives. 38 20 33 35 26 19 39 23 50 However, with proper treatment, individuals can improve their symptoms and lead healthier lives. 38 20 33 35 26 19 39 23 50 If you are struggling with AUD, it's recommended that you consult with a physician or healthcare professional. 38 20 33 35 26 19 39 23 50

Treatment List

Pharmacotherapy, Cognitive Behavioral Therapy, Exercise, Internet-based Interventions. 33 19 39 23 50

Keywords
Benefit Keywords
Reduced alcohol use
Reduced anxiety
1
Improved partner relationships
Reduced substance use
2
Improved alcohol-related problems
3
AUD treatment
4
Improved PTSD symptoms
Improved drinking outcomes
5
Alcohol use disorder treatment
6
Depression symptom reduction
Sleep quality improvement
8
Reduced drinking
11
Improve mental health
Reduce drinking
13
AUD treatment
14
Lapse time increase
Relapse time increase
15
Exposure therapy
PTSD and AUD treatment
16
SUD treatment
17
AUD treatment
18
Reduced heavy drinking
Total abstinence
19
AUD recovery
20
Well tolerated
21
AUD treatment
23
Reduced alcohol use
25
AUD treatment
26
AUD treatment
27
Improved mood
Reduced alcohol craving
28
Treatment for AUD
29
Cognitive training for AUD
30
Reduced alcohol craving
31
Personalized pharmacotherapy
Reduced drinking
32
AUD treatment
33
Treatment for co-occurring AUDs and depressive disorders
34
Increased abstinence rate
35
SAD and AUD treatment
36
AUD treatment
MAT
37
AUD treatment
38
AUD treatment
Exercise
39
AUD treatment
40
AUD treatment
41
ADG and CADG for severe AUD
42
AUD treatment
PTSD treatment
44
Alcohol use disorder treatment
Smoking cessation
45
AUD treatment
46
Exercise for AUD
47
Improved sleep
Reduced alcohol use
48
Alcohol use reduction
Treatment seeking
49
Alcohol reduction
Increased AUD treatment
50
Improved alcohol outcomes
Improved quality of life
Reduced substance use
51
Risk Keywords
Relapse
7
Alcohol relapse risk
8
Increased depressive symptoms
Worse functioning
9
Alcohol Use Disorder
10
Poor adherence
Tolerability
11
Drug misuse
Opioid misuse
12
ALD
Anxiety
Craving
15
Dizziness
19
Alcohol use disorder
22
Nontreatment seekers differ
24
None reported
25
Compounding disorders
43
Suboptimal adherence
47
None reported
48
Literature analysis of 51 papers
Positive Content
43
Neutral Content
2
Negative Content
6
Article Type
39
9
10
5
51
1.

Hybrid cognitive behavioral therapy versus relaxation training for co-occurring anxiety and alcohol disorder: a randomized clinical trial.

Author: KushnerMatt G, MaurerEric W, ThurasPaul, DonahueChris, FryeBrenda, MenaryKyle R, HobbsJennifer, HaenyAngela M, Van DemarkJoani

Reduced alcohol use
Reduced anxiety

This study investigated the challenges of treating alcohol use disorder (AUD) in patients with co-occurring anxiety disorders. While adding anxiety treatment to AUD treatment didn't significantly improve alcohol outcomes, a cognitive behavioral therapy (CBT) program designed to address both anxiety and alcohol use showed promise in improving outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

A randomized clinical trial of behavioral couples therapy versus individually based treatment for women with alcohol dependence.

Author: SchummJeremiah A, O'FarrellTimothy J, KahlerChristopher W, MurphyMarie M, MuchowskiPatrice

Improved partner relationships
Reduced substance use

A randomized controlled trial compared behavioral couples therapy (BCT) with individually based therapy (IBT) for women with alcohol use disorder (AUD). The study found that BCT was more efficacious than IBT in reducing substance use and substance-related problems and improving partner relationships.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

4.

Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels.

