Paper Details

  1. Home
  2. Paper Details

Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy.

Author: CasettariLuca, FigueiredoPatrícia, FontanaFlavia, HirvonenJouni, KostiainenMauri A, LeplandAnni, SantosHélder A, ScodellerPablo, ShahbaziMohammad-Ali, TeesaluTambet, TiboniMattia, TorrieriGiulia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lignin nanoparticles loaded with a TLR7/8 agonist (resiquimod) and targeted to M2-like macrophages were found to enhance the anti-cancer effect of vinblastine in a triple-negative breast cancer model. The targeted delivery of the TLR7/8 agonist reprogrammed the tumor microenvironment, increasing anti-tumor immune responses.
Paper Details　
Original Abstract of the Article :
Nanomedicines represent innovative and promising alternative technologies to improve the therapeutic effects of different drugs for cancer ablation. Targeting M2-like tumor-associated macrophages (TAMs) has emerged as a favorable therapeutic approach to fight against cancer through the modulation of...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.actbio.2020.09.038

データ提供：米国国立医学図書館（NLM）

Targeting Tumor-Associated Macrophages with Lignin Nanoparticles: A New Strategy

Cancer, like a relentless sandstorm, can be incredibly difficult to conquer. This study investigates a novel approach to fighting cancer by targeting tumor-associated macrophages (TAMs), cells that can promote tumor growth.

Lignin Nanoparticles Reprogram TAMs for Enhanced Chemotherapy

The researchers developed lignin nanoparticles loaded with resiquimod (R848), an immune-stimulating molecule, and targeted them to CD206-positive TAMs. This approach successfully reprogrammed TAMs from a pro-tumor phenotype to an anti-tumor phenotype, enhancing the effectiveness of chemotherapy in a triple-negative breast cancer model. This groundbreaking research offers a promising new strategy for combating cancer.

A New Oasis in the Desert of Cancer Research

This study represents a significant advancement in the fight against cancer. The development of targeted lignin nanoparticles that reprogram TAMs opens up new avenues for more effective cancer treatment. This approach offers hope for a brighter future in the battle against this formidable disease.

Dr.Camel's Conclusion

This research is like finding a hidden oasis in the desert of cancer research. The innovative approach of targeting TAMs with lignin nanoparticles, combined with chemotherapy, offers a promising new strategy for combating cancer. This groundbreaking work highlights the power of scientific exploration and the potential for finding innovative solutions to some of the world's most pressing health challenges.

Date :
  1. Date Completed 2021-10-22
  2. Date Revised 2021-10-22
Further Info :

Pubmed ID

33011297

DOI: Digital Object Identifier

10.1016/j.actbio.2020.09.038

Related Literature

Article Analysis
・Side Effects of vinblastine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.