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Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment.
Author: AllonNahum, GabayMartin, GavishMoshe, KahanaMeygal, ObeidFadi, WeizmanAbraham, ZeinehNidal
Original Abstract of the Article :
Brain tumors are hard to treat with the currently available therapy. The major obstacle in the treatment of brain tumors is the lack of therapeutic strategies capable to penetrate the blood-brain barrier (BBB). The BBB is an endothelial interface that separates the brain from the circulatory blood s...See full text at original site
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引用元:
https://doi.org/10.1007/s10571-020-00969-1
データ提供:米国国立医学図書館(NLM)
Liposomal Carriers: A Caravan Crossing the Blood-Brain Barrier
[Brain tumors] are notoriously difficult to treat due to the [blood-brain barrier (BBB)], a protective shield that limits the passage of drugs into the brain. This research explores a novel [drug-delivery system] employing [liposomal carriers] conjugated to an [APP-derived peptide] that is purportedly recognized by BBB transporters. The authors designed this [targeted liposomal system] to deliver [anti-cancer compounds] directly to the brain, bypassing the BBB's formidable defenses. Their findings demonstrate the effectiveness of this system in both [in vitro] and [in vivo] models, suggesting a promising approach for [brain cancer treatment].
A New Route to Brain Cancer Treatment
The research's findings are encouraging, demonstrating that [targeted liposomal carriers] can successfully deliver [anti-cancer compounds] across the BBB. The authors' data highlight the potential of this approach to improve [therapeutic efficacy] in [glioblastoma], a particularly aggressive form of brain cancer. Further clinical trials are needed to confirm the safety and efficacy of this promising new treatment strategy.
Crossing the Sands of the Blood-Brain Barrier
This research offers a ray of hope in the vast desert of [brain cancer] research. The authors' innovative approach to drug delivery could revolutionize the way we treat these challenging tumors. By harnessing the power of [targeted liposomal carriers], we may finally be able to cross the formidable sand dunes of the BBB and deliver life-saving treatments to those in need.
Dr. Camel's Conclusion
This study provides a compelling demonstration of the potential for [targeted liposomal carriers] to overcome the challenges of the BBB and deliver effective treatments for [brain cancer]. It is a beacon of hope in the vast desert of brain tumor research.
Date :
- Date Completed 2021-12-03
- Date Revised 2021-12-22
Further Info :
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