Author: WitkiewitzKatie, HallgrenKevin A, KranzlerHenry R, MannKarl F, HasinDeborah S, FalkDaniel E, LittenRaye Z, O'MalleyStephanie S, AntonRaymond F

AUD treatment

Alcohol use disorder (AUD) is a major public health problem with significant costs. While complete abstinence is often the goal of treatment, many people may prefer to reduce their drinking. This research suggests that using a measure of reduced alcohol consumption, specifically a decrease in the World Health Organization (WHO) risk levels of drinking, could be a useful way to evaluate the effectiveness of alcohol treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

5.

Posttraumatic Stress Disorder and Alcohol Use Disorder: A Critical Review of Pharmacologic Treatments.

Author: PetrakisIsmene L, SimpsonTracy L

Improved PTSD symptoms
Improved drinking outcomes

This review examined the effectiveness of pharmacotherapy treatments for alcohol use disorder (AUD) in patients with co-occurring posttraumatic stress disorder (PTSD), highlighting the need for further research to identify effective medications for this complex comorbidity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

6.

Randomized clinical trial of matching client alcohol use disorder severity and level of cognitive functioning to treatment setting: A partial replication and extension.

Author: RychtarikRobert G, McGillicuddyNeil B, PapandonatosGeorge D, WhitneyRobert B, ConnorsGerard J

Alcohol use disorder treatment

This study investigated the effectiveness of inpatient versus outpatient care for individuals with alcohol use disorder (AUD), considering factors like problem severity, cognitive functioning, and treatment expectancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Dimensional personality traits and alcohol treatment outcome: a systematic review and meta-analysis.

Author: FouldsJames, Newton-HowesGiles, GuyNicola H, BodenJoseph M, MulderRoger T

Relapse

This systematic review and meta-analysis found that patients with an alcohol use disorder who relapse during follow-up have higher novelty-seeking, lower persistence, lower reward dependence and lower cooperativeness than those who do not relapse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis.

Author: MillerMary Beth, DonahueMarissa L, CareyKate B, Scott-SheldonLori A J

Depression symptom reduction
Sleep quality improvement
Alcohol relapse risk

Insomnia interventions improve sleep quality and reduce symptoms of depression among individuals with comorbid AUD. Additional research is needed to determine the efficacy of insomnia treatment in improving rates of alcohol relapse within this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Adverse impact of marijuana use on clinical outcomes among psychiatry patients with depression and alcohol use disorder.

Author: BahorikAmber L, CampbellCynthia I, SterlingStacy A, LeibowitzAmy, TravisAdam, WeisnerConstance M, SatreDerek D

Increased depressive symptoms
Worse functioning

This study examined the association between marijuana use and clinical outcomes in patients with depression and alcohol use disorder (AUD), finding that marijuana use was associated with greater depressive symptoms and worse functioning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

10.

Duration of therapy - Does it matter?: A systematic review and meta-regression of the duration of psychosocial treatments for alcohol use disorder.

Author: Kramer SchmidtLotte, BojesenAnders Bo, NielsenAnette Søgaard, AndersenKjeld

Alcohol Use Disorder

This systematic review and meta-regression assessed the efficacy of psychosocial treatment in alcohol outpatient treatment centers. No associations were found between long-term alcohol use outcomes and planned or actual attended duration of psychosocial treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

A Randomized, Placebo-controlled, Clinical Trial of Prazosin for the Treatment of Alcohol Use Disorder.

Author: WilcoxClaire E, ToniganJ Scott, BogenschutzMichael P, CliffordJoshua, BigelowRose, SimpsonTracy

Reduced drinking
Poor adherence
Tolerability

Prazosin did not significantly affect rate of reduction in alcohol use in all participants, but did significantly increase the rate of reduction in drinks per week in an optimal treatment exposure subgroup.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

12.

Opioid Misuse as a Predictor of Alcohol Treatment Outcomes in the COMBINE Study: Mediation by Medication Adherence.

Author: WitkiewitzKatie, VotawVictoria R, VowlesKevin E, KranzlerHenry R

Drug misuse
Opioid misuse

Opioid misuse and other drug use were associated with poorer AUD treatment outcomes. Opioid misuse significantly predicted the time to first heavy drinking day and a higher probability of being in a heavier and more frequent drinking profile at the end of treatment and at 1 year following treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

13.

Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.

