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IL-22-induced cell extrusion and IL-18-induced cell death prevent and cure rotavirus infection.
Author: ChassaingBenoit, Etienne-MesminLucie, GewirtzAndrew T, ShaoFeng, ShiXuyan, ShiZhenda, WangYanling, ZhangBenyue, ZhangZhan, ZouJun
Original Abstract of the Article :
Bacterial flagellin can elicit production of TLR5-mediated IL-22 and NLRC4-mediated IL-18 cytokines that act in concert to cure and prevent rotavirus (RV) infection. This study investigated the mechanism by which these cytokines act to impede RV. Although IL-18 and IL-22 induce each other's expressi...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://pubmed.ncbi.nlm.nih.gov/33008915
データ提供：米国国立医学図書館（NLM）
Rotavirus: A Desert Oasis of IL-22 and IL-18
Rotavirus (RV) infection is a leading cause of severe diarrhea in infants and young children. This study explores the role of IL-22 and IL-18, two cytokines involved in immune responses, in preventing and curing RV infection. The authors demonstrate that IL-22 and IL-18, induced by bacterial flagellin, act in concert to effectively combat RV infection. The research reveals distinct mechanisms of action for these cytokines, with IL-22 promoting cell extrusion and IL-18 inducing cell death of RV-infected intestinal epithelial cells (IEC). The study provides valuable insights into the potential of IL-22 and IL-18 as therapeutic targets for treating viral infections.
IL-22 and IL-18: A Powerful Duo Against Rotavirus
The study reveals a promising strategy for combating RV infection, highlighting the synergistic effects of IL-22 and IL-18. The research demonstrates that these cytokines, induced by bacterial flagellin, can effectively prevent and cure RV infection by promoting IEC extrusion and inducing cell death of infected cells. The findings suggest that targeting these cytokines could be a valuable approach for developing new therapies to treat viral infections.
Navigating the Desert of Viral Infections
The desert of viral infections can be a challenging landscape, particularly for young children who are vulnerable to severe complications. This study offers a glimmer of hope, highlighting the potential of IL-22 and IL-18 to combat viral infections. The research suggests that these cytokines could be a valuable target for developing new therapies to effectively prevent and treat viral infections, particularly those that target epithelial cells.
Dr.Camel's Conclusion
The desert of viral infections can be a formidable foe, but this study reveals a potential oasis of hope in the form of IL-22 and IL-18. These cytokines, induced by bacterial flagellin, demonstrate potent antiviral activity, offering a promising avenue for developing new therapies to combat viral infections, especially those that target epithelial cells.
Date :
- Date Completed 2021-09-20
- Date Revised 2023-12-13
Further Info :
Related Literature
English
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