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Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine.

Author: ChapmanR C, KimmeyM B, SaundersD R, SilversteinF E

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Cimetidine coadministered with aspirin reduced gastric mucosal injury. A 200-mg dose of cimetidine was effective in reducing mucosal injury compared to placebo (P<.001).
Paper Details　
Original Abstract of the Article :
We studied the influence of cimetidine on the gastroscopically visible effects of a single 1296-mg dose of aspirin. An initial dose-response study in 48 subjects showed that 200- and 400-mg doses of cimetidine conferred a sufficient reduction in gastric mucosal injury to warrant further study. A sec...See full text at original site
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引用元：
https://doi.org/10.1007/BF01296708

データ提供：米国国立医学図書館（NLM）

Cimetidine: A Shield Against Aspirin-Induced Gastric Injury

Aspirin, a common pain reliever, can sometimes cause damage to the stomach lining. This is like a harsh desert wind eroding a fragile oasis. This study explores the ability of cimetidine, a drug that reduces stomach acid, to protect against this damage. It's like building a protective wall around the oasis, shielding it from the harsh desert elements.

Cimetidine: A Protective Oasis for the Stomach

The study found that cimetidine, when taken with aspirin, significantly reduced the amount of gastric mucosal injury. It's like creating a refreshing spring within the desert, providing a soothing and protective environment for the delicate stomach lining. This finding suggests that cimetidine could potentially be used to prevent chronic aspirin-induced gastric injury.

Protecting Your Stomach: A Wise Decision

If you take aspirin regularly and are concerned about the potential for stomach damage, consult with your doctor about using cimetidine. It's like ensuring your oasis remains safe and healthy by taking precautions against the harsh desert environment. It's always best to talk to your doctor before making changes to your medication regimen.

Dr. Camel's Conclusion

Cimetidine provides a protective shield against aspirin-induced gastric injury, like a sturdy wall protecting a precious oasis. It's important to consult your doctor about the best course of action, ensuring a safe and healthy journey through the desert of medication.

Date :
  1. Date Completed 1987-09-10
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

3301232

DOI: Digital Object Identifier

10.1007/BF01296708

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・Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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