Author: WitkiewitzKatie, KranzlerHenry R, HallgrenKevin A, O'MalleyStephanie S, FalkDaniel E, LittenRaye Z, HasinDeborah S, MannKarl F, AntonRaymond F

Improve mental health
Reduce drinking

This study investigates the association between reductions in World Health Organization (WHO) drinking risk levels and improvements in physical health and quality of life in individuals with alcohol dependence, suggesting these reductions as alternative endpoints in clinical trials, reflecting reduced drinking and associated benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

14.

Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials: A Secondary Analysis of 3 Randomized Clinical Trials.

Author: FalkDaniel E, O'MalleyStephanie S, WitkiewitzKatie, AntonRaymond F, LittenRaye Z, SlaterMegan, KranzlerHenry R, MannKarl F, HasinDeborah S, JohnsonBankole, MeulienDidier, RyanMegan, FertigJoanne,

AUD treatment

The US Food and Drug Administration considers complete abstinence from alcohol and no heavy drinking days as successful outcomes for alcohol use disorder (AUD) medications. However, many people struggle to achieve these goals, which discourages them from seeking treatment and has slowed the development of new medications that help with alcohol use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

15.

Clinical Predictors of Response to Baclofen in the Treatment of Alcohol use Disorder: Results from the BacALD Trial.

Author: RomboutsSusan A, BaillieAndrew, HaberPaul S, MorleyKirsten C

Lapse time increase
Relapse time increase
ALD
Anxiety
Craving

Baclofen, relative to placebo, was more effective in patients with alcohol use disorder (AUD) who had higher alcohol consumption at baseline. There were no predictive effects of other baseline characteristics on time to lapse or time to relapse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial.

Author: NormanSonya B, TrimRyan, HallerMoira, DavisBrittany C, MyersUrsula S, ColvonenPeter J, BlanesErika, LyonsRobert, SiegelEmma Y, AngkawAbigail C, NormanGregory J, MayesTina

Exposure therapy
PTSD and AUD treatment

This study explores the effectiveness and safety of exposure therapy for people who have both PTSD and alcohol use disorder (AUD). Since these conditions frequently occur together, it's important to determine if exposure therapy, a common PTSD treatment, is an appropriate and helpful approach for this specific group of patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

17.

Change in psychosocial factors connected to coping after inpatient treatment for substance use disorder: a systematic review.

Author: JohannessenDagny Adriaenssen, NordfjærnTrond, GeirdalAmy Østertun

SUD treatment

Substance use disorders (SUDs) are a significant public health problem. This review examines how psychological factors related to coping skills and personal resources change after inpatient treatment for SUDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Treating Alcohol Use Disorder in U.S. Veterans: The Role of Traumatic Brain Injury.

Author: JorgeRicardo E, LiRuosha, LiuXiangyu, McGavinJill K, ShorterDaryl I, AcionLaura, ArndtStephan

AUD treatment

Valproate did not significantly reduce relapse to heavy drinking in veterans with alcohol use disorder (AUD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial.

Author: AntonRaymond F, LathamPatricia, VoroninKonstantin, BookSarah, HoffmanMichaela, PrisciandaroJames, BristolEmily

Reduced heavy drinking
Total abstinence
Dizziness

Gabapentin might be most efficacious in people with alcohol use disorder and a history of alcohol withdrawal symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

20.

Alcoholics Anonymous and other 12-step programs for alcohol use disorder.

Author: KellyJohn F, HumphreysKeith, FerriMarica

AUD recovery

Alcohol use disorder (AUD) causes significant problems, including premature death, injuries, crime, and increased healthcare costs. Alcoholics Anonymous (AA) has been helping people recover from AUD for over 80 years, but only recently has its effectiveness been rigorously studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Olanzapine Plus Samidorphan (ALKS 3831) in Schizophrenia and Comorbid Alcohol Use Disorder: A Phase 2, Randomized Clinical Trial.

Author: BrunetteMary F, CorrellChristoph U, O'MalleyStephanie S, McDonnellDavid, DiPetrilloLauren, JiangYing, SimmonsAdam, SilvermanBernard L, CitromeLeslie, GreenAlan I

Well tolerated

This study found that olanzapine combined with samidorphan was not superior to olanzapine alone in treating alcohol use disorder (AUD) in patients with schizophrenia.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

The prevalence and factors associated with alcohol use disorder among people living with HIV/AIDS in Africa: a systematic review and meta-analysis.

