Paper Details

  1. Home
  2. Paper Details

Treatment of refractory depression with combination reserpine and tricyclic antidepressant therapy.

Author: AmsterdamJ D, BerwishN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

High-dose reserpine was not found to be effective in treating nine patients with severe depression who had failed to respond to at least six previous drug treatments.
Paper Details　
Original Abstract of the Article :
Chronic reserpine use has been reported to precipitate severe depression in some individuals as a result of its amine-depleting action. However, early clinical studies demonstrated that acute administration of high doses of parenteral reserpine in combination with a tricyclic antidepressant could pr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/3305592

データ提供：米国国立医学図書館（NLM）

Treatment of Refractory Depression with Combination Reserpine and Tricyclic Antidepressant Therapy

Depression is a complex mental health condition that can be challenging to treat. This research investigates the potential benefits of combining reserpine, a medication that depletes certain brain chemicals, with tricyclic antidepressants in treating patients with refractory depression, a form of depression that doesn't respond to conventional treatments. The study aimed to evaluate the effectiveness and safety of this drug combination in patients who had not responded to previous treatments.

Reserpine and Tricyclic Antidepressants: Exploring New Treatment Strategies

The results of the study were mixed, with limited evidence to support the effectiveness of this drug combination in treating refractory depression. However, the study noted that one patient did show improvement with a second course of reserpine. The researchers also emphasized the importance of carefully monitoring patients for potential side effects when using this combination therapy. This study highlights the need for ongoing research to develop effective treatments for refractory depression.

Navigating the Complexities of Depression: Finding Hope in Treatment Research

This research underscores the complexity of mental health conditions and the ongoing search for effective treatments. While the combination of reserpine and tricyclic antidepressants didn't show significant effectiveness in this study, it's important to remember that research continues to explore new and promising therapeutic strategies for depression. Just as a camel perseveres through the challenging desert landscape, those facing depression need to maintain hope and seek professional help to find the right treatment approach.

Dr. Camel's Conclusion

This research explored the potential of combining reserpine and tricyclic antidepressants for refractory depression. While the results were limited, it highlights the need for continued research into novel treatments for this challenging condition. Finding the right treatment approach for depression requires patience, perseverance, and a collaborative effort between patients and healthcare providers.

Date :
  1. Date Completed 1987-10-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3305592

DOI: Digital Object Identifier

3305592

Related Literature

Article Analysis
・Effects of reserpine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.