Author: NechoMogesie, BeleteAsmare, GetachewYibeltal

Alcohol use disorder

The average 1-year prevalence of alcohol use disorder (AUD) in HIV/AIDS patients was 22.03%. Factors associated with AUD included being male, cigarette smoking, and khat chewing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Internet-based therapy versus face-to-face therapy for alcohol use disorder, a randomized controlled non-inferiority trial.

Author: JohanssonMagnus, SinadinovicKristina, GajeckiMikael, LindnerPhilip, BermanAnne H, HermanssonUlric, AndréassonSven

AUD treatment

This study compared the effectiveness of online treatment versus traditional in-person treatment for people with alcohol use disorder (AUD). While many people with AUD don't seek help, online interventions have shown promise in reducing alcohol use, potentially overcoming barriers to accessing care. The study aims to determine if online treatment is as effective as in-person treatment for AUD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.

Author: Haass-KofflerCarolina L, PiacentinoDaria, LiXiaobai, LongVictoria M, LeeMary R, SwiftRobert M, KennaGeorge A, LeggioLorenzo

Nontreatment seekers differ

A comparison study was conducted between nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies and treatment seekers with AD from the multisite COMBINE study. The study found that nontreatment seekers were more ethnically diverse, less educated, single, and working part-time or unemployed. They also had a significantly earlier age of onset and longer duration of AD. The study suggests that these differences should be considered in efforts to recruit participants for clinical research aimed at developing novel treatments for alcohol use disorder (AUD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

25.

Impact of comorbid mental disorders on outcomes of brief outpatient treatment for DSM-5 alcohol use disorder in older adults.

Author: BehrendtSilke, KuerbisAlexis, BilbergRandi, Braun-MichlBarbara, MejldalAnna, BühringerGerhard, BogenschutzMichael, AndersenKjeld, NielsenAnette Søgaard

Reduced alcohol use
None reported

Comorbid mental disorders have modest effects on short-term outpatient treatment outcomes for alcohol use disorder (AUD) in older adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Controlled drinking-non-abstinent versus abstinent treatment goals in alcohol use disorder: a systematic review, meta-analysis and meta-regression.

Author: HensslerJonathan, MüllerMartin, CarreiraHelena, BschorTom, HeinzAndreas, BaethgeChristopher

AUD treatment

Many people with alcohol use disorder (AUD) don't get treatment. A new approach is to explore controlled drinking strategies, rather than complete abstinence. This review will compare the effectiveness of treatments that don't require complete abstinence to those that do.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Moderation of Prazosin's Efficacy by Alcohol Withdrawal Symptoms.

Author: SinhaRajita, WemmStephanie, FogelmanNia, MilivojevicVerica, MorganPeter M, AngaritaGustavo A, HermesGretchen, FoxHelen C

AUD treatment

Alcohol use disorder (AUD) is a serious problem. Heavy drinking can lead to withdrawal symptoms like cravings, mood swings, anxiety, and sleep problems, making treatment more difficult. This study will examine whether the severity of these withdrawal symptoms affects how well prazosin, a medication, works to reduce alcohol use and other problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Effects of acute exercise on craving, mood and anxiety in non-treatment seeking adults with alcohol use disorder: An exploratory study.

Author: HallgrenMats, VancampfortDavy, HoangMinh Tuan, AnderssonVictoria, EkblomÖrjan, AndreassonSven, HerringMatthew P

Improved mood
Reduced alcohol craving

A short bout of aerobic exercise reduced alcohol craving and improved mood states in adults with alcohol use disorder (AUD). The positive effects of exercise were maintained 30 minutes post-exercise.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Stability of Posttreatment Reductions in World Health Organization (WHO) Drinking Risk Levels and Posttreatment Functioning in Older Adults with DSM-5 Alcohol Use Disorder: Secondary Data Analysis of the Elderly Study.

Author: MejldalAnna, AndersenKjeld, BehrendtSilke, BilbergRandi, BogenschutzMichael, Braun-MichlBarbara, BühringerGerhard, Søgaard NielsenAnette

Treatment for AUD

This study investigates the long-term stability of reductions in World Health Organization (WHO) drinking risk levels following treatment for alcohol use disorder (AUD) and its association with functional improvements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Virtual Reality Cognitive Training Among Individuals With Alcohol Use Disorder Undergoing Residential Treatment: Pilot Randomized Controlled Trial.

Author: GamitoPedro, OliveiraJorge, MatiasMarcelo, CunhaElsa, BritoRodrigo, LopesPaulo Ferreira, DeusAlberto

Cognitive training for AUD

This study explores the use of digital interactive-based interventions for addressing cognitive and executive deficits in alcohol use disorder (AUD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Changes in craving following acute aerobic exercise in adults with alcohol use disorder.

Author: HallgrenMats, HerringMatthew P, VancampfortDavy, HoangMinh Tuan, AnderssonVictoria, AndreassonSven, AbrantesAna M

Reduced alcohol craving

This exploratory study examined the effects of acute exercise on alcohol craving in adults with alcohol use disorder. Most participants experienced a reduction in craving after exercise, with those with higher pre-exercise cravings and lower cardiorespiratory fitness being most likely to benefit.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Alcohol use disorder severity moderates clinical response to varenicline.

Author: DonatoSuzanna, GreenReJoyce, RayLara A

Personalized pharmacotherapy
Reduced drinking

This study aims to identify specific characteristics of people with alcohol use disorder (AUD) that predict how well they respond to varenicline, a medication used to reduce alcohol consumption. The study looks at different aspects of AUD severity to better understand which patients are most likely to benefit from varenicline treatment.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

First-line Medications for the Outpatient Treatment of Alcohol Use Disorder: A Systematic Review of Perceived Barriers.

Author: GregoryCaroline, ChornyYelena, McLeodShelley L, MohindraRohit

AUD treatment

Alcohol use disorder (AUD) is a serious problem that has major health and economic consequences. While there are medications that can help reduce heavy drinking, they are not used often enough. This review will look at the reasons why people with AUD may not get medication for their addiction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Clinical interventions for adults with comorbid alcohol use and depressive disorders: A systematic review and network meta-analysis.

Author: GrantSean, AzharGulrez, HanEugeniu, BoothMarika, MotalaAneesa, LarkinJody, HempelSusanne

Treatment for co-occurring AUDs and depressive disorders

There's still a lack of clarity on how effective treatments are for people with both alcohol use disorder (AUD) and depression. This study aimed to compare the effectiveness of different therapeutic approaches for improving symptoms in adults with these co-occurring conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Transcranial direct current stimulation combined with alcohol cue inhibitory control training reduces the risk of early alcohol relapse: A randomized placebo-controlled clinical trial.

Author: DubusonMacha, KornreichCharles, VanderhasseltMarie-Anne, BaekenChris, WyckmansFlorent, DoussetClémence, HanakCatherine, VeeserJohannes, CampanellaSalvatore, ChatardArmand, JaafariNemat, NoëlXavier

Increased abstinence rate

This randomized clinical trial found that transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) led to a significantly higher abstinence rate in alcohol use disorder (AUD) patients during the weeks following rehabilitation. Combining tDCS with alcohol cue inhibitory control training may provide better clinical outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Development and Initial Pilot Testing of a fully integrated treatment for comorbid social anxiety disorder and alcohol use disorder in a community-based SUD clinic setting.

Author: Wolitzky-TaylorKate, SewartAmy, KarnoMitchell, RiesRichard, StimsonJanice

SAD and AUD treatment

This study suggests that incorporating treatment for social anxiety disorder (SAD) into programs for alcohol use disorder (AUD) could improve treatment outcomes for people with both conditions. Since SAD and AUD often occur together, combining treatments for both disorders could enhance engagement and lead to better results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Pharmacological interventions for alcohol misuse in correctional settings: A systematic review.

Author: Slavin-StewartClaire, MinhasMeenu, TurnaJasmine, BraschJennifer, OlagunjuAndrew Toyin, ChaimowitzGary, MacKillopJames

AUD treatment
MAT

Alcohol use disorder (AUD) is much more common in the criminal justice system than in the general population. It's also a major factor that increases the chance of reoffending. Medication-assisted treatment (MAT) is a proven way to reduce alcohol use, but we need to see how well it works for people in prison. This review will examine research on MAT for AUD in correctional settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

The Relationship Between Reductions in WHO Risk Drinking Levels During Treatment and Subsequent Healthcare Costs for the ACTIVE Workgroup.

Author: AldridgeArnie P, ZarkinGary A, DowdWilliam N, WitkiewitzKatie, HasinDeborah S, O'MalleyStephanie S, IsenbergKeith, AntonRaymond F

AUD treatment

While complete abstinence has been the goal of alcohol use disorder (AUD) treatment, studies show that even reducing alcohol intake to safer levels can significantly improve people's lives, including their health, well-being, and ability to function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

39.

Effects of exercise in non-treatment seeking adults with alcohol use disorder: A three-armed randomized controlled trial (FitForChange).

Author: GunillasdotterVictoria, AndréassonSven, JirweMaria, EkblomÖrjan, HallgrenMats

AUD treatment
Exercise

This study examined the effects of exercise (aerobic and yoga) and standard support on alcohol consumption in people with alcohol use disorder (AUD) who are not actively seeking treatment. The researchers aimed to determine if exercise could be a helpful approach for those who are not engaging in traditional treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Alcohol-related consequences and the intention to seek care in treatment naïve women and men with severe alcohol use disorder.

Author: ConnerKenneth R, AbarBeau, AldalurAileen, ChiangAndrew, HutchisonMorica, MaistoStephen A, SteckerTracy

AUD treatment

This study will look at people with severe alcohol use disorder (AUD) who aren't currently in treatment to understand why they might be more likely to seek help. It will examine if the consequences of alcohol use, rather than how much they drink, are linked to their willingness to get treatment. The study will also look at whether these factors affect men and women differently.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

41.

Predictors of abstinence, no heavy drinking days, and a 2-level reduction in World Health Organization drinking levels during treatment for alcohol use disorder in the COMBINE study.

Author: WallachJoshua D, GueorguievaRalitza, PhanHuong, WitkiewitzKatie, WuRan, O'MalleyStephanie S

AUD treatment

This study aimed to identify factors that predict how well people with alcohol use disorder (AUD) respond to treatment, regardless of the specific medication they receive. The researchers used data from a large study called COMBINE to determine which characteristics are associated with successful outcomes, such as abstaining from alcohol, reducing heavy drinking days, or making significant reductions in alcohol consumption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

42.

Different Goals, Different Needs: The Effects of Telephone- and Text Message-Based Continuing Care for Patients with Different Drinking Goals After Residential Treatment for Alcohol Use Disorder.

Author: GraserYolanda, StutzSonja, RösnerSusanne, WopfnerAlexander, MoggiFranz, SoraviaLeila M

ADG and CADG for severe AUD

This study examined the effects of different drinking goals (abstinent versus conditional abstinence) on drinking outcomes in patients with severe alcohol use disorder (AUD) after residential treatment. The study also investigated the effectiveness of telephone-based and text message-based continuing care according to the individual drinking goal.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

43.

Alcohol use disorder with comorbid anxiety disorder: a case report and focused literature review.

Author: MocanuVictor, WoodEvan

Compounding disorders

Alcohol use disorder (AUD) and anxiety disorders (AnxD) often co-occur and complicate treatment. This review examines the challenges and approaches to managing concurrent AUD-AnxD.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

44.

Cognitive Processing Therapy or Relapse Prevention for comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A randomized clinical trial.

Author: SimpsonTracy L, KaysenDebra L, FlemingCharles B, RhewIsaac C, JaffeAnna E, DesaiSruti, HienDenise A, BerlinerLucy, DonovanDennis, ResickPatricia A

AUD treatment
PTSD treatment

A study of 101 patients with both PTSD and AUD found that treatments targeting either PTSD or AUD improved both PTSD symptoms and drinking outcomes. Cognitive Processing Therapy (CPT) was more effective than assessment-only (AO) in reducing PTSD symptoms, while both CPT and Relapse Prevention (RP) were more effective than AO in reducing heavy drinking days.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

45.

Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels.

Author: NietoSteven J, EndersCraig K, WitkiewitzKatie, O'MalleyStephanie S, RayLara A

Alcohol use disorder treatment
Smoking cessation

While complete abstinence is the main goal of alcohol use disorder (AUD) treatments, many people struggle to achieve this, potentially discouraging them from seeking help. This study tested the use of World Health Organization (WHO) risk drinking levels as a possible treatment outcome for AUD medication trials. The researchers also explored the effectiveness of combining varenicline (a medication for smoking cessation) and naltrexone (a medication for AUD) in a clinical trial, providing further evidence on the potential of this combination approach.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

46.

Trajectories of change in subclinical anxiety and alcohol use during alcohol treatment: A parallel process growth model.

Author: HurlockerMargo C, CarlonHannah, PearsonMatthew R, HijazDonia

AUD treatment

Anxiety plays a role in alcohol use disorder (AUD) and its treatment outcomes. This study will examine how anxiety symptoms change over time in people with AUD, both during and after treatment, to see how it's related to changes in alcohol use.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

47.

Sticking with it? Factors associated with exercise adherence in people with alcohol use disorder.

Author: WelfordPaul, GunillasdotterVictoria, AndreassonSven, HerringMatthew P, VancampfortDavy, HallgrenMats

Exercise for AUD
Suboptimal adherence

This secondary analysis of a randomized controlled trial examined factors associated with adherence to an exercise intervention for non-treatment seeking adults with alcohol use disorder (AUD). The study found that just under half (49%) of the participants completed 12 supervised exercise sessions. Moderate and severe AUD were significantly associated with non-adherence, as were higher body mass index and lower education levels.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Effect of Cognitive Behavioral Therapy for Insomnia on Alcohol Treatment Outcomes Among US Veterans: A Randomized Clinical Trial.

Author: MillerMary Beth, CarpenterRyan W, FreemanLindsey K, DunsigerShira, McGearyJohn E, BorsariBrian, McCraeChristina S, ArnedtJ Todd, KortePaul, MerrillJennifer E, CareyKate B, MetrikJane

Improved sleep
Reduced alcohol use
None reported

Cognitive behavioral therapy for insomnia (CBT-I) was more effective than sleep hygiene in reducing insomnia symptoms and alcohol-related problems in veterans early in their alcohol use disorder (AUD) treatment. CBT-I participants reported greater decreases in insomnia severity at posttreatment (group × time interaction: -3.70; 95% CI, -6.79 to -0.61) and follow-up (-3.34; 95% CI, -6.46 to -0.23) and greater improvements in sleep efficiency (posttreatment, 8.31; 95% CI, 1.35 to 15.26; follow-up, 18.03; 95% CI, 10.46 to 25.60). CBT-I should be considered a first-line treatment for insomnia in AUD regardless of abstinence.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

49.

Brief, cognitive-behavioral intervention to promote treatment seeking in adults with severe alcohol use disorder: A randomized controlled trial.

Author: ConnerKenneth R, MaistoStephen A, AbarBeau, SzafranskiSarah, ChiangAndrew, HutchisonMorica, AldalurAileen, SteckerTracy

Alcohol use reduction
Treatment seeking

This study aims to determine if a brief intervention can encourage people with severe alcohol use disorder (AUD) who haven't sought treatment to do so, and whether seeking treatment leads to reduced alcohol use.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

50.

Improving alcohol treatment engagement using integrated behavioral interventions in alcohol-associated liver disease: A randomized pilot trial.

Author: MellingerJessica L, MedleySarah, KidwellKelley M, AsefahHaila, WinderG Scott, FernandezAnne C, LokAnna S F, BlowFred

Alcohol reduction
Increased AUD treatment

A mobile health intervention designed to increase alcohol use disorder (AUD) treatment engagement was highly feasible, acceptable, and produced promising early outcomes, with improved AUD treatment engagement and alcohol reduction in alcohol-associated liver disease (ALD) patients.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

51.

Impact of Harm Reduction Treatment with or without Pharmacotherapy on Polysubstance Use among People Experiencing Homelessness and Alcohol Use Disorder.

Author: MostofiNicole, CollinsSusan E

Improved alcohol outcomes
Improved quality of life
Reduced substance use

This secondary study found that behavioral harm reduction treatment for alcohol use disorder (AUD), or HaRT-A, was effective in improving alcohol and other substance use outcomes for people experiencing homelessness and AUD.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

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